scholarly journals Cerebrospinal fluid penetration of the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, pexidartinib

2020 ◽  
Vol 85 (5) ◽  
pp. 1003-1007 ◽  
Author(s):  
Priya S. Shankarappa ◽  
Cody J. Peer ◽  
Arman Odabas ◽  
Cynthia L. McCully ◽  
Rafael C. Garcia ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Colony Stimulating Factor ◽  
Fluid Penetration ◽  
Stimulating Factor

Human macrophage colony-stimulating factor levels in cerebrospinal fluid

Cytokine ◽  
1993 ◽  
Vol 5 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Kazuya Shimoda ◽  
Seiichi Okamura ◽  
Yumi Mizuno ◽  
Naoki Harada ◽  
Akira Kubota ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Macrophage ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

The effects of topical granulocyte-macrophage colony–stimulating factor on dural healing in rats after induced cerebrospinal fluid leakage

2007 ◽  
Vol 7 (4) ◽  
pp. 419-422
Author(s):  
Gökhan Kurt ◽  
Alp Özgün Börcek ◽  
Berker Cemil ◽  
NeşE Lortlar Uçankuş ◽  
Fikret Doğulu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Leakage ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Fluid Leakage ◽  
Recombinant Mouse ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Dural Defects ◽  
Stimulating Factor

Object Dural defects must be repaired to protect the central nervous system from contamination. Although there are various experimental and commercial substances available for this purpose, the ultimate method of watertight dural closure has yet to be discovered. In this study, the authors investigate the effects of topically applied recombinant mouse granulocyte-macrophage colony–stimulating factor (GM-CSF) on dural healing in a rat model of dural injury and cerebrospinal fluid leakage. Methods In this experimental model, a dural defect at the level of the L1–2 vertebrae was created in 32 Wistar rats. Sixteen animals were treated with locally applied recombinant mouse GM-CSF postoperatively, and 16 animals received normal saline. The effects of GM-CSF on dural healing, cerebrospinal fluid leakage, and wound healing were assessed 2 and 4 weeks postoperatively. Dural healing was evaluated histologically. Results Dural healing was increased in rats treated with GM-CSF compared with rats in the control group. This difference was statistically significant (p < 0.05). Conclusions Cerebrospinal fluid leakage may impede healing of dural defects. Topically applied GM-CSF seems to aid in dural healing.

Detection of Granulocyte-Macrophage Colony-Stimulating Factor in Cerebrospinal Fluid of Patients with Aseptic Meningitis

1991 ◽  
Vol 86 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Kazuya Shimoda ◽  
Seiichi Okamura ◽  
Fusayuki Omori ◽  
Yumi Mizuno ◽  
Toshiro Hara ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Aseptic Meningitis ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Granulocyte-macrophage colony-stimulating factor activity in cerebrospinal fluid

2009 ◽  
Vol 100 (4) ◽  
pp. 274-277 ◽  
Author(s):  
A. Leonardi ◽  
S. Penco ◽  
C. Gramigni ◽  
C. Bason ◽  
G. Ribizzi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Colony Stimulating Factor ◽  
Factor Activity ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid

1990 ◽  
Vol 29 (1-3) ◽  
pp. 105-112 ◽  
Author(s):  
P GALLO ◽  
S PAGNI ◽  
B GIOMETTO ◽  
M PICCINNO ◽  
F BOZZA ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
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