Emerging Roles for Noncoding RNAs in Autoimmune Thyroid Disease

Abstract Autoimmune thyroid disease (AITD) is one of the most frequent autoimmune disorders. However, the pathogenesis of AITD has not been fully elucidated. Recently, accumulating evidence has demonstrated that abnormal expression of noncoding RNAs (ncRNAs) is closely related to the etiopathogenesis of AITD. microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) are 3 major groups of ncRNAs that are attracting increasing attention. Herein, we summarized our present knowledge on the role of miRNAs, lncRNAs, and circRNAs in AITD. This review focused on the importance of ncRNAs in development of the most prevalent AITD, such as Hashimoto disease and Graves’ diseases. Altogether, the main purpose of this review is to provide new insights in the pathogenesis of AITD and the possibility of developing novel potential therapeutic targets.

Download Full-text

Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

Immunologic Research ◽

10.1007/s12026-014-8598-9 ◽

2014 ◽

Vol 60 (2-3) ◽

pp. 193-200 ◽

Cited By ~ 17

Author(s):

Ivica Lazúrová ◽

Ivana Jochmanová ◽

Karim Benhatchi ◽

Štefan Sotak

Keyword(s):

Rheumatoid Arthritis ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Autoimmune Thyroid

Download Full-text

Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of recepto amino acids ser25-glu30

Immuno-analyse & Biologie Spécialisée ◽

10.1016/s0923-2532(05)80538-1 ◽

1993 ◽

Vol 8 (5) ◽

pp. 327

Keyword(s):

Amino Acids ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Thyrotropin Receptor ◽

Autoimmune Thyroid

Download Full-text

Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers

International Journal of Molecular Sciences ◽

10.3390/ijms23020930 ◽

2022 ◽

Vol 23 (2) ◽

pp. 930

Author(s):

Ba Da Yun ◽

Ye Ji Choi ◽

Seung Wan Son ◽

Gabriel Adelman Cipolla ◽

Fernanda Costa Brandão Berti ◽

...

Keyword(s):

Epithelial To Mesenchymal Transition ◽

Cell Communication ◽

Noncoding Rnas ◽

Long Noncoding Rnas ◽

Circular Rnas ◽

Gastrointestinal Cancers ◽

Gastrointestinal Malignancies ◽

Mesenchymal Transition ◽

Novel Therapeutic Strategies

Circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) are differentially expressed in gastrointestinal cancers. These noncoding RNAs (ncRNAs) regulate a variety of cellular activities by physically interacting with microRNAs and proteins and altering their activity. It has also been suggested that exosomes encapsulate circRNAs and lncRNAs in cancer cells. Exosomes are then discharged into the extracellular environment, where they are taken up by other cells. As a result, exosomal ncRNA cargo is critical for cell–cell communication within the cancer microenvironment. Exosomal ncRNAs can regulate a range of events, such as angiogenesis, metastasis, immune evasion, drug resistance, and epithelial-to-mesenchymal transition. To set the groundwork for developing novel therapeutic strategies against gastrointestinal malignancies, a thorough understanding of circRNAs and lncRNAs is required. In this review, we discuss the function and intrinsic features of oncogenic circRNAs and lncRNAs that are enriched within exosomes.

Download Full-text

Biological functions of long noncoding RNAs and circular RNAs in small-cell lung cancer

Epigenomics ◽

10.2217/epi-2020-0214 ◽

2020 ◽

Vol 12 (19) ◽

pp. 1751-1763

Author(s):

Sachin Kumar ◽

Monu Pandey ◽

Surender K Sharawat

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Noncoding Rnas ◽

Cancer Biomarkers ◽

Small Cell ◽

Long Noncoding Rnas ◽

Circular Rnas ◽

Small Cell Lung

We aim to discuss comprehensively the role of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in small-cell lung cancer (SCLC) biology and their clinical utility as cancer biomarkers. We searched the scientific literature to select articles related to the role of lncRNAs and circRNAs in SCLC biology or as cancer biomarkers. We identified that a number of lncRNAs and circRNAs can regulate key biological processes involved in SCLC development, including cell proliferation, metastasis and chemoresistance mainly acting as miRNA sponges. Also, the expression of a few lncRNAs and circRNAs predicted survival outcome depicting their utility as prognostic biomarkers. Further investigations on the role of lncRNAs and circRNAs in SCLC tumors may yield novel therapeutic targets for SCLC.

Download Full-text