scholarly journals The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study

2018 ◽  
Vol 18 (2) ◽  
pp. 136-144.e7 ◽  
Author(s):  
Valeria Santini ◽  
Antonio Almeida ◽  
Aristoteles Giagounidis ◽  
Uwe Platzbecker ◽  
Rena Buckstein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myelodysplastic Syndromes ◽  
Lower Risk ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals The anemia-independent impact of myelodysplastic syndromes on health-related quality of life

2021 ◽  
Author(s):  
Hanneke J. C. M. Wouters ◽  
Annette Conrads-Frank ◽  
Karin A. Koinig ◽  
Alex Smith ◽  
Ge Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Myelodysplastic Syndromes ◽  
Lower Risk ◽  
Large Population ◽  
Index Score ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

AbstractMyelodysplastic syndromes (MDS) are in the majority of cases characterized by anemia. Both anemia and MDS per se may directly contribute to impairments in health-related quality of life (HRQoL). In this study, we aimed to investigate the anemia-independent impact of MDS on HRQoL. We evaluated participants (≥ 50 years) from the large population-based Lifelines cohort (N = 44,694, mean age 59.0 ± 7.4 years, 43.6% male) and the European MDS Registry (EUMDS) (N = 1538, mean age 73.4 ± 9.0 years, 63.0% male), which comprises a cohort of lower-risk MDS patients. To enable comparison concerning HRQoL, SF-36 scores measured in Lifelines were converted to EQ-5D-3L index (range 0–1) and dimension scores. Lower-risk MDS patients had significantly lower HRQoL than those from the Lifelines cohort, as illustrated in both the index score and in the five different dimensions. Multivariable linear regression analysis demonstrated that MDS had an adjusted total impact on the EQ-5D index score (B =  − 0.12, p < 0.001) and an anemia-independent “direct” impact (B =  − 0.10, p < 0.001). Multivariable logistic regression analysis revealed an anemia-independent impact of MDS in the dimension mobility, self-care, usual activities, and anxiety/depression (all except pain/discomfort). This study demonstrates that the major part of the negative impact of lower-risk MDS on HRQoL is not mediated via anemia. Thus, the therapeutic focus should include treatment strategies directed at underlying pathogenic mechanisms to improve HRQoL, rather than aiming predominantly at increasing hemoglobin levels.

scholarly journals Health-related quality of life and risk of hospitalization in a healthy general population

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Bonaccio ◽  
A Di Castelnuovo ◽  
S Costanzo ◽  
M Persichillo ◽  
A De Curtis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Lower Risk ◽  
Hospital Admissions ◽  
Short Form ◽  
Significant Proportion ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background The association of health-related quality of life (HRQL) with total and cardiovascular (CVD) hospitalization was assessed in a population-based cohort of apparently healthy subjects; several pathways possibly accounting for such associations were also tested. Methods Longitudinal analysis on 16,849 subjects free from CVD and cancer from the Moli-sani Study, Italy (2005-2010). HRQL was performed by the 36-Item Short Form Health Survey including both mental and physical domains. First hospital admissions were recorded by direct linkage with hospital discharge form registry. Hazard ratios (HR) with 95% confidence interval (95%CI) were calculated by multivariable Cox-regression. Results Over a median follow-up of 7.3 y, 6,061 all-cause, 1907 CVD, 431 IHD and 294 stroke hospital admissions were ascertained. The highest quintile of mental HRQL was associated with 23% (95%CI: 17% to 29%), 26% (15% to 36%) and 30% (5% to 48%) lower risk of total, CVD and IHD admissions to hospital, respectively, as compared to the lowest. Risk estimates for physical health were 0.60 (0.56-0.65 for Q5 vs Q1), 0.57 (0.50-0.65) and 0.73 (0.55-0.97) for total, CVD and IHD hospital admissions, respectively. A downward trend with stroke hospitalizations was found for both mental and physical HRQL. Healthy behaviours explained up to 13% of the association between mental HRQL and IHD risk; inflammatory markers (i.e. C-reactive protein and white blood cell count)) accounted for a significant proportion (34%) of the association of physical HRQL with IHD hospitalizations. Conclusions In a large sample of disease-free subjects, not only physical, but also higher mental HRQL is associated with lower risk of total and CVD hospitalizations. Key messages HRQL adds meaningful information beyond traditional risk factors to the prediction of hospitalization. HRQL assessment may be useful in stratifying hospitalization risk among a general population of healthy adults.

