Diagnostic strategies for posttraumatic osteomyelitis: a survey amongst Dutch medical specialists demonstrates the need for a consensus protocol

Since April 1961, all manned space flights have been accompanied by medical control ensuring flight safety. Medical control in space flight has a technological and medical methodology that allows, at a distance from medical specialists, to make an adequate medical decision for the current situation. This work would be impossible if there were no measures taken to unify and standardize equipment and techniques. Telemedicine technologies developed on the basis of flight medical control. The origin of the word telemedicine comes from the expression «telemetric medical information», adopted in space technology. The issues of mutual development and mutual enrichment, standardization of methods and equipment of two areas of medicine, medical control in extreme situations and general telemedicine are considered in this article.

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E6 and E7 oncoproteins: Potential targets of cervical cancer

Current Medicinal Chemistry ◽

10.2174/0929867327666201111145546 ◽

2020 ◽

Vol 27 ◽

Author(s):

Ramarao Malla ◽

Mohammad Amjad Kamal

Keyword(s):

Cervical Cancer ◽

Drug Resistance ◽

Host Cell ◽

Molecular Mechanisms ◽

Immune Therapy ◽

Cervical Lesions ◽

Diagnostic Strategies ◽

E6 And E7 Oncoproteins ◽

E6 And E7

: Cervical cancer (CC) is the fourth leading cancer in women in the age group 15-44 globally. Experimental as well as epidemiological studies identified that type16 and 18 HPV cause 70% of precancerous cervical lesions as well as cervical cancer worldwide by bringing about genetic as well as epigenetic changes in the host genome. The insertion of the HPV genome triggers various defense mechanisms including the silencing of tumor suppressor genes as well as activation of oncogenes associated with cancer metastatic pathway. E6 and E7 are small oncoproteins consisting of 150 and 100 amino acids respectively. These oncoproteins affect the regulation of the host cell cycle by interfering with p53 and pRb. Further these oncoproteins adversely affect the normal functions of the host cell by binding to their signaling proteins. Recent studies demonstrated that E6 and E7 oncoproteins are potential targets for CC. Therefore, this review discusses the role of E6 and E7 oncoproteins in metastasis and drug resistance as well as their regulation, early oncogene mediated signaling pathways. This review also uncovers the recent updates on molecular mechanisms of E6 and E7 mediated phytotherapy, gene therapy, immune therapy, and vaccine strategies as well as diagnosis through precision testing. Therefore, understanding the potential role of E6/E7 in metastasis and drug resistance along with targeted treatment, vaccine, and precision diagnostic strategies could be useful for the prevention and treatment of cervical cancer.

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Common Comorbidities that Alter Heart Failure Prognosis - shaping new thinking for practice.

Current Cardiology Reviews ◽

10.2174/1573403x16666201113093548 ◽

2020 ◽

Vol 16 ◽

Author(s):

Pupalan Iyngkaran ◽

Merlin Thomas ◽

John D Horowitz ◽

Paul Komesaroff ◽

Michael Jelinek ◽

...

Keyword(s):

Heart Failure ◽

Self Management ◽

Community Practice ◽

Elderly Age ◽

Medical Specialists ◽

General Internal ◽

Allied Health Care ◽

Speciality Training ◽

New Thinking ◽

Failure Prognosis

: At least half of all heart failure (CHF) patients will have a comorbidity that could be undertreated, requires additional speciality input and/or polypharmacy. These patients are then at risk from iatrogenic and disease related complications and readmissions if not closely supervised. Common comorbidities of relevance are cardiorenal and cardiometabolic syndromes (DM, obesity, OSA), chronic airways disease, elderly age and accompanying therapeutic optimisation. The structure of community practice often leaves primary, speciality and allied health care in silos. For example, cardiology speciality training in Australia creates excellent sub-specialists to deliver on the diagnostics and therapeutic advances. A casualty of this process has been gradual alienation of general cardiology towards general internal medical specialists and GP's. The consequences are largely noticed in community practice. The issue are compounded by suboptimal communication of information. This review explores these issues from a cardiology sub-speciality lens, firstly cross speciality areas important for cardiologist to maintain their skill and finally a brief overview of disease management and identifying game changing common denominators such as endothelial dysfunction and self-management.

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