Mesenchymal Tumor
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2021 ◽  
Vol 12 (2) ◽  
pp. 598-602
Zenab Alami ◽  
Amina Bouziane ◽  
Wissal Hassani ◽  
Fatima Zahrae Farhane ◽  
Touria Bouhafa

Paratesticular Rhabdomyosarcoma is a rare mesenchymal tumor. The Alveolar variant is the one with the worse prognosis. It comprehend 20% of cases. The treatment is multimodal combining surgery, chemotherapy and radiotherapy. Depending on the extent of disease and the staging group, the approach of treatment is different. Here we report the case of an alveolar Paratesticular rhabdomyosarcoma and review the literature regarding this unusual clinical entity.

2021 ◽  
Jiahan Liu ◽  
Rongjun Mao ◽  
I Weng Lao ◽  
Lin Yu ◽  
Qianming Bai ◽  

2021 ◽  
Josiah Sowell ◽  
Siddharth Srikakolapu ◽  
Ana Preda-Naumescu ◽  
Om Patel ◽  
Meredith Thomley ◽  

Ekta Dhamija ◽  
Harshal Aswar ◽  
Sawyer Ehmad ◽  
Adarsh Barwad ◽  
Rambha Pandey ◽  

Abstract Background Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor predominantly affecting the pelvis and perineum of females. Due to its variable clinical presentation, it is often misinterpreted and treated as other pathologies like Bartholin gland cyst, vulvar abscess, and hernia. The tumor is locally infiltrative, making its complete surgical removal difficult. Aim The aim of the study is to highlight and illustrate the imaging and pathological features of AAM. Materials and Methods After obtaining clearance from the Institutional Ethics Committee, a retrospective study was conducted on patients with histopathological diagnosis of AAM, presenting to the dedicated sarcoma clinic between 2016 and 2019. The demographic, clinical, radiological, pathological, and treatment details were obtained from the institute's database. The magnetic resonance imaging (MRI) and computed tomography images were reviewed to assess different imaging parameters. Follow-up imaging was assessed for residual or recurrent mass in the pelvis or perineum and distant metastasis. Results A total of four patients were included with an age range of 28 to 50 years. The baseline MRI of these four patients shows pelvic mass extending into the perineum, infiltrating along the surrounding fascial planes with the characteristic laminated appearance on T2-weighted image and gradual intense enhancement following contrast administration. All patients had residual disease post-surgery and were put on hormonal therapy. Conclusion AAMs are locally aggressive, rarely metastasizing mesenchymal tumor that has a specific predilection for the perineum and pelvis of females. MRI features like laminated or striated appearance, post-contrast enhancement, and finger-like infiltrating projections should raise the suspicion of the diagnosis on baseline imaging.

2021 ◽  
Qian Cui ◽  
Hongmei Wu ◽  
Yu Chen ◽  
Zebin Xiao ◽  
Jie Chen ◽  

Abstract Background:Genomic rearrangements involving EWSR1 and the CREB family of transcription factors are increasingly detected in an array of mesenchymal neoplasms, including clear cell sarcoma-like tumors of the gastrointestinal tract (CCSLGT), a gastrointestinal malignancy. Gastritis cystica profunda (GCP) is a rare disease characterized by cystic dilatation of gastric glands into the submucosa and generally regarded as a precursor to tumor.Case presentation:Herein, we report a peculiar case in which a EWSR1-CREM-rearranged gastric mesenchymal tumor was admixed with GCP in a gastric fundic mass in a 64-year-old woman. Histologically, the mass showed readily distinguishable epithelial and mesenchymal components. All layers of the gastric wall were invaded, although no lymph node or neural invasion, or tumoral vascular emboli was noted. The epithelial component consisted of foveolar-type glands interspersed with pyloric-type ones, with glands showing metaplastic growth. Most glands were elongated with irregular contour, with some forming cystic structures containing eosinophilic secretory material. The epithelial cells showed focally atypical hyperchromatic nuclei, inconspicuous nucleoli, slightly eosinophilic cytoplasm, and infrequent mitosis. The mesenchymal component consisted of monomorphic, ovoid-shaped cells often arranged in sheets surrounding the glands. These cells displayed scanty cytoplasm, regular nuclei, and rare mitotic figures. Immunohistochemically, the epithelial cells were uniformly positive for cytokeratins and negative for markers of neuroendocrine differentiation, and the mesenchymal neoplasm showed focal positivity for CD10, CD117 and CD56 as well as negativity for cytokeratin, neuroendocrine markers, DOG-1, CD34, SMA, desmin, HMB-45, Melan A, and S-100. An EWSR1-CREM fusion was identified with genomic profiling and confirmed with fluorescence in situ hybridization in the tumor. Given the low mitotic activity, absence of nodal or distant spread and vascular or neural invasion, and the disease-free status at 28-month follow-up, both lesions were likely benign. Conclusions:To our knowledge, this is the first to report a EWSR1-CREM fusion in a gastric mesenchymal tumor with accompanying GCP. Whether this case suggests a novel entity or falls into one of proposed classes awaits report of more similar cases and insights into the relationship between GCP pathogenesis and oncogenesis.

2021 ◽  
Vol 79 (10) ◽  
pp. e93-e94
M.A. Khan ◽  
K. Maharaj ◽  
C. Burns ◽  
M. Cameron

2021 ◽  
Vol 9 (09) ◽  
pp. 262-265
R. Ait Ouali ◽  
M. Aarab ◽  
L. Sidi Abdella ◽  
MA. Lakmichi ◽  

Introduction: The leiomyoma of the urethra is rare. It is a benign mesenchymal tumor that affects the smooth muscle of the urethra. These tumors often occur in women of childbearing age the middle age of their appearance is about 41 years old. Case report: Here we report the case of a 37 years old white woman with progressive dysuria with nodule sensation in the vagina Conclusions: Leiomyoma is a benign tumor, common in the uterus but very rare in the urethra. His diagnosis is rarely mentioned. The para-clinical assessment specifies the characteristics, the reports of the tumor, and directs on its nature. Open or endoscopic surgical excision allows both the diagnosis and the treatment of symptoms.

Medicine ◽  
2021 ◽  
Vol 100 (38) ◽  
pp. e27284
Taiki Takaoka ◽  
Natsuo Tomita ◽  
Yoji Shido ◽  
Satoshi Baba ◽  
Mayu Fukushima ◽  

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