Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia

2001 ◽  
Vol 30 (2) ◽  
pp. 99-103 ◽  
Author(s):  
A. Ogose ◽  
Tetsuo Hotta ◽  
Iwao Emura ◽  
Hiroshi Hatano ◽  
Yoshiya Inoue ◽  
...  
Keyword(s):  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

scholarly journals Oncogenic Osteomalacia Associated with Phosphaturic Mesenchymal Tumor of the Knee: Case Presentation and Review of the Literature

2013 ◽  
Vol 04 (07) ◽  
pp. 24-27
Author(s):  
Eugenio Vecchini ◽  
Tommaso Maluta ◽  
Manuel Bondi ◽  
Francesco Perusi ◽  
Stefano Dall’Oglio ◽  
...  
Keyword(s):  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Review Of The Literature ◽  
Oncogenic Osteomalacia ◽  
Case Presentation

scholarly journals Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the femur: A case report

2019 ◽  
Vol 7 (15) ◽  
pp. 2081-2086
Author(s):  
Dong Tang ◽  
Xiao-Man Wang ◽  
Yong-Sheng Zhang ◽  
Xiao-Xiao Mi
Keyword(s):  
Case Report ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

scholarly journals Fibroblast Growth Factor 23-Producing Phosphaturic Mesenchymal Tumor with Extraordinary Morphology Causing Oncogenic Osteomalacia

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 34
Author(s):  
Cornelia Then ◽  
Evelyn Asbach ◽  
Harald Bartsch ◽  
Niklas Thon ◽  
Christian Betz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Olfactory Neuroblastoma ◽  
Mesenchymal Tumor ◽  
Fibroblast Growth ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia ◽  
Pet Ct ◽  
Fgf 23

A possible cause of hypophosphatemia is paraneoplastic secretion of fibroblast growth factor 23 (FGF-23). Tumors secreting FGF-23 are rare, mostly of mesenchymal origin, usually benign, and may be located anywhere in the body, including hands and feet, which are often not represented in conventional imaging. A 50-year-old woman presented with diffuse musculoskeletal pain and several fractures. Secondary causes of osteoporosis were excluded. Laboratory analysis revealed hypophosphatemia and elevated alkaline phosphatase, parathyroid hormone, and FGF-23. Thus, oncogenic osteomalacia due to neoplastic FGF-23 secretion was suspected. FDG-PET-CT and DOTATATE-PET-CT imaging demonstrated no tumor. Cranial MRI revealed a tumorous mass in the left cellulae ethmoidales. The tumor was resected and histopathological examination showed a cell-rich tumor with round to ovoid nuclei, sparse cytoplasm, and sparse matrix, resembling an olfactory neuroblastoma. Immunohistochemical analysis first led to diagnosis of olfactory neuroblastoma, which was later revised to phosphaturic mesenchymal tumor. Following the resection, FGF-23 and phosphate levels normalized. In conclusion, we here describe a patient with an FGF-23-secreting phosphaturic mesenchymal tumor with an unusual morphology. Furthermore, we emphasize diagnostic pitfalls when dealing with FGF-23-induced hypophosphatemia.

Oncogenic osteomalacia secondary to phosphaturic mesenchymal tumor of the foot

2020 ◽  
Vol 27 (3) ◽  
pp. 210-214
Author(s):  
Sandra Garrote-Corral ◽  
Walter Alberto Sifuentes-Giraldo ◽  
María Eugenia Reguero-Callejas ◽  
Mónica Vázquez-Díaz
Keyword(s):  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

Oncogenic Osteomalacia Caused by a Phosphaturic Mesenchymal Tumor of the Mandible: a Case Report

2018 ◽  
Vol 126 (4) ◽  
pp. e199
Author(s):  
Rishabh P. Acharya ◽  
Alexander M. Won ◽  
Amy C. Hessel ◽  
Mark S. Chambers ◽  
Robert F. Gagel
Keyword(s):  
Case Report ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

Oncogenic Osteomalacia Caused by Phosphaturic Mesenchymal Tumor of the Temporal Bone

2006 ◽  
Vol 135 (4) ◽  
pp. 653-654 ◽  
Author(s):  
David M. Kaylie ◽  
C. Gary Jackson ◽  
Edward K. Gardner
Keyword(s):  
Temporal Bone ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

scholarly journals Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia

2012 ◽  
Vol 3 (1) ◽  
pp. 151 ◽  
Author(s):  
ReginaS Bower ◽  
WilsonP Daugherty ◽  
Caterina Giannini ◽  
IanF Parney
Keyword(s):  
Connective Tissue ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

Phosphaturic mesenchymal tumor of the tibia with oncogenic osteomalacia in a teenager

2015 ◽  
Vol 45 (9) ◽  
pp. 1423-1426 ◽  
Author(s):  
Shannon G. Farmakis ◽  
Marilyn J. Siegel
Keyword(s):  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia

Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine

2009 ◽  
Vol 10 (4) ◽  
pp. 329-333 ◽  
Author(s):  
Elena Pirola ◽  
Francesco Vergani ◽  
Paolo Casiraghi ◽  
Eugenio Biagio Leone ◽  
Paolo Guerra ◽  
...  
Keyword(s):  
Thoracic Spine ◽  
Paraneoplastic Syndrome ◽  
Tumor Resection ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia ◽  
Mesenchymal Tumors ◽  
History Of ◽  
Complete Tumor

Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare. The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level. Complete tumor resection was accomplished. The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant). After lesion removal, the paraneoplastic syndrome resolved. At the 24-month follow-up, no recurrence of the disease was observed. The clinical presentation, surgical technique, and follow-up in this case were reviewed in detail.

Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor

1996 ◽  
Vol 84 (2) ◽  
pp. 288-292 ◽  
Author(s):  
Karoly David ◽  
Tamas Revesz ◽  
George Kratimenos ◽  
Thomas Krausz ◽  
H. Alan Crockard
Keyword(s):  
Ct Scan ◽  
Symptomatic Relief ◽  
Symptomatic Improvement ◽  
Mesenchymal Tumor ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia ◽  
Content Type ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

✓ A 60-year-old woman suffered from hypophosphatemic osteomalacia secondary to a frontal intracranial tumor. Oral administration of phosphate and 1-α-hydroxyvitamin D3 provided only temporary symptomatic relief. A computerized tomography (CT) scan of the patient's head revealed a large subfrontal tumor attached to the dura. Following removal of the tumor, the patient's hypophosphatemia subsided; her level of 1,25-dihydroxyvitamin D3, which was undetectable preoperatively, returned to normal, and she had symptomatic improvement. Three years later, decreasing levels of phosphate and 1,25-dihydroxyvitamin D3 indicated tumor recurrence, before it was detected by CT scan. Histological examination of the tumor provided the diagnosis of “mixed connective tissue variant of phosphaturic mesenchymal tumor.” The characteristic histological features of this relatively rare entity are discussed. This is the first report of a surgically treated intracranial phosphaturic mesenchymal tumor that caused oncogenic osteomalacia.

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