Rule-dependent neuronal activity in the prefrontal cortex

1999 ◽  
Vol 126 (3) ◽  
pp. 315-335 ◽  
Author(s):  
Ilsun M. White ◽  
S. P. Wise
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity

Systemic morphine and local opioid effects on neuronal activity in the medial prefrontal cortex

Neuroscience ◽  
1996 ◽  
Vol 70 (4) ◽  
pp. 941-949 ◽  
Author(s):  
J.L. Giacchino ◽  
S.J. Henriksen
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Neuronal Activity

scholarly journals Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Luca F. Kaiser ◽  
Theo O. J. Gruendler ◽  
Oliver Speck ◽  
Lennart Luettgau ◽  
Gerhard Jocham
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Ventromedial Prefrontal Cortex ◽  
Anterior Cingulate ◽  
Mutual Inhibition ◽  
Dorsal Anterior Cingulate Cortex ◽  
Cortical Excitation ◽  
The Cost

AbstractIn a dynamic world, it is essential to decide when to leave an exploited resource. Such patch-leaving decisions involve balancing the cost of moving against the gain expected from the alternative patch. This contrasts with value-guided decisions that typically involve maximizing reward by selecting the current best option. Patterns of neuronal activity pertaining to patch-leaving decisions have been reported in dorsal anterior cingulate cortex (dACC), whereas competition via mutual inhibition in ventromedial prefrontal cortex (vmPFC) is thought to underlie value-guided choice. Here, we show that the balance between cortical excitation and inhibition (E/I balance), measured by the ratio of GABA and glutamate concentrations, plays a dissociable role for the two kinds of decisions. Patch-leaving decision behaviour relates to E/I balance in dACC. In contrast, value-guided decision-making relates to E/I balance in vmPFC. These results support mechanistic accounts of value-guided choice and provide evidence for a role of dACC E/I balance in patch-leaving decisions.

Cerebral Processing of Acute Skin and Muscle Pain in Humans

1997 ◽  
Vol 78 (1) ◽  
pp. 450-460 ◽  
Author(s):  
Peter Svensson ◽  
Satoshi Minoshima ◽  
Ahmad Beydoun ◽  
Thomas J. Morrow ◽  
Kenneth L. Casey
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Muscle Pain ◽  
Pain Threshold ◽  
Premotor Cortex ◽  
High Energy ◽  
Anterior Cingulate ◽  
Noxious Stimulation ◽  
Cutaneous Stimulation ◽  
Cerebral Processing

Svensson, Peter, Satoshi Minoshima, Ahmad Beydoun, Thomas J. Morrow, and Kenneth L. Casey. Cerebral processing of acute skin and muscle pain in humans. J. Neurophysiol. 78: 450–460, 1997. The human cerebral processing of noxious input from skin and muscle was compared with the use of positron emission tomography with intravenous H2 15O to detect changes in regional cerebral blood flow (rCBF) as an indicator of neuronal activity. During each of eight scans, 11 normal subjects rated the intensity of stimuli delivered to the nondominant (left) forearm on a scale ranging from 0 to 100 with 70 as pain threshold. Cutaneous pain was produced with a high-energy CO2 laser stimulator. Muscle pain was elicited with high-intensity intramuscular electrical stimulation. The mean ratings of perceived intensity for innocuous and noxious stimulation were32.6 ± 4.5 (SE) and 78.4 ± 1.7 for cutaneous stimulation and 15.4 ± 4.2 and 73.5 ± 1.4 for intramuscular stimulation. The pain intensity ratings and the differences between noxious and innocuous ratings were similar for cutaneous and intramuscular stimuli ( P > 0.05). After stereotactic registration, statistical pixel-by-pixel summation ( Z score) and volumes-of-interest (VOI) analyses of subtraction images were performed. Significant increases in rCBF to both noxious cutaneous and intramuscular stimulation were found in the contralateral secondary somatosensory cortex (SII) and inferior parietal lobule [Brodmann area (BA) 40]. Comparable levels of rCBF increase were found in the contralateral anterior insular cortex, thalamus, and ipsilateral cerebellum. Noxious cutaneous stimulation caused significant activation in the contralateral lateral prefrontal cortex (BA 10/46) and ipsilateral premotor cortex (BA 4/6). Noxious intramuscular stimulation evoked rCBF increases in the contralateral anterior cingulate cortex (BA 24) and subsignificant responses in the contralateral primary sensorimotor cortex (MI/SI) and lenticular nucleus. These activated cerebral structures may represent those recruited early in nociceptive processing because both forms of stimuli were near pain threshold. Correlation analyses showed a negative relationship between changes in rCBF for thalamus and MI/SI for cutaneous stimulation, and positive relationships between thalamus and anterior insula for both stimulus modalities. Direct statistical comparisons between innocuous cutaneous and intramuscular stimulation with the use of Z scores and VOI analyses showed no reliable differences between these two forms of noxious stimulation, indicating a substantial overlap in brain activation pattern. The comparison of noxious cutaneous and intramuscular stimulation indicated more activation in the premotor cortex, SII, and prefrontal cortex with cutaneous stimulation, but these differences did not reach statistical significance. The similar cerebral activation patterns suggest that the perceived differences between acute skin and muscle pain are mediated by differences in the intensity and temporospatial pattern of neuronal activity within similar sets of forebrain structures.

scholarly journals Neuronal Activity during a Cued Strategy Task: Comparison of Dorsolateral, Orbital, and Polar Prefrontal Cortex

2012 ◽  
Vol 32 (32) ◽  
pp. 11017-11031 ◽  
Author(s):  
S. Tsujimoto ◽  
A. Genovesio ◽  
S. P. Wise
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity

Properties of delay-period neuronal activity in the primate prefrontal cortex during memory- and sensory-guided saccade tasks

2004 ◽  
Vol 19 (2) ◽  
pp. 447-457 ◽  
Author(s):  
Satoshi Tsujimoto ◽  
Toshiyuki Sawaguchi
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Delay Period

scholarly journals Social defeat stress causes selective attenuation of neuronal activity in the ventromedial prefrontal cortex

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Reimi Abe ◽  
Sakura Okada ◽  
Ryota Nakayama ◽  
Yuji Ikegaya ◽  
Takuya Sasaki
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Social Defeat ◽  
Ventromedial Prefrontal Cortex ◽  
Social Defeat Stress

Acquisition, Extinction, and Recall of Opiate Reward Memory Are Signaled by Dynamic Neuronal Activity Patterns in the Prefrontal Cortex

2011 ◽  
Vol 21 (12) ◽  
pp. 2665-2680 ◽  
Author(s):  
N. Sun ◽  
N. Chi ◽  
N. Lauzon ◽  
S. Bishop ◽  
H. Tan ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Activity Patterns

scholarly journals An Integrate-and-fire Model of Prefrontal Cortex Neuronal Activity during Performance of Goal-directed Decision Making

2005 ◽  
Vol 15 (12) ◽  
pp. 1964-1981 ◽  
Author(s):  
Randal A. Koene ◽  
Michael E. Hasselmo
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Fire Model ◽  
Integrate And Fire
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