Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT

2001 ◽  
Vol 50 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Á Farkas ◽  
L. Kemény ◽  
B.J. Szöny, Zs. Bata-Csörgö ◽  
A. Pivarcsi ◽  
M. Kiss ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Keratinocyte ◽  
Human Keratinocyte Cell Line ◽  
Keratinocyte Cell Line Hacat ◽  
Keratinocyte Cell

scholarly journals Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine:In VitroAppraisal on a Human Keratinocyte Cell Line HaCaT

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
J. Hartinger ◽  
P. Veselý ◽  
E. Matoušková ◽  
S. Argalacsová ◽  
L. Petruželka ◽  
...  
Keyword(s):  
Cell Line ◽  
Local Treatment ◽  
Local Therapy ◽  
Anticancer Therapy ◽  
Protective Activity ◽  
Human Keratinocyte ◽  
Human Keratinocyte Cell Line ◽  
Keratinocyte Cell Line Hacat ◽  
Keratinocyte Cell

5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or its orally applicable prodrug capecitabine. Its severity can even lead to interruption of the otherwise effective anticancer therapy. Tentative practice in some clinics has shown that topical application of 10% uridine ointment is beneficial for calming down the HF syndrome. This study is focused on verifying the alleged protective activity of uridine in thein vitromodel of cultured human keratinocyte cell line HaCaT. We also tested the protective effects of thymidine alone or uridine-thymidine combination. The cellular viability time progression was measured in order to evaluate the effect of protective agents by three different types of cytopathogenicity tests—NTCA test (non-destructive test of cellular activity), modified MTT test and RTCA (real-time cell analyser, Roche). All three methods proved the ability of uridine and uridine-thymidine combination to protect keratinocytes against 5-FU damagein vitro. While thymidine alone did not show any remarkable effect, the thymidine-uridine combination demonstrated enhanced protective activity compared to uridine alone. Our findings provided the supporting rationale for using uridine or uridine-thymidine ointments in the HF syndrome local therapy.

scholarly journals Role of HuR and p38MAPKin Ultraviolet B-induced Post-transcriptional Regulation of COX-2 Expression in the Human Keratinocyte Cell Line HaCaT

2009 ◽  
Vol 285 (6) ◽  
pp. 3896-3904 ◽  
Author(s):  
Niklas S. Fernau ◽  
Dominik Fugmann ◽  
Martin Leyendecker ◽  
Kerstin Reimann ◽  
Susanne Grether-Beck ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Cell Line ◽  
Ultraviolet B ◽  
Human Keratinocyte ◽  
Human Keratinocyte Cell Line ◽  
Keratinocyte Cell Line Hacat ◽  
Keratinocyte Cell ◽  
Cox 2 ◽  
Post Transcriptional Regulation

Induction of apoptosis by synthetic ceramide analogues in the human keratinocyte cell line HaCaT

1998 ◽  
Vol 7 (6) ◽  
pp. 342-349 ◽  
Author(s):  
M. Bektas ◽  
Y. Dullin ◽  
T. Wieder ◽  
T. Kolter ◽  
K. Sandhoff ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Keratinocyte ◽  
Human Keratinocyte Cell Line ◽  
Keratinocyte Cell Line Hacat ◽  
Keratinocyte Cell ◽  
Induction Of Apoptosis

scholarly journals Expression and regulation of phospholipase D in the human keratinocyte cell line HaCaT

FEBS Letters ◽  
1998 ◽  
Vol 425 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Verena Müller-Wieprecht ◽  
Christian Riebeling ◽  
Christian Alexander ◽  
Frank-Rüdiger Scholz ◽  
Ariane Höer ◽  
...  
Keyword(s):  
Cell Line ◽  
Phospholipase D ◽  
Human Keratinocyte ◽  
Human Keratinocyte Cell Line ◽  
Keratinocyte Cell Line Hacat ◽  
Keratinocyte Cell
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