The role of the right dorsolateral prefrontal cortex in the Tower of London task performance: repetitive transcranial magnetic stimulation study in patients with Parkinson’s disease

2012 ◽  
Vol 223 (2) ◽  
pp. 251-257 ◽  
Author(s):  
H. Srovnalova ◽  
R. Marecek ◽  
R. Kubikova ◽  
I. Rektorova
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Task Performance ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Tower Of London ◽  
Dorsolateral Prefrontal ◽  
The Right

scholarly journals The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Daniela Mannarelli ◽  
Caterina Pauletti ◽  
Antonello Grippo ◽  
Aldo Amantini ◽  
Vito Augugliaro ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Contingent Negative Variation ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Phasic Alertness ◽  
Dorsolateral Prefrontal ◽  
Related Potentials ◽  
The Right

Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (DLPFC) during the attentional processing of a stimulus using a cued double-choice reaction time task. The evaluation of these processes was conducted by means of Event-Related Potentials (ERPs), in particular by using the Contingent Negative Variation (CNV), and repetitive 1-Hz Transcranial Magnetic Stimulation (rTMS). Transient virtual inhibition of the right DLPFC induced by real 1-Hz rTMS stimulation led to a significant decrease in total CNV and W1-CNV areas if compared with the basal and post-sham rTMS conditions. Reaction times (RTs) did not decrease after inhibitory rTMS, but they did improve after sham stimulation. These results suggest that the right DLPFC plays a crucial role in the genesis and maintenance of the alerting state and learning processes.

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