Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists

2012 ◽  
Vol 20 (14) ◽  
pp. 4208-4216 ◽  
Author(s):  
Jun Zhang ◽  
Jin-Liang Wang ◽  
Zhi-Ming Zhou ◽  
Zhi-Huai Li ◽  
Wei-Zhe Xue ◽  
...  
Keyword(s):  
Biological Activity ◽  
Angiotensin Ii ◽  
At1 Receptor ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
At1 Receptor Antagonists

Synthesis of N-Alkyl-1,2,4-oxadiazinones as Angiotensin-II (AT1) Receptor Antagonists

Heterocycles ◽  
1993 ◽  
Vol 36 (5) ◽  
pp. 1027 ◽  
Author(s):  
Harold N. Weller ◽  
Arthur V. Miller ◽  
Kenneth E. J. Dickinson ◽  
S. Anders Hedberg ◽  
Carol L. Delaney ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
At1 Receptor ◽  
Receptor Antagonists ◽  
At1 Receptor Antagonists

Design, synthesis and biological activity of 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides as dual angiotensin II and endothelin A receptor antagonists

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 715-718 ◽  
Author(s):  
Li-Ping Hao ◽  
Wei-Zhe Xue ◽  
Xiao-Feng Han ◽  
Xing He ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Angiotensin Ii ◽  
Model Simulation ◽  
Molecular Model ◽  
Pharmacophore Model ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
3D Pharmacophore ◽  
Endothelin A Receptor ◽  
Endothelin A

A series of novel 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides was designed, and their molecular model simulation fitting to a new HipHop 3D pharmacophore model was examined.

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