Management Of Symptomatic De Novo Adult Scoliosis Of The Lumbar Spine Caused By Progressive Hemi-Vertebral Compression Fractures Following Long-Term Glucocorticoid Therapy: A Case Report

10.5580/2613 ◽  
2005 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Case Report ◽  
Lumbar Spine ◽  
De Novo ◽  
Adult Scoliosis ◽  
Glucocorticoid Therapy ◽  
Vertebral Compression Fractures ◽  
Compression Fractures

Bone density and bone health alteration in boys with Duchenne Muscular Dystrophy: a prospective observational study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Renu Suthar ◽  
B. V. Chaithanya Reddy ◽  
Manisha Malviya ◽  
Titiksha Sirari ◽  
Savita Verma Attri ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Health ◽  
Prospective Observational Study ◽  
Bone Fractures ◽  
Long Bone ◽  
Vertebral Compression Fractures ◽  
Serum Osteocalcin ◽  
Z Score ◽  
X Ray ◽  
Compression Fractures

Abstract Objectives Boys with Duchenne Muscular Dystrophy (DMD) are at increased risk for compromised bone health, manifesting as low-impact trauma long bone fractures and vertebral compression fractures. Methods In a prospective observational study, we studied bone health parameters in North Indian boys with DMD. We consecutively enrolled ambulatory boys with DMD on glucocorticoid therapy. Bone health was evaluated with X-ray spine, Dual-energy X-ray absorptiometry (DXA), serum calcium, vitamin D3 (25[OH]D), 1,25-dihyroxyvitamin D3 (1,25[OH]2D3), serum osteocalcin, osteopontin, and N terminal telopeptide of type 1 collagen (Ntx) levels. Results A total of 76 boys with DMD were enrolled. The median age was 8.5 (interquartile range [IQR] 7.04–10.77) years. Among these, seven (9.2%) boys had long bone fractures, and four (5.3%) had vertebral compression fractures. Fifty-four (71%) boys underwent DXA scan, and among these 31 (57%) had low bone mineral density (BMD, ≤−2 z-score) at the lumbar spine. The mean BMD z-score at the lumbar spine was −2.3 (95% confidence interval [CI] = −1.8, −2.8), and at the femoral neck was −2.5 (95% CI = −2, −2.9). 25(OH)D levels were deficient in 68 (89.5%, n=76) boys, and 1,25(OH)2D3 levels were deficient in all. Mean serum osteocalcin levels were 0.68 ± 0.38 ng/mL (n=54), serum osteopontin levels were 8.6 ± 4.6 pg/mL (n=54) and serum Ntx levels were 891 ± 476 nmol/L (n=54). Boys with low BMD received glucocorticoids for longer duration, in comparison to those with normal BMD (median, IQR [16.9 (6–34) months vs. 7.8 (4.8–13.4) months]; p=0.04). Conclusions Bone health is compromised in North Indian boys with DMD. BMD at the lumbar spine is reduced in more than half of boys with DMD and nearly all had vitamin D deficiency on regular vitamin D supplements. Longer duration of glucocorticoid therapy is a risk factor for low BMD in our cohort.

Poster 326: Multilevel Vertebral Compression Fractures Due to Pregnancy Induced Osteoporosis and Lovenox Use in a Post-Partum Patient: A Case Report

PM&R ◽  
2018 ◽  
Vol 10 ◽  
pp. S108-S108
Author(s):  
John A. Wallington ◽  
Lisa Grant ◽  
Christine C. Chamberlain
Keyword(s):  
Case Report ◽  
Post Partum ◽  
Vertebral Compression Fractures ◽  
Compression Fractures

scholarly journals De novo appearance of intracranial Rosai-Dorfman disease during long-term follow-up: A case report

2020 ◽  
Vol 22 ◽  
pp. 100891
Author(s):  
Nobuhiro Nakagawa ◽  
Norihito Fukawa ◽  
Kiyoshi Tsuji ◽  
Naoki Nakano ◽  
Amami Kato
Keyword(s):  
Case Report ◽  
De Novo ◽  
Rosai Dorfman Disease ◽  
Long Term Follow Up

scholarly journals Analysis of two minimally invasive procedures for osteoporotic vertebral compression fractures with intravertebral cleft: a systematic review and meta-analysis

