THIOURACIL TREATMENT IN PREGNANCY AND LACTATION IN THE DOG

1962 ◽  
Vol 40 (3) ◽  
pp. 430-440 ◽  
Author(s):  
K. E. Arosenius ◽  
H. Derblom ◽  
G. Nylander
Keyword(s):  
Thyroid Gland ◽  
List Type ◽  
Histological Changes ◽  
Morphological Effect ◽  
Iodine Metabolism ◽  
Pregnancy And Lactation ◽  
In Pregnancy

ABSTRACT The offspring of bitches treated with thiouracil during pregnancy and lactation were studied with regard to certain aspects of iodine metabolism and also to the morphological effect on the thyroid gland, as compared with controls of the same age and weight. At the age of six months, when the dogs were virtually fully grown, the thyroid gland still exhibited the effects of the thiouracil treatment of the mothers as manifested by an increased uptake of 131I, enlargement, and histological changes of a hyperplastic type. The significance of these deviations from normal iodine metabolism and morphology is discussed with particular reference to the dangers of thiouracil medication during pregnancy.

DER EINFLUSS VON RESERPIN AUF DIE ANTITHYREOIDALE WIRKUNG VON KALIUMPERCHLORAT

1962 ◽  
Vol 39 (3) ◽  
pp. 423-430
Author(s):  
H. L. Krüskemper ◽  
F. J. Kessler ◽  
E. Steinkrüger
Keyword(s):  
Thyroid Gland ◽  
Male Rats ◽  
Normal Male ◽  
Tissue Respiration ◽  
List Type ◽  
Morphological Alterations ◽  
Hormone Synthesis ◽  
Stimulation Of

ABSTRACT 1. Reserpine does not inhibit the tissue respiration of liver in normal male rats (in vitro). 2. The decrease of tissue respiration of the liver with simultaneous morphological stimulation of the thyroid gland after long administration of reserpine is due to a minute inhibition of the hormone synthesis in the thyroid gland. 3. The morphological alterations of the thyroid in experimental hypothyroidism due to perchlorate can not be prevented with reserpine.

CAPILLARY PATTERN OF THE THYROID GLAND IN THE RAT IN FUNCTIONAL BLOCK

1962 ◽  
Vol 40 (3) ◽  
pp. 441-450 ◽  
Author(s):  
K. E. Arosenius ◽  
G. Nylander
Keyword(s):  
Thyroid Gland ◽  
Control Group ◽  
List Type ◽  
Epithelial Hyperplasia ◽  
Intact Control ◽  
Functional Block ◽  
Propyl Thiouracil

ABSTRACT The capillary pattern of the thyroid gland was studied in the rat: one group had undergone hemithyroidectomy, one was treated with propyl thiouracil, and one subjected to both these experimental measures. Histological and microangiographic observations were compared with those in an intact control group. Epithelial hyperplasia and other morphological signs of activity were seen to a moderate extent in the hemithyroidectomized group, were marked in the rats treated with thiouracil, and most marked in the group subjected to both thiouracil medication and hemithyroidectomy. The appearances of the interfollicular capillaries showed no perceptible changes in the group subjected solely to hemithyroidectomy. Changes of the interfollicular capillaries were marked in all the animals treated with propyl thiouracil. In the group only treated with propyl thiouracil, the capillaries were dilated to sinusoid-like blood pools in limited segments between which the capillaries were of normal width. In the group subjected to both hemithyroidectomy and propyl thiouracil treatment the interfollicular capillaries were dilated throughout their course. The significance of these morphological and microangiographic observations is discussed.

