A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery

2020 ◽  
Vol 44 (8) ◽  
pp. 2656-2666
Author(s):  
Jing Wen Loh ◽  
Nur Aishah Taib ◽  
Yew Teik Cheong ◽  
Tin Su Tin
Keyword(s):  
Randomized Controlled Trial ◽  
Pain Relief ◽  
Controlled Trial ◽  
Parathyroid Surgery ◽  
Wound Infiltration ◽  
Double Blind ◽  
Randomized Controlled ◽  
Post Operative Pain ◽  
Incision Wound

Does lidocaine as an adjuvant to morphine improve pain relief in patients presenting to the ED with acute renal colic? A double-blind, randomized controlled trial

2016 ◽  
Vol 34 (3) ◽  
pp. 443-448 ◽  
Author(s):  
Abolfazl Firouzian ◽  
Abbas Alipour ◽  
Hale Rashidian Dezfouli ◽  
Alieh Zamani Kiasari ◽  
Afshin Gholipour Baradari ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pain Relief ◽  
Renal Colic ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled ◽  
Acute Renal Colic

A prospective double-blind randomized controlled trial of the effect of topical bupivacaine on post-operative pain in bilateral nasal surgery with bilateral nasal packs inserted

2005 ◽  
Vol 119 (4) ◽  
pp. 284-288 ◽  
Author(s):  
Malcolm A Buchanan ◽  
Graham R Dunn ◽  
Gillian M MacDougall
Keyword(s):  
Randomized Controlled Trial ◽  
Local Anaesthetic ◽  
Controlled Trial ◽  
Nasal Surgery ◽  
Double Blind ◽  
Control Power ◽  
Randomized Controlled ◽  
Post Operative Pain ◽  
Number Of Patients ◽  
Significant Difference

To ascertain whether local anaesthetic use is of clinical benefit in nasal surgery, a prospective double-blind randomized controlled trial of topical bupivacaine on post-operative pain in patients packed after bilateral nasal surgery was carried out. Each patient received a bupivacaine-soaked and a saline-soaked Merocel pack, thereby acting as their own control. Power analysis ascertained the number of patients required to enter the trial to detect a statistically significant difference in pain. Fifty-seven patients completed the trial. Visual analogue scales determined the level of post-operative pain at different time points in each nostril. Less pain was demonstrated in nostrils containing bupivacaine-soaked packs compared with saline-soaked packs at two hours (p < 0.0001), four hours (p = 0.0183) and six hours (p = 0.0476) post-operatively. Although not statistically significant, less pain was noted on pack removal on the local anaesthetic sides. These results provide clinical-based evidence for the use of bupivacaine as a local anaesthetic in reducing pain following nasal surgery with packing.

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