Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide

2004 ◽  
Vol 16 (9) ◽  
pp. 1109-1116 ◽  
Author(s):  
Riitta Tähtelä ◽  
J. Seppänen ◽  
K. Laitinen ◽  
A. Katajamäki ◽  
J. Risteli ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Type I Collagen ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Bisphosphonate Treatment ◽  
Amino Terminal ◽  
Type I Procollagen ◽  
Serum Type

scholarly journals Serum Bone Resorption Markers after Parathyroidectomy for Renal Hyperparathyroidism: Correlation Analyses for the Cross-Linked N-telopeptide of Collagen I and Tartrate-Resistant Acid Phosphatase

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kuo-Chin Hung ◽  
Chung-Yu Huang ◽  
Chuan-Chieh Liu ◽  
Chih-Jen Wu ◽  
Shao-Yuan Chen ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Bone Resorption ◽  
Type I Collagen ◽  
Bone Alkaline Phosphatase ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Bone Resorption Markers ◽  
Correlation Analyses ◽  
Serum Trap ◽  
The Cross

Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT) with increased serum concentrations of bone resorption markers such as the cross-linked N-telopeptide of type I collagen (NTX) and type-5b tartrate-resistant acid phosphatase (TRAP). When SHPT proves refractory to treatment, parathyroidectomy (PTX) may be needed. Renal patients on maintenance HD who received PTX for refractory SHPT (n=23) or who did not develop refractory SHPT (control subjects;n=25) were followed prospectively for 4 weeks. Serum intact parathyroid hormone (iPTH), NTX, TRAP, and bone alkaline phosphatase (BAP) concentrations were measured serially and correlation analyses were performed. iPTH values decreased rapidly and dramatically. BAP values increased progressively with peak increases observed at 2 weeks after surgery. NTX and TRAP values decreased concurrently and progressively through 4 weeks following PTX. A significant correlation between TRAP and NTX values was observed before PTX but not at 4 weeks after PTX. Additionally, the fractional changes in serum TRAP were larger than those in serum NTX at all times examined after PTX. Serum iPTH, TRAP, and NTX values declined rapidly following PTX for SHPT. Serum TRAP values declined to greater degrees than serum NTX values throughout the 4-week period following PTX.

Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement

2009 ◽  
Vol 130 (4) ◽  
pp. 441-445 ◽  
Author(s):  
Stefan Landgraeber ◽  
Franz Löer ◽  
Hansjörg Heep ◽  
Tim Classen ◽  
Florian Grabellus ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Aseptic Loosening ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Type I Collagen ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Total Hip

Effect of concentric exercise on serum muscle and collagen markers

1993 ◽  
Vol 75 (3) ◽  
pp. 1272-1277 ◽  
Author(s):  
P. Virtanen ◽  
J. T. Viitasalo ◽  
J. Vuori ◽  
K. Vaananen ◽  
T. E. Takala
Keyword(s):  
Type I Collagen ◽  
Male Students ◽  
Type I ◽  
Subsequent Increase ◽  
Collagen Production ◽  
Amino Terminal ◽  
Type I Procollagen ◽  
Concentric Exercise ◽  
Marker Proteins ◽  
Collagen Markers

The effect of an acute bout of high-intensity concentric exercise on serum muscle and collagen marker proteins was studied in nine male students. The muscle-derived serum carbonic anhydrase III, myoglobin, and creatine kinase all increased as a result of the exercise. Serum type I procollagen carboxyterminal propeptide decreased at first but started to increase 2 days after the exercise. Serum galactosylhydroxylysyl glucosyltransferase was elevated immediately after the exercise. No significant changes were seen in the concentrations of serum amino-terminal propeptide of type III procollagen or 4-hydroxyproline. It seems that a single bout of heavy concentric exercise causes protein leakage from muscles and probably from the collagen-synthesizing cells of the connective tissue, which may be accompanied by an initial decrease and a subsequent increase in type I collagen production. The activation of type I collagen production seems to depend on the strain and damage of the musculoskeletal system.

scholarly journals Tartrate-resistant Acid Phosphatase Isoform 5b as Serum Marker for Osteoclastic Activity

2001 ◽  
Vol 47 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Anthony J Janckila ◽  
Karen Takahashi ◽  
Susan Z Sun ◽  
Lung T Yam
Keyword(s):  
Acid Phosphatase ◽  
Type I Collagen ◽  
Bone Alkaline Phosphatase ◽  
Serum Marker ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Enzyme Protein ◽  
Endstage Renal Disease ◽  
Osteoclastic Activity ◽  
Tracp 5B