A COMPARATIVE STUDY OF IODINE METABOLISM IN PREGNANCY, SPORADIC GOITRE AND THYROTOXICOSIS

1965 ◽  
Vol 48 (1) ◽  
pp. 14-22 ◽  
Author(s):  
S. A. Aboul-Khair ◽  
J. Crooks
Keyword(s):  
Comparative Study ◽  
Pregnant Women ◽  
Iodine Deficiency ◽  
Physiological Responses ◽  
Iodine Uptake ◽  
Thyroid Activity ◽  
Deficiency State ◽  
Iodine Metabolism ◽  
Inorganic Iodine ◽  
In Pregnancy

ABSTRACT Studies of iodine metabolism have been carried out in 15 pregnant women, 33 cases with sporadic goitre and 11 with thyrotoxicosis. A low plasma inorganic iodine was common to the three groups. In pregnancy and sporadic goitre the thyroid clearance of iodine was elevated and the absolute iodine uptake normal. A high thyroid clearance of iodine in thyrotoxicosis was associated with a high absolute iodine uptake. The results suggest that both pregnancy and sporadic goitre are physiological responses to an iodine deficiency state while the iodine deficiency state of thyrotoxicosis is secondary to increased thyroid activity.

A systematic review of the use of prazosin in pregnancy and lactation

2021 ◽  
Author(s):  
Ashley D. Davidson ◽  
Amritha Bhat ◽  
Frances Chu ◽  
Jessie N. Rice ◽  
N. Aba Nduom ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy And Lactation ◽  
In Pregnancy

scholarly journals IODINE METABOLISM OF THE THYROID GLAND

1942 ◽  
Vol 142 (2) ◽  
pp. 905-912 ◽  
Author(s):  
Walter Mann ◽  
Charles P. Leblond ◽  
Stafford L. Warren
Keyword(s):  
Thyroid Gland ◽  
Iodine Metabolism

scholarly journals The exposure to biologic and targeted synthetic disease-modifying antirheumatic drugs in pregnancy and lactation

2020 ◽  
Vol 37 (3) ◽  
pp. 306-312 ◽  
Author(s):  
Alicja Góralczyk ◽  
Katarzyna Kolossa ◽  
Marzena Waszczak-Jeka ◽  
Rafał Adamczak ◽  
Sławomir Jeka
Keyword(s):  
Disease Modifying Antirheumatic Drugs ◽  
Antirheumatic Drugs ◽  
Pregnancy And Lactation ◽  
Disease Modifying ◽  
In Pregnancy

The influence of intake of dietary energy in pregnancy and lactation upon sow productivity

1968 ◽  
Vol 71 (2) ◽  
pp. 215-222 ◽  
Author(s):  
F. W. H. Elsley ◽  
R. M. MacPherson ◽  
I. McDonald
Keyword(s):  
Daily Intake ◽  
Dietary Energy ◽  
Large White ◽  
Treatment Groups ◽  
Daily Energy ◽  
Reproductive Life ◽  
Pregnancy And Lactation ◽  
Daily Intakes ◽  
Practical Implications ◽  
In Pregnancy

SUMMARYFifty-two Large White gilts, arranged in thirteen groups of four litter sisters, were allocated at mating to one of four treatment groups. These treatments, arranged as a 2 × 2 factorial, allowed daily energy intakes in pregnancy of 8·3 Meal (H(e)) or 5·2 Meal (L(e)) and of average daily intake during lactation of 20 Meal (h(e)) or 13·8 Meal (m(e)). Daily intakes of protein, minerals and vitamins were similar for all treatments. There were no consistent differences in health or breeding regularity between the treatments.The H(e) sows had a net gain in pregnancy 22 kg greater than the L(e) sows. Feeding the higher level in lactation (h(e) resulted in a reduced sow weight loss during lactation of 20, 12 and 10 kg in the first, second and third parities respectively, as compared with the m(e) sows. There were no consistent effects on the numbers of pigs born apart from the first litter in which L(e) sows produced significantly larger litters at birth. The higher energy intakes in pregnancy and lactation led to very similar increases in the weights of the piglets, of the order of 0.1 kg at birth, 0.4 kg at 3 weeks of age, and 1.1 kg at 8 weeks of age. Sowsgiven the same overall energy intake throughout their reproductive life (H(e) m(e), L(e) h(e)) at the end of the third litter had similar live weights and had produced a similar total weight of weaned pigs. The practical implications of these results are discussed.

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