O-geranylchalcones: synthesis and metabolic inhibition against Leishmania mexicana and Trypanosoma cruzi

2019 ◽  
Vol 29 (1) ◽  
pp. 156-165
Author(s):  
Karla Fabiola Chacon-Vargas ◽  
Velvett G. Domínguez-Méndez ◽  
Benjamín Nogueda-Torres ◽  
David Chávez-Flores ◽  
Alejandro A. Camacho-Dávila ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Metabolic Inhibition ◽  
Leishmania Mexicana

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

2002 ◽  
Vol 125 (1-2) ◽  
pp. 35-45 ◽  
Author(s):  
Julio A Urbina ◽  
Juan Luis Concepcion ◽  
Salomé Rangel ◽  
Gonzalo Visbal ◽  
Renee Lira
Keyword(s):  
Trypanosoma Cruzi ◽  
Squalene Synthase ◽  
Leishmania Mexicana

Seropositivity for Trypanosoma cruzi and Leishmania mexicana in dogs from a metropolitan region of Central Mexico

2020 ◽  
Vol 22 ◽  
pp. 100459
Author(s):  
S. Zamora-Ledesma ◽  
N. Hernández-Camacho ◽  
M. Sánchez-Moreno ◽  
H. Ruiz-Piña ◽  
M.E. Villagrán-Herrera ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Metropolitan Region ◽  
Central Mexico ◽  
Leishmania Mexicana

scholarly journals Anticuerpos de Trypanosoma cruzi, Leishmania mexicana y Leishmania braziliensis en perros domiciliados de Tabasco, México

2017 ◽  
pp. 5829-5836
Author(s):  
Guadalupe Arjona J ◽  
Maritza Zaragoza V ◽  
Claudia Zaragoza V ◽  
Ricardo García Herrera ◽  
Manuel Sánchez M ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Western Blot ◽  
Leishmania Braziliensis ◽  
Leishmania Mexicana

Objetivo. Determinar la frecuencia de anticuerpos circulantes de Trypanosoma cruzi (T. cruzi), Leishmania mexicana (L. mexicana) y Leishmania braziliensis (L. braziliensis) en una población de perros usando ELISA Fe-SOD y Western blot en la región Chontalpa del estado de Tabasco, México. Materiales y métodos. Para este estudio se obtuvieron 119 sueros de perros domiciliados, con el consentimiento previo de los propietarios. Los sueros fueron analizados para detectar anticuerpos contra T. cruzi, L. mexicana, y L. braziliensis, usando como prueba diagnóstica ELISA-sod y Western Blot. La fracción antigénica utilizada en las dos pruebas fue la Fe-SOD excretada por las especies de Trypanosoma y Leishmania. Resultados. La frecuencia obtenida en este estudio fue de 3.36% para T. cruzi, 9.24% para L. mexicana y 10.08% L. braziliensis. Conclusiones. El presente estudio demostró la presencia de anticuerpos para estos parásitos en la región Chontalpa del estado de Tabasco, México.

The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicana

Parasitology ◽  
1983 ◽  
Vol 87 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Mary J. Davies ◽  
A. M. Ross ◽  
W. E. Gutteridge
Keyword(s):  
Trypanosoma Cruzi ◽  
Trypanosoma Brucei ◽  
Broad Spectrum ◽  
Enzyme Activities ◽  
Striking Difference ◽  
Leishmania Mexicana ◽  
Phosphorylase Activity ◽  
Trypanosoma Brucei Brucei ◽  
Purine Salvage ◽  
Salvage Pathways

SUMMARYWe have previously shown the presence of various purine salvage enzymes in Trypanosoma cruzi, including phosphoribosyltransferase, aminohydrolase, kinase, phosphorylase and hydrolase activities. We now report that a similar situation occurs in Leishmania mexicana amazonensis and Trypanosoma brucei brucei. In all three organisms we found higher levels of activity for the phosphoribosyltransferase enzymes than for the nucleoside kinases, suggesting a preference for the salvage of purine bases rather than nucleosides. Similarly, absence of inosine phosphorylase activity suggests that only one route for the salvage of hypoxanthine is available to the three organisms. The most striking difference was that whereas T. cruzi and T. brucei possessed adenosine aminohydrolase activity, this was not detected in L. mexicana; instead adenine amino-hydrolase activity was found. The overall similarity, as judged by the distribution of enzyme activities, of purine salvage in these three members of the kinetoplastida suggest a broad spectrum of activity for any inhibitor acting in this area; the plethora of alternative salvage pathways, however, suggests that in no case would such inhibition be cidal.

scholarly journals Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Jerónimo L. Ulloa ◽  
Renata Spina ◽  
Agustina Casasco ◽  
Patricia B. Petray ◽  
Virginia Martino ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Sesquiterpene Lactones ◽  
Leishmania Mexicana ◽  
Smallanthus Sonchifolius
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