scholarly journals The anemia-independent impact of myelodysplastic syndromes on health-related quality of life

2021 ◽  
Author(s):  
Hanneke J. C. M. Wouters ◽  
Annette Conrads-Frank ◽  
Karin A. Koinig ◽  
Alex Smith ◽  
Ge Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Myelodysplastic Syndromes ◽  
Lower Risk ◽  
Large Population ◽  
Index Score ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

AbstractMyelodysplastic syndromes (MDS) are in the majority of cases characterized by anemia. Both anemia and MDS per se may directly contribute to impairments in health-related quality of life (HRQoL). In this study, we aimed to investigate the anemia-independent impact of MDS on HRQoL. We evaluated participants (≥ 50 years) from the large population-based Lifelines cohort (N = 44,694, mean age 59.0 ± 7.4 years, 43.6% male) and the European MDS Registry (EUMDS) (N = 1538, mean age 73.4 ± 9.0 years, 63.0% male), which comprises a cohort of lower-risk MDS patients. To enable comparison concerning HRQoL, SF-36 scores measured in Lifelines were converted to EQ-5D-3L index (range 0–1) and dimension scores. Lower-risk MDS patients had significantly lower HRQoL than those from the Lifelines cohort, as illustrated in both the index score and in the five different dimensions. Multivariable linear regression analysis demonstrated that MDS had an adjusted total impact on the EQ-5D index score (B =  − 0.12, p < 0.001) and an anemia-independent “direct” impact (B =  − 0.10, p < 0.001). Multivariable logistic regression analysis revealed an anemia-independent impact of MDS in the dimension mobility, self-care, usual activities, and anxiety/depression (all except pain/discomfort). This study demonstrates that the major part of the negative impact of lower-risk MDS on HRQoL is not mediated via anemia. Thus, the therapeutic focus should include treatment strategies directed at underlying pathogenic mechanisms to improve HRQoL, rather than aiming predominantly at increasing hemoglobin levels.

scholarly journals The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study

2018 ◽  
Vol 18 (2) ◽  
pp. 136-144.e7 ◽  
Author(s):  
Valeria Santini ◽  
Antonio Almeida ◽  
Aristoteles Giagounidis ◽  
Uwe Platzbecker ◽  
Rena Buckstein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myelodysplastic Syndromes ◽  
Lower Risk ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Health-related quality of life 1–3 years post-myocardial infarction: its impact on prognosis

Open Heart ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. e001499
Author(s):  
Stuart Pocock ◽  
David B Brieger ◽  
Ruth Owen ◽  
Jiyan Chen ◽  
Mauricio G Cohen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Resource Use ◽  
Rate Ratio ◽  
Index Score ◽  
Health Related Quality ◽  
Lower Index ◽  
Related Quality ◽  
Health Related

ObjectiveTo assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).MethodsThe global, prospective, observational TIGRIS Study enrolled 9126 patients 1–3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years’ follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years’ follow-up.ResultsAmong 8978 patients who completed the EQ-5D questionnaire, 52% reported ‘some’ or ‘severe’ problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years’ follow-up.ConclusionsClinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death.Trial registration numberClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).

Determinants of health-related quality of life in colon cancer patients include stoma and smoking habits, but not type of surgery

2019 ◽  
Author(s):  
Catarina Tiselius ◽  
Andreas Rosenblad ◽  
Eva Strand ◽  
Kennet Smedh
Keyword(s):  
Quality Of Life ◽  
Colon Cancer ◽  
Regression Analysis ◽  
Cancer Patients ◽  
Linear Regression Analysis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background: Health-related quality of life (HRQoL) has gained increased attention in cancer care. Studies have shown that poor QoL might worsen the cancer related prognosis. The aim of this study was to investigate HRQoL in patients with colon cancer and to compare data with reference values from the general population in Sweden at diagnosis (baseline) and at six months of follow-up. Methods : This was a prospective population-based study of colon cancer patients from Västmanland County, Sweden, included between March 2012 and September 2016. HRQoL was measured using the cancer-specific EORTC QLQ-C30 questionnaire. Data on HRQoL was compared with Swedish population reference values. Multiple linear regression analysis adjusted for age, sex, body mass index (BMI), American Society of Anaesthesiology (ASA) physical status classification, emergency/elective surgery, and resection with/without a stoma and tumour stage (TNM), was used. Results : A total of 67% (376/561) of all incident colon cancer patients (196 [52.1%] females) were included. Mean (range) age was 73 (30-96) years. The univariate analysis showed that patients with colon cancer had worse QoL (8/15 parameters) compared with a Swedish reference population both at baseline and at 6 months follow-up. Furthermore, linear regression analysis showed that patients with more comorbidity (ASA 3 and 4), smokers and patients planned to be operated on with a stoma, were at higher risks for poor QoL than the other included patients. Conclusions : The reported determinants of HRQoL may be used to identify risk groups and enable individualized care for patients that need more support from health care.

