Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis

Neurology ◽  
1998 ◽  
Vol 50 (5) ◽  
pp. 1273-1281 ◽  
Author(s):  
P. S. Sorensen ◽  
B. Wanscher ◽  
C. V. Jensen ◽  
K. Schreiber ◽  
M. Blinkenberg ◽  
...  
1997 ◽  
Vol 3 (2) ◽  
pp. 145-148 ◽  
Author(s):  
P. Soelberg Sørensen ◽  
B. Wanscher ◽  
K. Schreiber ◽  
M. Blinkenberg ◽  
C.V. Jensen ◽  
...  

We enrolled 25 patients with relapsing-remitting or relapsing progressive multiple sclerosis (MS) in a randomized placebo-controlled double-blind study of intravenous immunoglobulin G (IVIG). IVIG Iglkg daily for 2 days was administered every 4 weeks for 24 weeks. Seventeen patients completed the whole trial, whereas eight patients discontinued the trial; four during IVIG treatment and four on placebo. Of the 17 patients who completed the trial, II had no exacerbations during IVIG treatment compared with only six on placebo (P=0.05). The total number of exacerbations in the IVIG period was I / and in the placebo period 15 (NS), and the number of severe exacerbations requiring treatment with intravenous methylprednisolone was four during treatment with IVIG and six on placebo (NS). The results suggest that IVIG treatment may be of beneft for prevention of exacerbations in patients with relapsing MS.


1990 ◽  
Vol 89 (5) ◽  
pp. 554-560 ◽  
Author(s):  
Phillip K. Peterson ◽  
Judy Shepard ◽  
Mark Macres ◽  
Carlos Schenck ◽  
John Crosson ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139828 ◽  
Author(s):  
Willem Jan R. Fokkink ◽  
David Falck ◽  
Tom C. M. Santbergen ◽  
Ruth Huizinga ◽  
Manfred Wuhrer ◽  
...  

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