The combined measurements of Higgs boson production and decay are performed based on up to 80 fb[Formula: see text] of proton–proton collision data collected at [Formula: see text] = 13 TeV by the ATLAS detector. The overall signal strength, defined as measured signal yield divided by the Standard Model prediction, is [Formula: see text]. The inclusive and differential cross-sections of gluon–gluon fusion, vector-boson fusion, associated production with vector boson, and associated production with top quarks processes are also measured. The measurements are interpreted with leading-order motivated coupling strength modifiers. No significant deviations from the Standard Model predictions are observed.