Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice

Vaccine ◽  
2011 ◽  
Vol 29 (29-30) ◽  
pp. 4754-4760 ◽  
Author(s):  
Vipul K. Singh ◽  
Vikas Srivastava ◽  
Vinayak Singh ◽  
Neeraj Rastogi ◽  
Raja Roy ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Mycobacterium Bovis Bcg

scholarly journals Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination

2014 ◽  
Vol 21 (4) ◽  
pp. 594-597 ◽  
Author(s):  
Nacho Aguilo ◽  
Ana Maria Toledo ◽  
Eva Maria Lopez-Roman ◽  
Esther Perez-Herran ◽  
Eamonn Gormley ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Mycobacterium Bovis ◽  
Dose Range ◽  
Bcg Vaccine ◽  
Content Type ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Dose Dependent

ABSTRACTWorldwide, theMycobacterium bovisBCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection againstMycobacterium tuberculosischallenge compared to that of subcutaneous vaccination.

The Ag85B protein of the BCG vaccine facilitates macrophage uptake but is dispensable for protection against aerosol Mycobacterium tuberculosis infection

Vaccine ◽  
2016 ◽  
Vol 34 (23) ◽  
pp. 2608-2615 ◽  
Author(s):  
Kelly A. Prendergast ◽  
Claudio Counoupas ◽  
Lisa Leotta ◽  
Carolina Eto ◽  
Wilbert Bitter ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Macrophage Uptake

BCG Vaccine Protection Against Mycobacterium tuberculosis Infection by Level of Exposure in The Gambia

2020 ◽  
Author(s):  
Nicola Campbell ◽  
Ayesha J Verrall ◽  
Simon Donkor ◽  
Jayne S Sutherland ◽  
Philip C Hill
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Relative Risk ◽  
Confidence Interval ◽  
Poisson Regression ◽  
The Gambia ◽  
Bcg Vaccine ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Vaccine Protection ◽  
Pathogen Exposure

Abstract In Indonesia, BCG vaccine protection against Mycobacterium tuberculosis infection decreased with increasing exposure to the pathogen. We aimed to validate these findings in Africa. Poisson regression was used to estimate BCG protection, stratified by pathogen exposure using an exposure score, against enzyme-linked immunospot assay conversion at 3 months in 220 Gambian case contacts. Although the interaction between BCG and exposure was not significant (P = .13), BCG protection was strongest in the lowest-exposure tertile (relative risk, 0.35 [95% confidence interval, .15–.82; P = .02] vs 0.50 [.30–.83; P = .008] and 0.71 (.45–1.13; P = .1] for the middle and highest-exposure tertiles, respectively. These results are consistent with those from Indonesia.

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