Proton magnetic resonance spectroscopy (1H MRS) of human brain tumours: assessment of differences between tumour types and its applicability in brain tumour categorization

2003 ◽  
Vol 13 (3) ◽  
pp. 582-591 ◽  
Author(s):  
Carles Majós ◽  
Juli Alonso ◽  
Carles Aguilera ◽  
Marta Serrallonga ◽  
Javier Pérez-Martín ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Human Brain ◽  
Brain Tumour ◽  
Brain Tumours ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Mrs ◽  
Human Brain Tumours

Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours

1995 ◽  
Vol 37 (2) ◽  
pp. 99-103
Author(s):  
K. Houkin ◽  
K. Kamada ◽  
Y. Sawamura ◽  
Y. Iwasaki ◽  
H. Abe ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumours ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Mrs

scholarly journals 81 IN VIVO PROTON MAGNETIC RESONANCE SPECTROSCOPY (1H-MRS) IN CYSTIC LEUCOMALACIA OF INFANCY

1994 ◽  
Vol 36 (1) ◽  
pp. 16A-16A
Author(s):  
Floris Groenendaal ◽  
Paula Eken ◽  
Jeroen Van Der Grond ◽  
Karin Rademaker ◽  
Linda S De Vries
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Mrs

scholarly journals Association between altered proton magnetic resonance spectroscopy (1H MRS) findings and clinical symptoms of schizophrenia.

2013 ◽  
Vol 74 (1) ◽  
pp. 183-190
Author(s):  
Senair Alberto Ambros ◽  
Paulo Belmonte Abreu ◽  
Eloísa Elena Ferreira ◽  
Pdro Eugenio Ferreira ◽  
Luciana Estacia Ambros
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Clinical Symptoms ◽  
Resonance Spectroscopy ◽  
Thalamic Nuclei ◽  
1H Mrs ◽  
Disorganized Speech ◽  
The Right

Objective: To assess the metabolic alterations of the thalamus in subjects with schizophrenia compared to healthysubjects and to investigate whether specific schizophrenic symptoms are associated with metabolic alterationsmeasured by 1H MRS. Methods: This is a case-control study including patients with schizophrenia diagnosed usingthe Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition, DMS-IV and the Operational CriteriaChecklist for Psychotic Illness (OPCRIT). Proton magnetic resonance spectroscopy (1H MRS) was used to assessmetabolite concentrations (N-acetylaspartate, choline, creatinine, myoionositol and lactacte) in the left and rightthalamus of 13 patients with schizophrenia and 13 healthy controls. Results: In this study, concentrations ofspecific metabolites in the thalamus, determined by 1H MRS, were similar for individuals with schizophrenia andcontrols. It was observed that cases with family history of schizophrenia and disorganized speech demonstrated areduction in the ratio of the metabolites NAA /Cho in the thalamic nuclei on the right side. However, those withorganized delusions, hallucinations and non-affective auditory hallucinations had an increase of metabolites on theright side compared to the left thalamus. Decreased thalamic metabolic activity in patients with positive symptomswas observed in contrast with those who had well-organized delusions and auditory non-affective hallucinations,core symptoms of schizophrenia. Conclusion: A lateralized thalamic involvement was verified, suggesting thatorganic and genetic factors compromise the right thalamus and that the disorganization associated with delusionsand hallucinations compromises the left thalamic nuclei. Further studies to investigate the correlation betweensymptoms and thalamic dysfunction are warranted. (Rev Neuropsiquiatr 2011;74:183-190)

scholarly journals Assessment of Uterine Cervical Cancer by Means of MR Spectroscopy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
Y A M Abdelmawla ◽  
M A A Ali ◽  
F H Ali
Keyword(s):  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Lipid Level ◽  
Resonance Spectroscopy ◽  
Consistent Difference ◽  
1H Mrs ◽  
Clinical Scenarios

Abstract Background Proton magnetic resonance spectroscopy has been shown to have clinical value in managing cancers of the brain, breast, cervix and prostate, it is useful for diagnosing and monitoring treatment of cervical cancer by analyzing the metabolite composition of cervical tumors, providing details of tumors metabolism that might assist tumor grading and leading to a better understanding of the biochemical pathways found within the lesion, serving as a noninvasive biomarker of metabolism in tumors. 1H-MRS has achieved great strides as a molecular imaging technique since its introduction, and its scope in many clinical scenarios and research settings is rising. Objective In this study, MRS was performed in all cases using single voxel spectroscopy (SVS) and patient spectra were interpreted qualitatively by inspection of the peaks of lipid and choline. Aim and Patients and Methods This study was carried out during the period between December 2017 and September 2018. Twenty three patients with cancer cervix diagnosed clinically and/or pathologically proved cancer were recruited from (Oncological department) in Ain Shams University Hospitals. Results Our study revealed high lipid level in 65% of cervical cancer patients which has 100% sensitivity and 74% specificity in detecting cervical cancer, choline level which considered most consistent difference between majority of normal tissue and tumors shows high level in measured 69.2% of the patients. Conclusion Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic. This study interpret ate the role of 1H-MRS for cancer evaluation, evaluates its strengths and limitations, and correlates metabolite peaks at 1H-MRS with diagnostic and prognostic parameters of cervical cancer.

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