Gene Organization and Sequence Determination of the Two Botulinum Neurotoxin Gene Clusters in Clostridium botulinum Type A(B) Strain NCTC 2916

1998 ◽  
Vol 36 (4) ◽  
pp. 226-231 ◽  
Author(s):  
Mar Rodríguez Jovita ◽  
Matthew D. Collins ◽  
Alison K. East
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Gene Clusters ◽  
Gene Organization ◽  
Sequence Determination ◽  
Strain Nctc ◽  
Botulinum Type

Complete DNA sequences of the botulinum neurotoxin complex of Clostridium botulinum type A-Hall (Allergan) strain

Gene ◽  
2003 ◽  
Vol 315 ◽  
pp. 21-32 ◽  
Author(s):  
Li Zhang ◽  
Wei-Jen Lin ◽  
Shengwen Li ◽  
K.Roger Aoki
Keyword(s):  
Dna Sequences ◽  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Botulinum Type ◽  
Neurotoxin Complex

scholarly journals Two-Component Systems Are Involved in the Regulation of Botulinum Neurotoxin Synthesis in Clostridium botulinum Type A Strain Hall

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41848 ◽  
Author(s):  
Chloé Connan ◽  
Holger Brueggemann ◽  
Christelle Mazuet ◽  
Stéphanie Raffestin ◽  
Nadège Cayet ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Component Systems ◽  
Two Component ◽  
Botulinum Type ◽  
Two Component Systems

scholarly journals Correction: Two-Component Systems Are Involved in the Regulation of Botulinum Neurotoxin Synthesis in Clostridium botulinum Type A Strain Hall

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
Author(s):  
Chloé Connan ◽  
Holger Brüggemann ◽  
Christelle Mazuet ◽  
Stéphanie Raffestin ◽  
Nadège Cayet ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Component Systems ◽  
Two Component ◽  
Botulinum Type ◽  
Two Component Systems

Neurotoxin Gene Clusters in Clostridium botulinum Type A Strains: Sequence Comparison and Evolutionary Implications

2003 ◽  
Vol 46 (5) ◽  
pp. 345-352 ◽  
Author(s):  
Sean S. Dineen ◽  
Marite Bradshaw ◽  
Eric A. Johnson
Keyword(s):  
Sequence Comparison ◽  
Clostridium Botulinum ◽  
Type A ◽  
Gene Clusters ◽  
Botulinum Type

Subunit Stoichiometry of the Clostridium botulinum Type A Neurotoxin Complex Determined Using Denaturing Capillary Electrophoresis

2008 ◽  
Vol 27 (7-8) ◽  
pp. 420-425 ◽  
Author(s):  
Michael A. Lietzow ◽  
Elizabeth T. Gielow ◽  
Denise Le ◽  
Jifeng Zhang ◽  
Marc F. Verhagen
Keyword(s):  
Capillary Electrophoresis ◽  
Clostridium Botulinum ◽  
Type A ◽  
Subunit Stoichiometry ◽  
Botulinum Type ◽  
Neurotoxin Complex

scholarly journals Wound botulism in injectors of drugs: upsurge in cases in England during 2004

2005 ◽  
Vol 10 (9) ◽  
pp. 5-6 ◽  
Author(s):  
D Akbulut ◽  
J Dennis ◽  
M Gent ◽  
K A Grant ◽  
V Hope ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Wound Infections ◽  
Republic Of Ireland ◽  
Wound Botulism ◽  
Geographical Clustering ◽  
The Republic ◽  
The Uk

Wound infections due to Clostridium botulinum were not recognised in the UK and Republic of Ireland before 2000. C. botulinum produces a potent neurotoxin which can cause paralysis and death. In 2000 and 2001, ten cases were clinically recognised, with a further 23 in 2002, 15 in 2003 and 40 cases in 2004. All cases occurred in heroin injectors. Seventy cases occurred in England; the remainder occurred in Scotland (12 cases), Wales (2 cases) and the Republic of Ireland (4 cases). Overall, 40 (45%) of the 88 cases were laboratory confirmed by the detection of botulinum neurotoxin in serum, or by the isolation of C. botulinum from wounds. Of the 40 cases in 2004, 36 occurred in England, and of the 12 that were laboratory confirmed, 10 were due to type A. There was some geographical clustering of the cases during 2004, with most cases occurring in London and in the Yorkshire and Humberside region of northeast England.

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