Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

Diabetologia ◽  
2022 ◽  
Author(s):  
Lucie Oberhauser ◽  
Cecilia Jiménez-Sánchez ◽  
Jesper Grud Skat Madsen ◽  
Dominique Duhamel ◽  
Susanne Mandrup ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Secretory Response

Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells

Diabetes ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 199-205 ◽  
Author(s):  
F. Purrello ◽  
M. Buscema ◽  
A. M. Rabuazzo ◽  
V. Caltabiano ◽  
F. Forte ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Glucose Transporter ◽  
Secretory Response

scholarly journals Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

1989 ◽  
Vol 86 (12) ◽  
pp. 4505-4509 ◽  
Author(s):  
P. Rorsman ◽  
P. Arkhammar ◽  
K. Bokvist ◽  
C. Hellerstrom ◽  
T. Nilsson ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Secretory Response ◽  
K Channels

Cell-to-cell contact dependence and junctional protein content are correlated with in vivo maturation of pancreatic beta cells

2012 ◽  
Vol 90 (7) ◽  
pp. 837-850 ◽  
Author(s):  
Junia Carolina Santos-Silva ◽  
Carolina Prado de França Carvalho ◽  
Ricardo Beltrame de Oliveira ◽  
Antonio Carlos Boschero ◽  
Carla Beatriz Collares-Buzato
Keyword(s):  
Protein Content ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Secretory Response ◽  
Cell Contact ◽  
Isolated Cells ◽  
Differential Distribution ◽  
Cell Contacts ◽  
Junctional Protein ◽  
Cell Cell

In this study, we investigated the cellular distribution of junctional proteins and the dependence on cell–cell contacts of pancreatic beta cells during animal development. Fetus and newborn rat islets, which display a relatively poor insulin secretory response to glucose, present an immature morphology and cytoarchitecture when compared with young and adult islets that are responsive to glucose. At the perinatal stage, beta cells display a low junctional content of neural cell adhesion molecule (N-CAM), α- and β-catenins, ZO-1, and F-actin, while a differential distribution of N-CAM and Pan-cadherin was seen in beta cells and nonbeta cells only from young and adult islets. In the absence of intercellular contacts, the glucose-stimulated insulin secretion was completely blocked in adult beta cells, but after reaggregation they partially reestablished the secretory response to glucose. By contrast, neonatal beta cells were poorly responsive to sugar, regardless of whether they were arranged as intact islets or as isolated cells. Interestingly, after 10 days of culturing, neonatal beta cells, known to display increased junctional protein content in vitro, became responsive to glucose and concomitantly dependent on cell–cell contacts. Therefore, our data suggest that the developmental acquisition of an adult-like insulin secretory pattern is paralleled by a dependence on direct cell–cell interactions.

Mefloquine, a useful tool to investigate hemichannel function in pancreatic beta cells?

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
N Görgler ◽  
A Welling ◽  
I Rustenbeck
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells

Osteoprotegerin (OPG) protects pancreatic beta cells from Interleukin-1 induced cell death

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
J Schrader ◽  
U Niebergall ◽  
M Schoppet ◽  
D Hörsch ◽  
LC Hofbauer
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Interleukin 1

Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
G Päth ◽  
A Opel ◽  
M Gehlen ◽  
V Rothhammer ◽  
X Niu ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells

Towards Generating Spatiotemporal Multiscale Models of Human Pancreatic Beta Cells

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2171-P
Author(s):  
KATE L. WHITE ◽  
KYLE MCCLARY ◽  
JITIN SINGLA ◽  
RAYMOND C. STEVENS
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Multiscale Models

Diminished Ca2+Signaling, CaV1 Channel Expression, and Activity in Pancreatic Beta Cells Expressing Mutated DISC1 (Disrupted in Schizophrenia 1)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2163-P
Author(s):  
PING LU ◽  
ROHIT B. SHARMA ◽  
LAURA C. ALONSO ◽  
RONGHUA ZHUGE ◽  
ANN R. RITTENHOUSE ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Channel Expression ◽  
Expression And Activity

2195-P: Identification of the Regulatory Mechanism of mTORC1 Signaling Activity in Pancreatic Beta Cells in GCN2 Knockout Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2195-P
Author(s):  
MICHIYO KUDO ◽  
SHUN-ICHIRO ASAHARA ◽  
AYUMI KANNO ◽  
YOSHIAKI KIDO
Keyword(s):  
Beta Cells ◽  
Knockout Mice ◽  
Pancreatic Beta Cells ◽  
Regulatory Mechanism ◽  
Mtorc1 Signaling ◽  
Signaling Activity
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