The role of T-lymphocyte subsets and interleukin-5 blood levels among Indian subjects with autoimmune thyroid disease

Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.

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Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

Immunologic Research ◽

10.1007/s12026-014-8598-9 ◽

2014 ◽

Vol 60 (2-3) ◽

pp. 193-200 ◽

Cited By ~ 17

Author(s):

Ivica Lazúrová ◽

Ivana Jochmanová ◽

Karim Benhatchi ◽

Štefan Sotak

Keyword(s):

Rheumatoid Arthritis ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Autoimmune Thyroid

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Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of recepto amino acids ser25-glu30

Immuno-analyse & Biologie Spécialisée ◽

10.1016/s0923-2532(05)80538-1 ◽

1993 ◽

Vol 8 (5) ◽

pp. 327

Keyword(s):

Amino Acids ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Thyrotropin Receptor ◽

Autoimmune Thyroid

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Emerging Roles for Noncoding RNAs in Autoimmune Thyroid Disease

Endocrinology ◽

10.1210/endocr/bqaa053 ◽

2020 ◽

Vol 161 (8) ◽

Author(s):

Liang Yin ◽

Chong Zeng ◽

Jie Yao ◽

Jie Shen

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Noncoding Rnas ◽

Autoimmune Disorders ◽

Present Knowledge ◽

Long Noncoding Rnas ◽

Circular Rnas ◽

Autoimmune Thyroid ◽

Hashimoto Disease

Abstract Autoimmune thyroid disease (AITD) is one of the most frequent autoimmune disorders. However, the pathogenesis of AITD has not been fully elucidated. Recently, accumulating evidence has demonstrated that abnormal expression of noncoding RNAs (ncRNAs) is closely related to the etiopathogenesis of AITD. microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) are 3 major groups of ncRNAs that are attracting increasing attention. Herein, we summarized our present knowledge on the role of miRNAs, lncRNAs, and circRNAs in AITD. This review focused on the importance of ncRNAs in development of the most prevalent AITD, such as Hashimoto disease and Graves’ diseases. Altogether, the main purpose of this review is to provide new insights in the pathogenesis of AITD and the possibility of developing novel potential therapeutic targets.

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