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hongyu Wei ◽  
Chunke Dong ◽  
Yuting Zhu ◽  
Haoning Ma
Keyword(s):  
Meta Analysis ◽  
Operation Time ◽  
Cement Leakage ◽  
Vertebral Compression Fractures ◽  
Controlled Trials ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Vertebral Height ◽  
Compression Fractures ◽  
Short And Long Term

Abstract Background A systematic review and meta-analysis to assess the pros and cons of percutaneous vertebroplasty (PVP) versus kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) with intravertebral cleft (IVC) including all available evidence from controlled trials. Methods Databases including Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched to identify relevant studies comparing PVP and PKP for OVCFs with IVC. The outcomes mainly included visual analog scale (VAS), Oswestry Disability Index (ODI), local kyphotic angle (LKA), rate of vertebral height (VH%), and adverse events. Results Nine studies enrolling 688 patients were eligible for meta-analysis. The results indicated no significant differences between the two groups in the short-and long-term VAS, ODI, LKA, or VH% (P > 0.05). Compared with PVP, PKP was associated with significantly longer operation time (P < 0.05), higher cost (P > 0.05), and more injected cement volume (P < 0.05). In terms of adverse events, PKP has a lower risk of cement leakage (P < 0.05), while with no significant difference in adjacent-level fracture rates (P > 0.05). Conclusion The two procedures have similar short- and long-term pain relief, functional recovery, local kyphosis correction, and vertebral height maintenance in OVCFs with IVC. PKP is superior to PVP for the injected cement volume, and lower cement leakage rate, however, with longer operation time, more fluoroscopy times, and higher cost. Further randomized controlled trials (RCTs) should be conducted to confirm these results.

scholarly journals Refractory De Novo Multiple Cerebral Aneurysms After Radiotherapy and Multistaged “Open” Surgical Treatment for Low-Grade Glioma During Long-Term Follow-Up: A Case Report and Review of the Literature

2019 ◽  
Vol 3 ◽  
pp. 100031 ◽  
Author(s):  
Fumiaki Maruyama ◽  
Toshihide Tanaka ◽  
Ikki Kajiwara ◽  
Koreaki Irie ◽  
Toshihiro Ishibashi ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
De Novo ◽  
Cerebral Aneurysms ◽  
Low Grade ◽  
Review Of The Literature ◽  
Long Term Follow Up ◽  
Open Surgical Treatment

Preoperative chemoradiotherapy for pancreatic cancer encountered vertebral compression fractures.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 227-227
Author(s):  
Keisuke Otani ◽  
Teruki Teshima ◽  
Kinji Nishiyama ◽  
Yuri Ito ◽  
Yoshifumi Kawaguchi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
De Novo ◽  
Preoperative Chemoradiotherapy ◽  
Incidence Rates ◽  
Mesenteric Arteries ◽  
Vertebral Compression Fractures ◽  
Resectable Pancreatic Cancer ◽  
Compression Fractures ◽  
Dose Volume ◽  
Vertebral Bodies

227 Background: Preoperative chemoradiotherapy (CRT) with gemcitabine (GEM) for pancreatic cancer at our institute achieved excellent cure rates, while treated patients encountered vertebral compression fractures (VCFs) frequently. Methods: From January 2006 to December 2011, 220 patients (male/female: 134/86, median age: 66 (range: 33-84)) with resectable pancreatic cancer have been treated with preoperative CRT with GEM. This method consisted of concurrent radiotherapy (50-60 Gy in 25 fractions over 5 weeks) and chemotherapy (GEM 1,000 mg/m2intravenous, weekly for 12-15 weeks, 3 times during 4 weeks). Three-dimensional conformal radiotherapy was used and its fields covered both primary pancreatic tumor and retropancreatic tissues with 50 Gy level. Boost irradiation to the roots of celiac and superior mesenteric arteries with 2.4 Gy/fr using field-within-field technique has been started since 2009. The risk factors for VCF and its causes were retrospectively analyzed for 1,308 Th10-L3 vertebral bodies. Results: Follow-up time from the initiation of CRT ranged from 3.4-73.9 months (median: 17.9). Median overall survival time of these patients was 40.6 months. Radical surgery was completed in 164 patients (75%). Twenty-five patients (11%) diagnosed as VCF (CTCAE v4.0 grade1/2: 12/13) and 22 of them were at 3.6-23 months from CRT. Cumulative incidence rates at 2 years were 18.9% in total, 8.5% in male and 38.4% in female (p = 0.0002). Corresponding rates were 5.1% in age < 60 and 24.9% in age ≥ 60 (p = 0.0107). On their courses 37 de novo VCFs (Th10/11/12/L1/2/3: 2/3/11/13/7/1) were observed at first and 9 patients repeated VCFs near the initial VCFs. Dose-volume factors of each vertebral bodies also significantly correlated with VCF; vertebrae whose mean dose were < 38 Gy/ ≥ 38 Gy developed VCFs in 2.7%/10.0% at 2 years (p < 0.0001), vertebrae whose V30 were < 80%/≥80% developed VCFs in 2.4%/10.6% (p < 0.0001). Conclusions: Besides women and higher age, dose-volume factors of radiotherapy were risk of developing VCF in patients with pancreatic cancer after preoperative CRT with GEM. These findings should be considered to avoid VCFs as late adverse event after CRT for pancreatic cancer, especially in IMRT era.

