Recovery of cochlear function after cisplatin damage in albino guinea pigs

In attempts to decrease gentamicin ototoxicity, the round windows of guinea pigs were covered with fat before gentamicin was given through the middle ear cavity. Although ototoxicity to the cochlea was reduced, the desired effect on the vestibular sense organs also was reduced, because of the oval window's resistance to drug penetration. In another series of guinea pigs, simple opening of the lateral semicircular canal and covering it with a pledget of Gelfoam soaked with gentamicin was an excellent method for producing a selective vestibular lesion. It is expected to reduce the function of all vestibular sense organs without impairing cochlear function.

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Effects of intense acoustic noise on cochlear function in infant and adult guinea pigs / by Harvey Bruce Abrams.

10.5962/bhl.title.46007 ◽

1980 ◽

Author(s):

Harvey Bruce Abrams

Keyword(s):

Guinea Pigs ◽

Acoustic Noise ◽

Cochlear Function

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Pharmacokinetics of Caroverine in the Inner Ear and Its Effects on Cochlear Function after Systemic and Local Administrations in Guinea Pigs

Audiology and Neurotology ◽

10.1159/000067893 ◽

2003 ◽

Vol 8 (1) ◽

pp. 49-56 ◽

Cited By ~ 15

Author(s):

Zhiqiang Chen ◽

Maoli Duan ◽

Howsung Lee ◽

Runsheng Ruan ◽

Mats Ulfendahl

Keyword(s):

Inner Ear ◽

Guinea Pigs ◽

Cochlear Function

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Differential Effects of Gentamicin on the Distribution of Cochlear Function in Albino and Pigmented Guinea Pigs

Acta Oto-Laryngologica ◽

10.3109/00016489509139331 ◽

1995 ◽

Vol 115 (3) ◽

pp. 367-374 ◽

Cited By ~ 18

Author(s):

John W. Conlee ◽

Margaret L. Bennett ◽

Donnell J. Creel

Keyword(s):

Guinea Pigs ◽

Cochlear Function ◽

Differential Effects

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Guinea Pig Ototoxicity With Hydrocodone and Acetaminophen

Otolaryngology ◽

10.1016/j.otohns.2008.05.524 ◽

2008 ◽

Vol 139 (2_suppl) ◽

pp. P101-P101

Author(s):

Timothy J Hughes ◽

Gregory J Matz ◽

Sam J Marzo

Keyword(s):

Hearing Loss ◽

Guinea Pig ◽

Guinea Pigs ◽

Cell Damage ◽

Case Reports ◽

Human Case ◽

Cochlear Function ◽

Human Hearing ◽

Guinea Pig Model ◽

Chronic Doses

Problem Human case reports have been published demonstrating a rapidly progressive sensorineural hearing loss associated with overuse or abuse of acetaminophen/hydrocodone. We hypothesized that hearing loss would result in the guinea pig model if given high, chronic doses of this drug. Methods Sixty female, pigmented guinea pigs were randomly assigned to a control, acetaminophen, hydrocodone, or acetaminophen/hydrocodone group. All guinea pigs were tested with baseline ABRs on day 0, and post drug/placebo administration on days 30, 60, 90, and 120. At the end of the study 5 animals from each group were sacrificed and their cochleae were harvested for histological investigation. Results No significant change in threshold (dB) was seen between the 4 groups. Histological studies of the cochleae revealed no hair cell damage in any of the groups. Conclusion Hydrocodone and acetaminophen/hydrocodone do not have an obvious deleterious effect on guinea pig cochlear function or structure. Significance This study may indicate that human hearing loss seen with abuse of acetaminophen/hydrocodone is multi-factorial and not just related to the drug abuse alone.

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Cochlear Function of Guinea Pigs with Experimental Chronic Renal Failure

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949910801006 ◽

1999 ◽

Vol 108 (10) ◽

pp. 955-962 ◽

Cited By ~ 11

Author(s):

Toru Ohashi ◽

Mutsumi Kenmochi ◽

Hirotsugu Kinoshita ◽

Kentaro Ochi ◽

Hitoshi Kikuchi

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Guinea Pigs ◽

Cochlear Function

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Electrophysiological measures of cochlear function in guinea pigs with long-term endolymphatic hydrops

Hearing Research ◽

10.1016/0378-5955(84)90071-6 ◽

1984 ◽

Vol 14 (1) ◽

pp. 85-91 ◽

Cited By ~ 32

Author(s):

R.V. Harrison ◽

A.Orsulakova-Meyer zum Gottesberge ◽

J.-P. Erre ◽

N. Mori ◽

J.-M. Aran ◽

...

Keyword(s):

Guinea Pigs ◽

Endolymphatic Hydrops ◽

Cochlear Function

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The effect of systemic administration of desmopressin on cochlear function in guinea pigs

Acta Oto-Laryngologica ◽

10.3109/00016489.2013.771282 ◽

2013 ◽

Vol 133 (7) ◽

pp. 676-684 ◽

Cited By ~ 4

Author(s):

Yasuhiro Chihara ◽

Christopher Wong ◽

Ian S. Curthoys ◽

Daniel J. Brown

Keyword(s):

Guinea Pigs ◽

Systemic Administration ◽

Cochlear Function

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Electrocochleographic Evaluation of the Guinea Pig Model of Endolymphatic Hydrops

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949710601109 ◽

1997 ◽

Vol 106 (11) ◽

pp. 934-942

Author(s):

Mohamed Badr-El-Dine ◽

George M. Gerken ◽

Karen S. Robinson ◽

Charles G. Wright ◽

William L. Meyerhoff

Keyword(s):

Guinea Pig ◽

Guinea Pigs ◽

Endolymphatic Hydrops ◽

Osmotic Dehydration ◽

Pig Model ◽

Sham Operation ◽

Cochlear Function ◽

Summating Potential ◽

Guinea Pig Model ◽

The Right

Electrocochleography (ECochG) was used to evaluate cochlear function in guinea pigs with experimentally induced endolymphatic hydrops (ELH) before and after osmotic dehydration with either glycerol or urea. We surgically induced ELH in the right ears of 9 guinea pigs, while the right ears of 6 guinea pigs received a sham operation. The left ears of the 15 animals constituted the normal group. Eight weeks after surgery, summating potential (SP) and action potential (AP) amplitudes were measured prior to and following the administration of glycerol or urea. The SPs and SP/AP ratios were reduced in all groups, with no significant differences among groups or between dehydrating agents. Some of the hydropic ears, however, did show an increased AP threshold and a recruitment effect. In measurements from 6 additional animals, serum osmolarity increased more with urea than with glycerol. The guinea pig model remains valuable for investigation of ELH, even though it differs in significant respects from ELH in humans.

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