The role of qualitative and quantitative MRI assessment of multiple sclerosis lesions according to their in evaluating the efficacy of intravenous immunoglobulin G

2004 ◽  
Vol 46 (4) ◽  
pp. 287-290 ◽  
Author(s):  
S. Yildirim-G�rel ◽  
E. T. Tali ◽  
S. Isik ◽  
C. Irke� ◽  
B. Ko�er
Keyword(s):  
Multiple Sclerosis ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
Quantitative Mri ◽  
Qualitative And Quantitative ◽  
Intravenous Immunoglobulin G

A double-blind, cross-over trial of intravenous immunoglobulin G in multiple sclerosis: Preliminary results

1997 ◽  
Vol 3 (2) ◽  
pp. 145-148 ◽  
Author(s):  
P. Soelberg Sørensen ◽  
B. Wanscher ◽  
K. Schreiber ◽  
M. Blinkenberg ◽  
C.V. Jensen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
Progressive Multiple Sclerosis ◽  
Ivig Treatment ◽  
Double Blind Study ◽  
Intravenous Methylprednisolone ◽  
Double Blind ◽  
Relapsing Remitting ◽  
Intravenous Immunoglobulin G

We enrolled 25 patients with relapsing-remitting or relapsing progressive multiple sclerosis (MS) in a randomized placebo-controlled double-blind study of intravenous immunoglobulin G (IVIG). IVIG Iglkg daily for 2 days was administered every 4 weeks for 24 weeks. Seventeen patients completed the whole trial, whereas eight patients discontinued the trial; four during IVIG treatment and four on placebo. Of the 17 patients who completed the trial, II had no exacerbations during IVIG treatment compared with only six on placebo (P=0.05). The total number of exacerbations in the IVIG period was I / and in the placebo period 15 (NS), and the number of severe exacerbations requiring treatment with intravenous methylprednisolone was four during treatment with IVIG and six on placebo (NS). The results suggest that IVIG treatment may be of beneft for prevention of exacerbations in patients with relapsing MS.

Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis

Neurology ◽  
1998 ◽  
Vol 50 (5) ◽  
pp. 1273-1281 ◽  
Author(s):  
P. S. Sorensen ◽  
B. Wanscher ◽  
C. V. Jensen ◽  
K. Schreiber ◽  
M. Blinkenberg ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
Intravenous Immunoglobulin G ◽  
Relapsing Multiple Sclerosis

Neonatal autoimmune thrombocytopenia: role of high-dose intravenous immunoglobulin G therapy

1989 ◽  
Vol 59 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Victor Blanchette ◽  
Maureen Andrew ◽  
Max Perlman ◽  
Emily Ling ◽  
Ami Ballin
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
High Dose ◽  
Autoimmune Thrombocytopenia ◽  
Intravenous Immunoglobulin G

A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome

1990 ◽  
Vol 89 (5) ◽  
pp. 554-560 ◽  
Author(s):  
Phillip K. Peterson ◽  
Judy Shepard ◽  
Mark Macres ◽  
Carlos Schenck ◽  
John Crosson ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Intravenous Immunoglobulin G

scholarly journals Comparison of Fc N-Glycosylation of Pharmaceutical Products of Intravenous Immunoglobulin G

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139828 ◽  
Author(s):  
Willem Jan R. Fokkink ◽  
David Falck ◽  
Tom C. M. Santbergen ◽  
Ruth Huizinga ◽  
Manfred Wuhrer ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin G ◽  
Pharmaceutical Products ◽  
Intravenous Immunoglobulin G

scholarly journals Brain and Spinal Cord MRI in Multiple Sclerosis: an Update

2017 ◽  
Vol 01 (04) ◽  
pp. E294-E306 ◽  
Author(s):  
Mike Wattjes ◽  
Peter Raab
Keyword(s):  
Multiple Sclerosis ◽  
Quantitative Mri ◽  
Central Vein ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Important Differential Diagnosis ◽  
Magnetic Resonance Imaging Mri ◽  
Near Future ◽  
Brain And Spinal Cord

AbstractMagnetic resonance imaging (MRI) plays an important role in the diagnosis of multiple sclerosis and has been incorporated into the McDonald diagnostic criteria for MS. In particular, for the exclusion of important differential diagnosis and comorbidities, new MRI markers have been established such as the “central vein sign”. In addition to diagnostic purposes, the role of MRI in MS monitoring is becoming increasingly important, particularly for pharmacovigilance. This includes treatment efficacy monitoring, prediction of treatment response and safety monitoring. Quantitative MRI methods and ultra-high-field MRI offer the opportunity for the quantitative assessment of damage in normal-appearing brain tissue. However, the standardization of these techniques with the goal of implementation in clinical routine will be one of the major challenges in the near future.

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