Comparison of seed brachytherapy or external beam radiotherapy (70 Gy or 74 Gy) in 919 low-risk prostate cancer patients

2012 ◽  
Vol 188 (4) ◽  
pp. 305-310 ◽  
Author(s):  
G. Goldner ◽  
R. Pötter ◽  
J.J. Battermann ◽  
M.P. Schmid ◽  
C. Kirisits ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
External Beam Radiotherapy ◽  
Low Risk ◽  
External Beam ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer

How does stereotactic body radiotherapy compare to standard external beam radiotherapy or low-dose rate brachytherapy for low-risk prostate cancer?

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e16070-e16070
Author(s):  
Perakaa Sethukavalan ◽  
Patrick Cheung ◽  
Gerard Morton ◽  
Laura D'Alimonte ◽  
Andrea Deabreu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Stereotactic Body Radiotherapy ◽  
Low Dose ◽  
External Beam Radiotherapy ◽  
Low Risk ◽  
External Beam ◽  
Treatment Type ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer

e16070 Background: Stereotactic body radiotherapy (SBRT) is an emerging radiotherapy technique that appears to be efficacious, well tolerated and convenient. However, outcomes for patients treated with SBRT are unknown compared to more conventional radiation options for patients with prostate cancer. The purpose of this study is to evaluate and compare late toxicities and biochemical disease-free survival (bDFS) of low risk prostate cancer patients treated SBRT (35Gy/5 fractions), standard external beam radiotherapy (STND; median 76Gy/38 fractions) or low-dose brachytherapy (LDR; iodine-125, 145Gy) at the Odette Cancer Centre. Methods: Consecutive patients with low risk prostate cancer treated with radiation from 2006-2008 were analyzed. Patients treated with SBRT were part of a phase 2 prospective clinical trial; patients treated with STND or LDR had data abstracted from medical charts retrospectively. Patients treated with neoadjuvant androgen deprivation therapy were excluded from biochemical analyses. Univariate (UVA) and multivariate analyses (MVA) of Cox proportional hazard model were conducted to identify significant covariates predicting bDFS. Results: A total of 357 low-risk prostate cancer patients were identified (84 SBRT, 81 STND and 192 LDR). The median follow-up was 57, 62, and 59 months, respectively. At baseline, 85% of patients were T1c, 15% T2a; 100% had GS 6; median PSA 5.9 ng/ml. There were more patients in the STND and LDR cohort who had T2a disease (6%, 21% and 16%, p= 0.013) and the mean PSA was higher in the STND cohort (6.08, 6.69, and 6.02, p=0.017). Patients who received LDR experienced more late hematuria (0%, 1.23% and 11.98%, p<0.0001); otherwise there were no significant differences in late toxicities observed. There were no significant differences in bDFS (97.4% vs 96.9% vs 97.2% at 60 months, p=0.94). There were no covariates identified predicting bDFS on UVA or MVA, including treatment type. Conclusions: SBRT, STND and LDR show equivalent effectiveness and both external beam techniques showed less hematuria than LDR. However, SBRT and LDR are more convenient and less costly than STND. Further prospective studies of SBRT are ongoing.

External Beam Radiotherapy for Low-Risk Prostate Cancer

2012 ◽  
pp. 709-717
Author(s):  
Gert O. De Meerleer ◽  
Piet Ost ◽  
Geert M. Villeirs ◽  
Nicolaas Lumen ◽  
Valérie Fonteyne
Keyword(s):  
Prostate Cancer ◽  
External Beam Radiotherapy ◽  
Low Risk ◽  
External Beam ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer

Quality of life in low-risk prostate cancer treated with surgery, external beam radiotherapy, and brachytherapy: A prospective, multicentric cohort study.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e16592-e16592
Author(s):  
Almudena Cascales ◽  
Maria Colmenero ◽  
Alfredo Rodriguez ◽  
Pilar Samper ◽  
Jeanette Valero ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cohort Study ◽  
External Beam Radiotherapy ◽  
Low Risk ◽  
External Beam ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer

Use of Supplemental External Beam Radiotherapy in Men with Low-risk Prostate Cancer undergoing Brachytherapy

2009 ◽  
Vol 75 (3) ◽  
pp. S494
Author(s):  
A.K. Cheung ◽  
M. Chen ◽  
B.J. Moran ◽  
M.H. Braccioforte ◽  
D.E. Dosoretz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
External Beam Radiotherapy ◽  
Low Risk ◽  
External Beam ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer
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