Multiple Regression Analysis of Factors Affecting Health-Related Quality of Life in Adult Spinal Deformity

2015 ◽  
Vol 3 (4) ◽  
pp. 360-366 ◽  
Author(s):  
Emre Acaroglu ◽  
Umit O. Guler ◽  
Z. Deniz Olgun ◽  
Yalcin Yavuz ◽  
Ferran Pellise ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Spinal Deformity ◽  
Adult Spinal Deformity ◽  
Health Related Quality ◽  
Factors Affecting ◽  
Related Quality ◽  
Health Related

scholarly journals Impact of Tenofovir/Lamivudine/Dolutegravir (Tld) on the Health-Related Quality of Life and Clinical Outcomes of HIV/AIDS Patients at a Tertiary Health Facility in Niger State

2020 ◽  
Author(s):  
Danjuma Umar ◽  
Bala Waziri ◽  
Umar Ndagi ◽  
Shafiu Mohammed ◽  
Ndagi Usman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Viral Load ◽  
Clinical Outcomes ◽  
Viral Suppression ◽  
Baseline Viral Load ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background: Human Immuno-deficiency Virus (HIV) remains a major global public health issue. However, it is now considered a chronic infection which can be managed with new, well-tolerated and efficacious ARVs. The aim of the study was to evaluate the effect of Tenofovir/Lamivudine/Dolutrgravir (TLD) on the HRQoL and viral suppression over a short period.Method: The study was prospective, with a time frame of three (3) months. HRQoL was measured using a disease specific HIV/AID Targeted Quality of Life (HAT-QoL) tool and the clinical outcomes focused on viral load using structured data collection tool.Results: Most of the participants were female (62.1%), currently married 63.2% and no co-morbidity, mean age 43±SD (range 21-77years). There was a statistically significant improvement in HRQoL scores across all domain after 3months of transitioning to TLD. While 8 of the 9 domains namely; overall functions, life satisfaction, health worries, financial worries, medication worries, HIV mastery, Disclosure worries, Provider trust, (p <0.001) sexual function (p =0.015). Improvement was also seen in viral suppression (p <0.001).Using multiple linear regression analysis, predictors for overall HRQol scores include female gender (ᵝ= 3.59, 95%CI 1.30-5.78, p=0.002), older age, >65years (ᵝ= 4.12, 95%CI -1.42,9.67 p=0.08), living with family (ᵝ= -5.80, 95%CI -9.60,-2.00, p=0.003), higher family income, >N100,000 (ᵝ= 6.09, 95%CI 1.75,10.44, p=0.006) and duration on ART (ᵝ=0.52, 95%CI 0.12, 0.91, p=0.01). While determinants of viral suppression using multi-variant logistic regression analysis revealed living with family (AOR=18.03, 95%CI 3.32-97.85, p<0.001), Primary education (AOR= 0.16, 965%CI 0.029,0.93, P=0.041), being employed (AOR=0.16, 95%CI 0.028,0.91, P=0.008), income and baseline viral load (AOR= 0.53, 95%CI 0.44,0.69, p<0.001). However, living with family is major determinant of viral suppression.Conclusion: TLD help improved health related quality of life among HIV infected individual and essential in rapid viral suppression.

scholarly journals Depression and Sleep Duration Associated With Health-related Quality of Life in Individuals With Type 2 Diabetes: a Cross-sectional Study in China

2021 ◽  
Author(s):  
Yu Liu ◽  
Beirui Wu ◽  
Hua Xu ◽  
Xu Wan ◽  
Huichao Wu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Sleep Duration ◽  
Index Score ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eq Vas

Abstract Background: Limited study has evaluated the association among depression, depression and health-related quality of life in individuals with type 2 diabetes in China. We aimed to evaluate the effects of depression and sleep duration on health-related quality of life (HRQoL) in community-based individuals with type 2 diabetes in China.Methods: A total of 1,891 individuals with type 2 diabetes from Pujiang Town, Minhang District, Shanghai, China were included in the study. Self-reported sleep duration per night was obtained by questionnaire. Participant Health Questionnaire-9 (PHQ-9) was used to detect depression. European Quality of Life-5 Dimensions-5 Levels index (EQ-5D-5L) and visual analogue scale (VAS) were used to evaluate the individuals’ HRQoL. Results: The prevalence of depression (PHQ-9 scores ≥5) was 8.9%. The proportion of depression in individuals with sleep duration <7h was higher compared with those with sleep duration of 7-8h and ≥8h, respectively (14% vs. 5.3%, 14% vs. 4.3%, all p < 0.001). Depression was negatively associated with both EQ-5D-5L index score and EQ-VAS (β = -0.1273, 95% CI: -0.1389, -0.1158 for EQ-5D-5L index score; β = -8.8762, 95% CI: -10.3150, -7.4374 for EQ-VAS). Compared to individuals with sleep duration of 7-8h, sleep duration <7h was associated with lower EQ-5D-5L index score and EQ-VAS (β= -0.0242, 95% CI: -0.0116, -0.0367 for EQ-5D-5L index score; β = -2.9386, 95% CI: -1.5210, -4.3562 for EQ-VAS). However, sleep duration ≥8h did not show significant difference in HRQoL before and after full adjustments.Conclusion: To improve quality of life in individuals with type 2 diabetes in China, those with depression and shorter sleep duration may be identified as at-risk populations. Longer sleep duration over 8h might not further improve the quality of life for individuals with type 2 diabetes.

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