Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists

Mohamed A. H. Ismail; Mohamed Nabil Aboul-Enein; Aida Abd ElSatar El-Azzouny; Khaled A. M. Abouzid; Nasser S. M. Ismail

doi:10.1007/s00044-014-1095-9

Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-014-1095-9 ◽

2014 ◽

Vol 24 (1) ◽

pp. 442-458 ◽

Cited By ~ 1

Author(s):

Mohamed A. H. Ismail ◽

Mohamed Nabil Aboul-Enein ◽

Aida Abd ElSatar El-Azzouny ◽

Khaled A. M. Abouzid ◽

Nasser S. M. Ismail

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

At1 Receptor Antagonists

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Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.01.009 ◽

2012 ◽

Vol 49 ◽

pp. 183-190 ◽

Cited By ~ 19

Author(s):

Jin-Liang Wang ◽

Jun Zhang ◽

Zhi-Ming Zhou ◽

Zhi-Huai Li ◽

Wei-Zhe Xue ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

At1 Receptor ◽

Benzimidazole Derivatives ◽

Receptor Antagonists ◽

Design Synthesis ◽

At1 Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Angiotensin II – AT1 receptor antagonists: Design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2007.11.008 ◽

2008 ◽

Vol 43 (9) ◽

pp. 1808-1812 ◽

Cited By ~ 37

Author(s):

Dhvanit I. Shah ◽

Manu Sharma ◽

Yogita Bansal ◽

Gulshan Bansal ◽

Manjeet Singh

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Benzimidazole Derivatives ◽

Receptor Antagonists ◽

Design Synthesis ◽

At1 Receptor Antagonists

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Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.05.056 ◽

2012 ◽

Vol 20 (14) ◽

pp. 4208-4216 ◽

Cited By ~ 20

Author(s):

Jun Zhang ◽

Jin-Liang Wang ◽

Zhi-Ming Zhou ◽

Zhi-Huai Li ◽

Wei-Zhe Xue ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

At1 Receptor Antagonists

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Synthesis of N-Alkyl-1,2,4-oxadiazinones as Angiotensin-II (AT1) Receptor Antagonists

Heterocycles ◽

10.3987/com-92-6263 ◽

1993 ◽

Vol 36 (5) ◽

pp. 1027 ◽

Cited By ~ 12

Author(s):

Harold N. Weller ◽

Arthur V. Miller ◽

Kenneth E. J. Dickinson ◽

S. Anders Hedberg ◽

Carol L. Delaney ◽

...

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

At1 Receptor Antagonists

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Molecular modelling studies for the discovery of new substituted pyridines derivatives with angiotensin II AT1 receptor antagonists

Interdisciplinary Sciences Computational Life Sciences ◽

10.1007/s12539-013-0201-x ◽

2014 ◽

Vol 6 (3) ◽

pp. 197-207 ◽

Cited By ~ 5

Author(s):

Mukesh C. Sharma

Keyword(s):

Angiotensin Ii ◽

Molecular Modelling ◽

At1 Receptor ◽

Receptor Antagonists ◽

At1 Receptor Antagonists ◽

Molecular Modelling Studies ◽

Substituted Pyridines ◽

Modelling Studies

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Effect of the AT1-Receptor Antagonists Losartan, Irbesartan, and Telmisartan on Angiotensin II-Induced Facilitation of Sympathetic Neurotransmission in the Rat Mesenteric Artery

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-200107000-00015 ◽

2001 ◽

Vol 38 (1) ◽

pp. 141-148 ◽

Cited By ~ 38

Author(s):

Jippe C. Balt ◽

Marie-Jeanne Mathy ◽

Alexander Nap ◽

Martin Pfaffendorf ◽

Pieter A. van Zwieten

Keyword(s):

Angiotensin Ii ◽

Mesenteric Artery ◽

At1 Receptor ◽

Receptor Antagonists ◽

Sympathetic Neurotransmission ◽

Rat Mesenteric Artery ◽

At1 Receptor Antagonists

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Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors

British Journal of Pharmacology ◽

10.1038/sj.bjp.0702398 ◽

1999 ◽

Vol 126 (4) ◽

pp. 1057-1065 ◽

Cited By ~ 115

Author(s):

P M L Vanderheyden ◽

F L P Fierens ◽

J P De Backer ◽

N Fraeyman ◽

G Vauquelin

Keyword(s):

Angiotensin Ii ◽

At1 Receptor ◽

Receptor Antagonists ◽

At1 Receptors ◽

At1 Receptor Antagonists

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Quantitative structure activity relationship analysis of angiotensin II AT1 receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-009-9205-9 ◽

2009 ◽

Vol 19 (5) ◽

pp. 475-489 ◽

Cited By ~ 9

Author(s):

Sarvesh Kumar Paliwal ◽

Mahima Pal ◽

Anees A. Siddiqui

Keyword(s):

Angiotensin Ii ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

At1 Receptor ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Relationship Analysis ◽

Structure Activity ◽

At1 Receptor Antagonists

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Angiotensin II AT1 receptor antagonists and platelet activation

Nephrology Dialysis Transplantation ◽

10.1093/ndt/16.suppl_1.45 ◽

2001 ◽

Vol 16 (suppl_1) ◽

pp. 45-49 ◽

Cited By ~ 30

Author(s):

Antonio López‐Farré ◽

Lourdes Sánchez de Miguel ◽

Mercedes Montón ◽

Ana Jiménez ◽

Almudena Lopez‐Bloya ◽

...

Keyword(s):

Angiotensin Ii ◽

Platelet Activation ◽

At1 Receptor ◽

Receptor Antagonists ◽

At1 Receptor Antagonists

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Design, synthesis, pharmacological evaluation and in silico ADMET prediction of novel substituted benzimidazole derivatives as angiotensin II–AT1 receptor antagonists based on predictive 3D QSAR models

SAR and QSAR in Environmental Research ◽

10.1080/1062936x.2013.868825 ◽

2014 ◽

Vol 25 (2) ◽

pp. 117-146 ◽

Cited By ~ 6

Author(s):

V.K. Vyas ◽

N. Gupta ◽

M. Ghate ◽

S. Patel

Keyword(s):

Angiotensin Ii ◽

In Silico ◽

3D Qsar ◽

At1 Receptor ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Pharmacological Evaluation ◽

At1 Receptor Antagonists ◽

In Silico Admet ◽

Qsar Models

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