Evaluation of hearing and cochlear function by DPOAE and audiometric tests in patients with ankylosing spondilitis

AbstractNumerous studies have documented the adverse effects of high-dose radiation on hearing in patients. On the other hand, radiographers are exposed to a low dose of ionizing radiation, and the effect of a low dose of radiation on hearing is quite abstruse. Therefore, the present systematic review aimed to elucidate the effect of low-dose ionizing radiation on hearing. Two authors independently carried out a comprehensive data search in three electronic databases, including PUBMED/MEDLINE, CINAHL, and SCOPUS. Eligible articles were independently assessed for quality by two authors. Cochrane Risk of Bias tool was used assess quality of the included studies. Two articles met the low-dose radiation exposure criteria given by Atomic Energy Regulatory Board (AERB) and National Council on Radiation Protection (NCRP) guidelines. Both studies observed the behavioral symptoms, pure-tone hearing sensitivity at the standard, extended high frequencies, and the middle ear functioning in low-dose radiation-exposed individuals and compared with age and gender-matched controls. One study assessed the cochlear function using transient-evoked otoacoustic emissions (TEOAE). Both studies reported that behavioral symptoms of auditory dysfunction and hearing thresholds at extended high frequencies were higher in radiation-exposed individuals than in the controls. The current systematic review concludes that the low-dose ionizing radiation may affect the hearing adversely. Nevertheless, further studies with robust research design are required to explicate the cause and effect relationship between the occupational low-dose ionizing radiation exposure and hearing.

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Can auditory brain stem response accurately reflect the cochlear function?

Journal of Neurophysiology ◽

10.1152/jn.00233.2020 ◽

2020 ◽

Vol 124 (6) ◽

pp. 1667-1675

Author(s):

Dalian Ding ◽

Jianhui Zhang ◽

Wenjuan Li ◽

Dong Li ◽

Jintao Yu ◽

...

Keyword(s):

Brain Stem ◽

Damage Model ◽

Compound Action Potential ◽

Cochlear Function ◽

Auditory Brain Stem Response ◽

Threshold Difference ◽

Auditory Brain Stem ◽

Cochlear Damage ◽

Brain Stem Response ◽

Compound Action

Auditory brain stem response (ABR) is more commonly used to evaluate cochlear lesions than cochlear compound action potential (CAP). In a noise-induced cochlear damage model, we found that the reduced CAP and enhanced ABR caused the threshold difference. In a unilateral cochlear destruction model, a shadow curve of the ABR from the contralateral healthy ear masked the hearing loss in the destroyed ear.

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CD1 hearing-impaired mice. I: Distortion product otoacoustic emission levels, cochlear function and morphology

Hearing Research ◽

10.1016/s0378-5955(98)00050-1 ◽

1998 ◽

Vol 120 (1-2) ◽

pp. 37-50 ◽

Cited By ~ 40

Author(s):

S Le Calvez ◽

P Avan ◽

L Gilain ◽

R Romand

Keyword(s):

Otoacoustic Emission ◽

Hearing Impaired ◽

Distortion Product Otoacoustic Emission ◽

Cochlear Function ◽

Distortion Product

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Serum melatonin levels in ankylosing spondilitis: correlation with disease activity

Rheumatology International ◽

10.1007/s00296-009-1223-x ◽

2009 ◽

Vol 31 (1) ◽

pp. 61-63 ◽

Cited By ~ 7

Author(s):

Kazim Senel ◽

Tuba Baykal ◽

Meltem Alkan Melikoglu ◽

Akin Erdal ◽

Saliha Karatay ◽

...

Keyword(s):

Disease Activity ◽

Ankylosing Spondilitis

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VASOACTIVE DRUGS AND COCHLEAR FUNCTION

Australian Journal of Experimental Biology and Medical Science ◽

10.1038/icb.1969.115 ◽

1969 ◽

Vol 47 (4) ◽

pp. P-23-P-23

Author(s):

T Morizono ◽

BM Johnstone

Keyword(s):

Vasoactive Drugs ◽

Cochlear Function

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Response Properties of Single Auditory Nerve Fibers in the Mouse

Journal of Neurophysiology ◽

10.1152/jn.00574.2004 ◽

2005 ◽

Vol 93 (1) ◽

pp. 557-569 ◽

Cited By ~ 268

Author(s):

Annette M. Taberner ◽

M. Charles Liberman

Keyword(s):

Auditory Nerve ◽

Dynamic Range ◽

Phase Locking ◽

Nerve Fibers ◽

Cochlear Function ◽

Response Properties ◽

Tuning Curves ◽

Rate Versus ◽

Interstrain Difference ◽

Mutant Lines

The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR (<1 sp/s) had higher thresholds, and wider dynamic ranges than fibers with high SR. Dynamic ranges for mouse high-SR fibers were smaller (<20 dB) than those seen in other mammals. Phase-locking was seen for tone frequencies <4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig.

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Middle Ear Pressure and Dysfunction of the Labyrinth: Is There a Relationship?

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949710600607 ◽

1997 ◽

Vol 106 (6) ◽

pp. 478-482 ◽

Cited By ~ 11

Author(s):

Wolfgang Maier ◽

Milo Fradis ◽

Uwe Ross ◽

Bernhard Richter

Keyword(s):

Eustachian Tube ◽

Middle Ear ◽

Sudden Hearing Loss ◽

Cochlear Function ◽

Pressure Equalization ◽

Middle Ear Pressure ◽

Patient Reported ◽

Tube Dysfunction ◽

Ventilation Tubes ◽

Vestibular Neuronitis

Relationships between middle ear pressure and non-infection-related cochleovestibular dysfunction have been suggested by several authors. According to some data, vertiginous attacks can be prevented by the insertion of a ventilation tube in patients suffering from Meniere's syndrome. The aim of our study was to investigate if the incidence of eustachian tube malfunction and pathologic middle ear pressure is frequent, and if routine implantation of ventilation tubes is reasonable in ears with dysfunctions of the labyrinth, including clinical Meniere's syndrome. So, we determined in our pressure chamber all active and passive parameters of eustachian tube function in 40 patients suffering from Meniere's syndrome, sudden sensory hearing impairment (SSHI), or vestibular neuronitis. Our results disclosed no nonrandom incidence of impaired tubal function among our patients compared to healthy control subjects. Pressure equalization was sufficient in most patients suffering from clinical Meniere's syndrome, and only one patient with vestibular neuronitis presented with a patulous tube. Our results show that impairment of vestibular or cochlear function is not regularly accompanied by eustachian tube dysfunction. Furthermore, no patient reported symptoms while pressure variation was performed. We conclude that variation of middle ear pressure does not usually play a role in the genesis of Meniere's syndrome, vestibular neuronitis, or SSHI. Thus, from our data, we cannot recommend routine implantation of tympanic ventilation tubes in patients suffering from Meniere's syndrome, vestibular neuronitis, or sudden hearing loss.

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