Multiple thoracic vertebral compression fractures caused by non-accidental injury: case report with radiological?pathological correlation

Multiple myeloma (MM) is a neoplastic disorder characterized by clonal proliferation of malignant plasma cells derived from B cells in bone marrow. Pediatric MM is rare with only approximately 0.3% of cases diagnosed before the age of 30. In this report, we present a 14 years old boy diagnosed as MM with multiple pathologic vertebral fractures. To our knowledge, our patient is the youngest Chinese case in the literature to present with MM. He was treated with bortezomib, dexamethasone, and cyclophosphamide followed by autologous hematopoietic stem cell transplantation with good clinical response. We hope to aid in the understanding of the pathophysiology and management of this condition.

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Kyphoplasty for the Treatment of Vertebral Compression Fractures in a Cancer Patient with Neurological Deficits and Anterior Vertebral Wall Destruction

January 2018 - Pain Physician ◽

10.36076/ppj.2011/14/539 ◽

2011 ◽

Vol 6;14 (6;12) ◽

pp. 539-544

Author(s):

Sang Sik Choi

Keyword(s):

Case Report ◽

Bone Cement ◽

Tumor Metastasis ◽

Balloon Kyphoplasty ◽

Neurological Deficits ◽

Vertebral Compression Fractures ◽

Injection Technique ◽

Lower Extremity Weakness ◽

Compression Fractures ◽

Cement Injection

Background: Percutaneous balloon kyphoplasty is an effective, minimally invasive procedure that is used to relieve pain and stabilize spine fractures caused by severe osteoporosis or osteolysis due to tumor metastasis. However, there remains a risk of bone cement leakage during and after kyphoplasty, especially in cases with severe vertebral wall destruction or neurological deficits. Objective: This article presents a case in which kyphoplasty was used to manage these complications in a woman with vertebral compression fractures caused by tumor metastasis. Design: Case report. Setting: Pain management clinic. Methods: The patient was a 76-year-old woman who had severe low back pain, lower extremity weakness, and cauda equina syndrome because of vertebral compression fracture and spinal metastasis with epidural involvement. The patient had a large bony defect in the vertebra that the bone filler device could pass freely through the anterior body wall. Nevertheless, kyphoplasty was successfully performed by using our new cement injection technique, which is a slow injection of the highly viscous bone cement, followed by a second injection 10 minutes later to allow the previously injected cement to harden. Results: The procedure significantly alleviated all symptoms. The day after the procedure, in the absence of additional pain medication, the pain had dropped dramatically to a numerical rating scale 3-4, and there was an improvement in motor function that allowed the patient to sit and go to the bathroom by herself. In addition, the voiding sensation had returned, which allowed the patient to defecate and urinate normally. Limitations: This report describes a single case report. Conclusion: Our new cement injection technique may allow balloon kyphoplasty to be safely and effectively performed in cancer patients with pathological vertebral compression fractures, even if there are large defects in the anterior vertebral wall and neurological deficits. Key words: Compression fractures, kyphoplasty, metastasis, neurological deficits, osteolysis, polymethylmethacrylate.

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