Effects of typical and atypical antipsychotics on glucose–insulin homeostasis and lipid metabolism in first-episode schizophrenia

2006 ◽  
Vol 186 (4) ◽  
pp. 572-578 ◽  
Author(s):  
Ren-Rong Wu ◽  
Jing-Ping Zhao ◽  
Zhe-Ning Liu ◽  
Jin-Guo Zhai ◽  
Xiao-Feng Guo ◽  
...  
2008 ◽  
Vol 102 (1-3) ◽  
pp. 5
Author(s):  
Philip R. Szeszko ◽  
Catherine L. Narr ◽  
Owen R. Phillips ◽  
Joanne McCormack ◽  
Serge Sevy ◽  
...  

2011 ◽  
Vol 31 (2) ◽  
pp. 146-153 ◽  
Author(s):  
Geartsje Boonstra ◽  
Neeltje E.M. van Haren ◽  
Hugo G. Schnack ◽  
Wiepke Cahn ◽  
Huibert Burger ◽  
...  

2010 ◽  
Vol 117 (2-3) ◽  
pp. 223
Author(s):  
Geartsje Boonstra ◽  
Neeltje E.M. van Haren ◽  
Hugo G. Schnack ◽  
Wiepke Cahn ◽  
Huibert Burger ◽  
...  

2005 ◽  
Vol 30 (4) ◽  
pp. 765-774 ◽  
Author(s):  
Paola Dazzan ◽  
Kevin D Morgan ◽  
Ken Orr ◽  
Gerard Hutchinson ◽  
Xavier Chitnis ◽  
...  

2012 ◽  
Vol 54 (3) ◽  
pp. 248 ◽  
Author(s):  
Amresh Shrivastava ◽  
Kristen Terpstra ◽  
Larry Stitt ◽  
Nilesh Shah ◽  
Megan Johnston

Author(s):  
Julia Furtner ◽  
Veronika Schöpf ◽  
Andreas Erfurth ◽  
Gabriele Sachs

Summary Objective The purpose of our functional magnetic resonance imaging (fMRI) study was to examine brain activity using a “1-back” paradigm as working memory task in drug-naïve subjects with first episode schizophrenia before and after cognitive remediation training. Methods In this study 15 drug-naïve first episode subjects who met DSM-IV criteria for schizophrenia were randomized to receive either atypical antipsychotics (AP, n = 8) or atypical antipsychotics in combination with cognitive remediation therapy (AP + CR, n = 7), 11 subjects had a follow-up fMRI examination after therapy (AP, n = 5; AP + CR, n = 6). Results In 4 of the 6 AP + CR subjects the number of activation clusters increased, whereas in 4 out of the 5 AP subjects the number of clusters decreased (mean number of clusters: AP + CR = 5.53, SD 12.79, AP = −5.8, SD 6.9). Conclusion In this randomized study the number of activation clusters during a working memory task increased after cognitive remediation training. Our data show that neurobiological effects of cognitive remediation can be identified in the very early course of schizophrenia.


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