Teriparatide Treatment in Patients with Pregnancy- and Lactation-Associated Osteoporosis

Author(s):  
Kalliopi Lampropoulou-Adamidou ◽  
Georgios Trovas ◽  
Ioannis K. Triantafyllopoulos ◽  
Maria P. Yavropoulou ◽  
Athanasios D. Anastasilakis ◽  
...  
HORMONES ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 495-500 ◽  
Author(s):  
Kalliopi Lampropoulou-Adamidou ◽  
George Trovas ◽  
Ioannis Stathopoulos ◽  
Nikolaos Papaioannou

2013 ◽  
Author(s):  
Kalliopi Lampropoulou-Adamidou ◽  
Christos Kosmidis ◽  
Stathopoulos Ioannis P ◽  
Papaioannou Nikolaos A ◽  
George Trovas

1962 ◽  
Vol 40 (3) ◽  
pp. 430-440 ◽  
Author(s):  
K. E. Arosenius ◽  
H. Derblom ◽  
G. Nylander

ABSTRACT The offspring of bitches treated with thiouracil during pregnancy and lactation were studied with regard to certain aspects of iodine metabolism and also to the morphological effect on the thyroid gland, as compared with controls of the same age and weight. At the age of six months, when the dogs were virtually fully grown, the thyroid gland still exhibited the effects of the thiouracil treatment of the mothers as manifested by an increased uptake of 131I, enlargement, and histological changes of a hyperplastic type. The significance of these deviations from normal iodine metabolism and morphology is discussed with particular reference to the dangers of thiouracil medication during pregnancy.


Author(s):  
Tomaz Kocjan ◽  
Antonela Sabati Rajic ◽  
Mojca Jensterle Sever ◽  
Gaj Vidmar ◽  
Barbara Ostanek ◽  
...  

Author(s):  
Emanuele Cozzani ◽  
Margherita Cioni ◽  
Lodovica Gariazzo ◽  
Martina Burlando ◽  
Aurora Parodi

2020 ◽  
Vol 17 (1) ◽  
pp. 28-37
Author(s):  
Tabinda Sattar

Background: Selenium is a micronutrient, although required in low amounts, its importance in male and female reproduction is well known. Objectives: The core purpose of this study is to evaluate the role of selenium in human reproduction, during pregnancy/ lactation in women and newborns. The review explains side by side the sources of selenium, required amounts of selenium in humans and during pregnancy or lactation. Methods: Selenium deficiency is a major cause of male infertility. Similarly, selenium deficiency, both in pregnant and postpartum women, would greatly affect the health of the newborn baby in all respects. The effect of maternal selenium upon the fetus and the neonates even one year after birth has been explained with some recent examples. Results: The study elaborates the fact that the selenium deficiency in pregnancy and lactation is common due to fetal/infant development, so selenium supplements must be provided in order to overcome these deficiency symptoms. Conclusions: The better reproductive health in humans is possible due to the sufficient amounts of selenium present both in males and females as well.


Author(s):  
Changjun Chen ◽  
Mohammed Alqwbani ◽  
Jie Chen ◽  
Ruitong Yang ◽  
Songgang Wang ◽  
...  

Objective: The objective of this meta-analysis was to compare the efficacy and safety of teriparatide versus salmon calcitonin for the treatment of osteoporosis in Asian patients and to investigate whether the results of global studies could be applicable to Asian patients. Methods: PubMed, OVID, Cochrane Central Register of Controlled Trials (CENTRAL) and EMBASE up to December 2018 were searched. Eligible randomized controlled trials (RCTs) that compared teriparatide versus salmon calcitonin in Asian osteoporosis popula-tion were included. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for data synthe-sis, and Cochrane Collaboration software Review Manager 5.3 was used to analyze the pooled data. Results: Three RCTs involving 529 patients were included (mean age 68.7 yr; 93.4% females; mean follow-up 6 months); outcome measures included bone mineral density (BMD) of the femoral neck, total hip and lumbar spine; bone markers and adverse events. We found that the period of 6-months of teriparatide treatment was helpful for the improvement of the BMD of lumbar vertebra, however, the improvement of BMD was not significant in femoral neck and total hip join. There was a positive correlation between bone-specific alka-line phosphatase (BSAP) and osteocalcin (OCN) and the response of Asian patients to subcutaneous injection of 20 micrograms per day of teriparatide. And the proportion of the occurrence of adverse effect was more obvious in teriparatide group compared with salmon calciton-in, but there was no significant difference. Conclusion: Results suggested that the use of teriparatide could improve the lumbar BMD by short-term (six months) application in Asian osteoporosis patients, which is beneficial to the patients who cannot tolerate adverse events of long-term treatment. The BSAP and OCN bone markers could be useful to monitor the responses of Asian osteoporosis patients to teriparatide treatment. Finally, both of teriparatide and salmon calcitonin were well tolerated by Asian patients.


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