scholarly journals Long-term skeletal consequences of childhood acute lymphoblastic leukemia in adult males: a cohort study

2013 ◽  
Vol 168 (2) ◽  
pp. 281-288 ◽  
Author(s):  
O Mäkitie ◽  
R Heikkinen ◽  
S Toiviainen-Salo ◽  
M Henriksson ◽  
L-R Puukko-Viertomies ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Lumbar Spine ◽  
Lymphoblastic Leukemia ◽  
Whole Body ◽  
Compression Fractures ◽  
Lower Lumbar Spine ◽  
Spinal Compression ◽  
Lower Lumbar

ObjectiveLong-term health sequelae of childhood-onset acute lymphoblastic leukemia (ALL) remain largely unknown. Low bone mineral content (BMC) and bone mineral density (BMD) are recognized complications, but it is unknown whether these persist until adulthood. We evaluated skeletal characteristics and their association with ALL therapy in long-term male ALL survivors.DesignThis cross-sectional cohort study included 49 long-term male ALL survivors and 55 age-matched healthy males.MethodsBMD and compression fractures were assessed by dual-energy X-ray absorptiometry; blood biochemistry was obtained for parameters of calcium homeostasis.ResultsThe ALL survivors (median age 29 years, range 25–38 years), assessed 10–38 years after ALL diagnosis, had lower lumbar spine (P<0.001), femoral neck (P<0.001), and whole-body (P=0.017) BMD than expected based on normative values. When compared with the controls (median age 30 years, range 24–36 years), the ALL survivors had lower lumbar spine BMC (P=0.014), lower whole-body BMC (P<0.001), and lower whole-body BMD (P<0.001), but the differences were partly explained by differences in height. Altogether, 20% of the ALL survivors had spinal compression fractures, but these were equally prevalent in the controls. Males diagnosed with ALL before age 5 years had significantly lower BMD values. Other recognized risk factors included untreated hypogonadism, vitamin D deficiency, hypophosphatemia, low IGF-binding protein-3, and low physical activity.ConclusionsAt young adulthood, long-term male ALL survivors have significantly reduced BMC and BMD and a high prevalence of spinal compression fractures. Careful follow-up and active treatment of the recognized risk factors are warranted.

scholarly journals Case Report: Multiple Vertebral Compression Fractures in 14-Year-Old Children With Multiple Myeloma

2021 ◽  
Vol 11 ◽  
Author(s):  
Xia Wang ◽  
He He ◽  
Mei Zhang ◽  
Chuan Li ◽  
Chengyao Jia
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Case Report ◽  
Plasma Cells ◽  
Vertebral Compression Fractures ◽  
Good Clinical Response ◽  
Hematopoietic Stem ◽  
Compression Fractures ◽  
Clonal Proliferation ◽  
Chinese Case

Multiple myeloma (MM) is a neoplastic disorder characterized by clonal proliferation of malignant plasma cells derived from B cells in bone marrow. Pediatric MM is rare with only approximately 0.3% of cases diagnosed before the age of 30. In this report, we present a 14 years old boy diagnosed as MM with multiple pathologic vertebral fractures. To our knowledge, our patient is the youngest Chinese case in the literature to present with MM. He was treated with bortezomib, dexamethasone, and cyclophosphamide followed by autologous hematopoietic stem cell transplantation with good clinical response. We hope to aid in the understanding of the pathophysiology and management of this condition.

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