The prevalence and clinical characteristics of anti-HMGCR (anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase) antibodies in idiopathic inflammatory myopathy: an analysis from the MyoCite registry

2022 ◽  
Author(s):  
Latika Gupta ◽  
Arvind Nune ◽  
R. Naveen ◽  
Ritu Verma ◽  
Pallavi Prasad ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Coenzyme A ◽  
Inflammatory Myopathy ◽  
Idiopathic Inflammatory Myopathy ◽  
Coenzyme A Reductase

scholarly journals Recurrent focal myositis developing into a generalised idiopathic inflammatory myopathy with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibodies

2019 ◽  
Vol 12 (11) ◽  
pp. e229787
Author(s):  
Johan Lim ◽  
Leroy Ten Dam ◽  
Paul A Baars ◽  
Anneke J Van der Kooi
Keyword(s):  
Coenzyme A ◽  
Inflammatory Myopathy ◽  
Idiopathic Inflammatory Myopathy ◽  
Muscle Involvement ◽  
First Report ◽  
Immune Mediated ◽  
Immunosuppressant Treatment ◽  
Coenzyme A Reductase

We present the case of a 43-year-old woman with generalised idiopathic inflammatory myopathy (IIM) with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies (Abs) that developed following recurrent focal myositis. Anti-HMGCR Abs are myositis-specific Abs that are associated with immune-mediated necrotising myopathy, a subtype of IIM that is characterised by relatively prominent and severe muscle involvement, generally necessitating multimodal immunosuppressant treatment. While earlier reports have described patients developing polymyositis following focal myositis, this is the first report to describe a patient developing IIM with anti-HMGCR Abs following focal myositis. Thus, clinicians should be aware of the possibility that focal myositis may develop into a generalised IIM and should instruct the patient and monitor the patient accordingly.

Clinical Characteristics of Juvenile Idiopathic Inflammatory Myopathy and Comparison With Adult Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jesús Loarce-Martos ◽  
Carmen Larena ◽  
M. Ángeles Blázquez ◽  
Beatriz E. Joven ◽  
Patricia E. Carreira ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Inflammatory Myopathy ◽  
Idiopathic Inflammatory Myopathy ◽  
Adult Patients

Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month

Circulation ◽  
1997 ◽  
Vol 95 (5) ◽  
pp. 1126-1131 ◽  
Author(s):  
Gerard O'Driscoll ◽  
Danny Green ◽  
Roger R. Taylor
Keyword(s):  
Endothelial Function ◽  
Reductase Inhibitor ◽  
Coenzyme A ◽  
Coenzyme A Reductase
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