Abstract Background: Tartrate-resistant acid phosphatase (AcP) 5b is a marker of osteoclastic activity and bone resorption. Immunoassays for serum TRAcP may lack sensitivity and specificity because of the presence of non-bone isoform 5a. The purpose of this study was to isolate the serum isoforms, quantify their disease-related expressions, and test an improved immunoassay for TRAcP 5b. Methods: We separated TRAcP isoforms chromatographically from pooled sera of healthy, rheumatoid arthritis (RA) and endstage renal disease (ESRD) subjects. TRAcP isoforms were identified by electrophoresis and quantified by biochemical and immunochemical assays. Serum TRAcP activity in healthy, RA, and ESRD cohorts was assessed at pH 5.5 and 6.1, and compared with bone alkaline phosphatase (BAP) and N-telopeptides of type I collagen (NTx). Results: TRAcP isoforms 5a and 5b were present in all sera; 5b was identical to osteoclastic TRAcP. In serum from healthy subjects, 5a accounted for 87% of the enzyme protein but only 55% of the activity. In RA, both isoforms were increased two- to threefold in protein, but their specific activities were subnormal. In ESRD, only 5b was abnormal, being increased fivefold in protein and threefold in activity. In RA sera, TRAcP activity did not correlate with either BAP or NTx. In ESRD sera, TRAcP activity correlated with BAP and NTx only when measured at pH 6.1. Conclusions: All sera contained both TRAcP isoforms 5a and 5b, but only 5b was present in bone. TRAcP isoform expression was variable in different diseases. Measurement of TRAcP activity at pH 6.1 improves the specificity of immunoassay for isoform 5b.

scholarly journals Efficacy and Safety of Denosumab Therapy for Osteogenesis Imperfecta Patients with Osteoporosis—Case Series

2018 ◽  
Vol 7 (12) ◽  
pp. 479 ◽  
Author(s):  
Tsukasa Kobayashi ◽  
Yukio Nakamura ◽  
Takako Suzuki ◽  
Tomomi Yamaguchi ◽  
Ryojun Takeda ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Type I Collagen ◽  
Therapeutic Option ◽  
Case Series ◽  
Connective Tissue Disorder ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Mineral Density ◽  
Bone Specific Alkaline Phosphatase ◽  
Amino Terminal

Osteogenesis imperfecta (OI) is a connective tissue disorder that is characterized by low bone density leading to recurrent fractures. The efficacy of the anti-resorption drug denosumab for OI with osteoporosis is still largely unknown. We herein describe the clinical outcomes of eight osteoporotic cases of OI to examine the effects and safety of denosumab. This retrospective, consecutive case series included eight patients respectively aged 42, 40, 14, 22, 3, 51, 37, and 9 years. We measured the bone mineral density (BMD) of the lumbar 1–4 spine (L-BMD) and bilateral hips (H-BMD), bone-specific alkaline phosphatase, urinary type I collagen amino-terminal telopeptide, and tartrate-resistant acid phosphatase 5b before and during denosumab therapy. Despite multiple pretreatment fractures in the cohort, no fractures or severe side effects, such as hypocalcemia, were observed during the observational period apart from a fracture in a young pediatric girl. Both L-BMD and H-BMD were increased by denosumab in seven of eight cases. Bone turnover markers were inhibited in most cases by denosumab therapy. Denosumab treatment could generally raise BMD without any adverse effects. The agent therefore represents a good therapeutic option for OI with osteoporosis.

scholarly journals Serum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxyl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren

1997 ◽  
Vol 43 (9) ◽  
pp. 1577-1581 ◽  
Author(s):  
Patricia M Crofton ◽  
Jean C Wade ◽  
Mervyn R H Taylor ◽  
Celia V Holland
Keyword(s):  
Type I Collagen ◽  
Reference Intervals ◽  
Type I ◽  
High Turnover ◽  
Childhood Growth ◽  
Type Iii ◽  
Procollagen Type ◽  
Amino Terminal ◽  
Type I Procollagen ◽  
Carboxyl Terminal

Abstract We report pediatric age- and sex-specific 95% reference intervals for procollagen type I C-terminal propeptide (PICP), the cross-linked C-terminal telopeptide of type I collagen (ICTP), and procollagen type III N-terminal propeptide (P3NP), measured in plasma from 302 schoolchildren (156 boys, 146 girls) ages 4–19 years. All three markers displayed a significant variation with age (ANOVA P ≤0.0015). PICP showed no detectable increase during adolescence for either sex, but decreased towards adult concentrations after the age of puberty, with an earlier decrease for girls than for boys (P <0.01). ICTP and P3NP both increased in pubertal-aged children (P <0.05), with an earlier increase in girls than in boys (P <0.05), before decreasing towards adult concentrations (P <0.01). All three collagen markers were highly correlated with one another (P <0.001). The patterns observed mirrored the childhood growth curve and reflected the high turnover of bone and soft tissue during childhood growth.

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