scholarly journals Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task

2006 ◽  
Vol 189 (2) ◽  
pp. 211-223 ◽  
Author(s):  
E. Hoyle ◽  
R. F. Genn ◽  
C. Fernandes ◽  
I. P. Stolerman
Keyword(s):  
Reaction Time ◽  
Knockout Mice ◽  
Nicotinic Receptor ◽  
Reaction Time Task ◽  
Serial Reaction Time Task ◽  
Serial Reaction Time ◽  
Impaired Performance ◽  
Time Task ◽  
Serial Reaction ◽  
Alpha7 Nicotinic Receptor

scholarly journals Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD

2021 ◽  
Author(s):  
Chiara Toschi ◽  
Mona El-Sayed Hervig ◽  
Parisa Moazen ◽  
Maximilian G. Parker ◽  
Jeffrey W. Dalley ◽  
...  
Keyword(s):  
Reaction Time ◽  
Reaction Time Task ◽  
Serial Reaction Time Task ◽  
Superior Performance ◽  
Serial Reaction Time ◽  
Impaired Performance ◽  
Time Task ◽  
Serial Reaction ◽  
Behavioural Profile ◽  
Improved Performance

Abstract Background Work in humans has shown that impulsivity can be advantageous in certain settings. However, evidence for so-called functional impulsivity is lacking in experimental animals. Aims This study investigated the contexts in which high impulsive (HI) rats show an advantage in performance compared with mid- (MI) and low impulsive (LI) rats. We also assessed the effects of dopaminergic and noradrenergic agents to investigate underlying neurotransmitter mechanisms. Methods We tested rats on a variable inter-trial interval (ITI) version of the 5-choice serial reaction time task (5CSRTT). Rats received systemic injections of methylphenidate (MPH, 1 mg/kg and 3 mg/kg), atomoxetine (ATO, 0.3 mg/kg and 1 mg/kg), amphetamine (AMPH, 0.2 mg/kg), the alpha-2a adrenoceptor antagonist atipamezole (ATI, 0.3 mg/kg) and the alpha-1 adrenoceptor agonist phenylephrine (PHEN, 1 mg/kg) prior to behavioural testing. Results Unlike LI rats, HI rats exhibited superior performance, earning more reinforcers, on short ITI trials, when the task required rapid responding. MPH, AMPH and ATI improved performance on short ITI trials and increased impulsivity in long ITI trials, recapitulating the behavioural profile of HI. In contrast, ATO and PHEN impaired performance on short ITI trials and decreased impulsivity, thus mimicking the behavioural profile of LI rats. The effects of ATO were greater on MI rats and LI rats. Conclusions These findings indicate that impulsivity can be advantageous when rapid focusing and actions are required, an effect that may depend on increased dopamine neurotransmission. Conversely, activation of the noradrenergic system, with ATO and PHEN, led to a general inhibition of responding.

External feedback on performance in a serial reaction time task

2011 ◽  
Author(s):  
K. Homble ◽  
J. Vandenbossche ◽  
E. Soetens ◽  
N. Deroost
Keyword(s):  
Reaction Time ◽  
Reaction Time Task ◽  
Serial Reaction Time Task ◽  
Serial Reaction Time ◽  
External Feedback ◽  
Time Task ◽  
Serial Reaction

The feasibility and efficacy of a serial reaction time task that measures motor learning of anticipatory stepping

2021 ◽  
Vol 86 ◽  
pp. 346-353
Author(s):  
Geneviève N. Olivier ◽  
Serene S. Paul ◽  
Christopher S. Walter ◽  
Heather A. Hayes ◽  
K. Bo Foreman ◽  
...  
Keyword(s):  
Reaction Time ◽  
Motor Learning ◽  
Reaction Time Task ◽  
Serial Reaction Time Task ◽  
Serial Reaction Time ◽  
Time Task ◽  
Serial Reaction

Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats

2007 ◽  
Vol 53 (8) ◽  
pp. 930-941 ◽  
Author(s):  
Harlan E. Shannon ◽  
Elizabeth L. Eberle ◽  
Charles H. Mitch ◽  
David L. McKinzie ◽  
Michael A. Statnick
Keyword(s):  
Reaction Time ◽  
Opioid Receptor ◽  
Reaction Time Task ◽  
Serial Reaction Time Task ◽  
Kappa Opioid Receptor ◽  
Serial Reaction Time ◽  
Kappa Opioid ◽  
Time Task ◽  
Serial Reaction ◽  
Opioid Receptor Agonists
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