A live attenuated BCG vaccine overexpressing multistage antigens Ag85B and HspX provides superior protection against Mycobacterium tuberculosis infection

2015 ◽  
Vol 99 (24) ◽  
pp. 10587-10595 ◽  
Author(s):  
Xuefeng Yuan ◽  
Xindong Teng ◽  
Yukai Jing ◽  
Jilei Ma ◽  
Maopeng Tian ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

The Ag85B protein of the BCG vaccine facilitates macrophage uptake but is dispensable for protection against aerosol Mycobacterium tuberculosis infection

Vaccine ◽  
2016 ◽  
Vol 34 (23) ◽  
pp. 2608-2615 ◽  
Author(s):  
Kelly A. Prendergast ◽  
Claudio Counoupas ◽  
Lisa Leotta ◽  
Carolina Eto ◽  
Wilbert Bitter ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Macrophage Uptake

BCG Vaccine Protection Against Mycobacterium tuberculosis Infection by Level of Exposure in The Gambia

2020 ◽  
Author(s):  
Nicola Campbell ◽  
Ayesha J Verrall ◽  
Simon Donkor ◽  
Jayne S Sutherland ◽  
Philip C Hill
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Relative Risk ◽  
Confidence Interval ◽  
Poisson Regression ◽  
The Gambia ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Vaccine Protection ◽  
Pathogen Exposure

Abstract In Indonesia, BCG vaccine protection against Mycobacterium tuberculosis infection decreased with increasing exposure to the pathogen. We aimed to validate these findings in Africa. Poisson regression was used to estimate BCG protection, stratified by pathogen exposure using an exposure score, against enzyme-linked immunospot assay conversion at 3 months in 220 Gambian case contacts. Although the interaction between BCG and exposure was not significant (P = .13), BCG protection was strongest in the lowest-exposure tertile (relative risk, 0.35 [95% confidence interval, .15–.82; P = .02] vs 0.50 [.30–.83; P = .008] and 0.71 (.45–1.13; P = .1] for the middle and highest-exposure tertiles, respectively. These results are consistent with those from Indonesia.

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