scholarly journals Targeting health-related quality of life in patients with myelodysplastic syndromes – Current knowledge and lessons to be learned

Blood Reviews ◽  
2021 ◽  
pp. 100851
Author(s):  
Esther N. Oliva ◽  
Uwe Platzbecker ◽  
Pierre Fenaux ◽  
Guillermo Garcia-Manero ◽  
Thomas W. LeBlanc ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myelodysplastic Syndromes ◽  
Current Knowledge ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Health-Related Quality of Life Profile and Request of Prognostic Information on Survival At the Time of Diagnosis in Patients with High-Risk Myelodysplastic Syndromes

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2078-2078
Author(s):  
Fabio Efficace ◽  
Gianluca Gaidano ◽  
Reinhard Stauder ◽  
Giovanni Caocci ◽  
Maria Teresa Voso ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Risk ◽  
Myelodysplastic Syndromes ◽  
Health Related Quality ◽  
Prognostic Information ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Abstract Abstract 2078 Background: Health-related quality of life profile (HRQOL) of patients diagnosed with high-risk myelodysplastic syndromes (MDS) can be compromised already at the time of diagnosis before receiving any kind of treatment. Clinical decision-making is challenging due to the poor prognosis and no data exist on the possible relationships between patient's HRQOL and the request of prognostic information on survival during consultation. Aim: The main objectives were to assess preferences for prognostic information of patients with high-risk MDS and the relationship between such preferences and patient characteristics including HRQOL. To date no such evidence exists in this population. Patients and Methods: Data were gathered through an ongoing international prospective observational study that recruits newly diagnosed patients with MDS. These patients typically have a limited life expectancy. At the time of diagnosis, and during one of the first clinical consultations in which treatment options were discussed, patients completed the European Organization for Research and treatment of Cancer, Quality of life Questionnaire (EORTC QLQ-C30). The EORTC QLQ-C30 is a psychometrically robust generic HRQOL cancer measure assessing both symptoms and functional aspects. Physicians also completed an extensive survey about their patient's preference for involvement in treatment decisions and whether the patient explicitly requested prognostic information for survival. Associations between request for prognostic information, HRQOL socio-demographic characteristics (i.e., living arrangements, age, gender, education) and clinical data including: performance status, comorbidity and disease severity (i.e. IPSS risk category intermediate 2 vs. high risk) were investigated using Fisher's exact test and Wilcoxon-Mann-Whitney test as appropriate. Results: Overall, 184 patients (36% female and 64% male) were analyzed. Mean age of patients was 70 years (range: 31–88). 65% explicitly requested information about expected survival at the time of diagnosis. The symptom profile of patients requesting prognostic information was better than those who did not in 7 out of the 8 symptoms evaluated. The largest clinically meaningful difference was found for fatigue with a mean score of 39 (SD:26) and 52 (SD:28) respectively for those requesting prognostic information versus those who did not. Request for prognostic information was significantly associated with younger age (P=.01) and fewer comorbidities (P=.04). In addition, better physical functioning (P=.009), better role functioning (P=.002) and a lower level of fatigue (P=.002) were also associated with a request for prognostic information during consultation. Additional supportive analysis revealed that patients with a higher overall mean symptom score did not request information about survival (P=.02). Conclusion: These data suggest that the majority of patients with high-risk MDS request prognostic information on survival from their physicians at the time of diagnosis. There is also an indication that patients who are more likely to request such information are those who are in better health condition reporting higher functional abilities and lower symptoms. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study

Leukemia ◽  
2018 ◽  
Vol 32 (6) ◽  
pp. 1380-1392 ◽  
Author(s):  
Reinhard Stauder ◽  
Ge Yu ◽  
Karin A. Koinig ◽  
Tim Bagguley ◽  
Pierre Fenaux ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lower Risk ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Age And Sex
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