Differences in practice patterns between urologists and radiation oncologists in the management of localized prostate cancer: a cross-sectional survey

2015 ◽  
Vol 33 (11) ◽  
pp. 1741-1747 ◽  
Author(s):  
Mehdi Mokhtar Ariane ◽  
Guillaume Ploussard ◽  
Xavier Rebillard ◽  
Bernard Malavaud ◽  
Pascal Rischmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Practice Patterns ◽  
Localized Prostate Cancer ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Radiation Oncologists

Practice Patterns and Attitudes of Surgeons on the Use of Prophylactic Mesh to Prevent Parastomal Hernia: A Cross-sectional Survey

2019 ◽  
Vol 65 (9) ◽  
pp. 14-23 ◽  
Author(s):  
Manuel Lopez-Cano ◽  
Hobart W Harris ◽  
John P Fisher ◽  
Jose Antonio Pereira ◽  
Josep M Garcia-Alamino ◽  
...  
Keyword(s):  
Parastomal Hernia ◽  
Practice Patterns ◽  
Cross Sectional Survey ◽  
Prophylactic Mesh ◽  
Cross Sectional

scholarly journals Addition of Androgen-Deprivation Therapy or Brachytherapy Boost to External Beam Radiotherapy for Localized Prostate Cancer: A Network Meta-Analysis of Randomized Trials

2020 ◽  
Vol 38 (26) ◽  
pp. 3024-3031 ◽  
Author(s):  
William C. Jackson ◽  
Holly E. Hartman ◽  
Robert T. Dess ◽  
Sam R. Birer ◽  
Payal D. Soni ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Randomized Trials ◽  
Practice Patterns ◽  
Meta Analysis ◽  
External Beam Radiotherapy ◽  
Localized Prostate Cancer ◽  
External Beam ◽  
Brachytherapy Boost ◽  
Meta Analyses

PURPOSE In men with localized prostate cancer, the addition of androgen-deprivation therapy (ADT) or a brachytherapy boost (BT) to external beam radiotherapy (EBRT) have been shown to improve various oncologic end points. Practice patterns indicate that those who receive BT are significantly less likely to receive ADT, and thus we sought to perform a network meta-analysis to compare the predicted outcomes of a randomized trial of EBRT plus ADT versus EBRT plus BT. MATERIALS AND METHODS A systematic review identified published randomized trials comparing EBRT with or without ADT, or EBRT (with or without ADT) with or without BT, that reported on overall survival (OS). Standard fixed-effects meta-analyses were performed for each comparison, and a meta-regression was conducted to adjust for use and duration of ADT. Network meta-analyses were performed to compare EBRT plus ADT versus EBRT plus BT. Bayesian analyses were also performed, and a rank was assigned to each treatment after Markov Chain Monte Carlo analyses to create a surface under the cumulative ranking curve. RESULTS Six trials compared EBRT with or without ADT (n = 4,663), and 3 compared EBRT with or without BT (n = 718). The addition of ADT to EBRT improved OS (hazard ratio [HR], 0.71 [95% CI, 0.62 to 0.81]), whereas the addition of BT did not significantly improve OS (HR, 1.03 [95% CI, 0.78 to 1.36]). In a network meta-analysis, EBRT plus ADT had improved OS compared with EBRT plus BT (HR, 0.68 [95% CI, 0.52 to 0.89]). Bayesian modeling demonstrated an 88% probability that EBRT plus ADT resulted in superior OS compared with EBRT plus BT. CONCLUSION Our findings suggest that current practice patterns of omitting ADT with EBRT plus BT may result in inferior OS compared with EBRT plus ADT in men with intermediate- and high-risk prostate cancer. ADT for these men should remain a critical component of treatment regardless of radiotherapy delivery method until randomized evidence demonstrates otherwise.

scholarly journals National survey of radiation oncologists’ practice patterns regarding hormone-naïve prostate cancer with bone metastases

2020 ◽  
Vol 50 (10) ◽  
pp. 1188-1194
Author(s):  
Katsumasa Nakamura ◽  
Hitoshi Ishikawa ◽  
Tetsuo Akimoto ◽  
Manabu Aoki ◽  
Shinji Kariya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Bone Metastases ◽  
Practice Patterns ◽  
Primary Treatment ◽  
Dose Fractionation ◽  
Radiation Oncologists ◽  
Multiple Bone Metastases ◽  
Single Bone ◽  
Radiotherapy Dose

Abstract Objective To explore radiation oncologists’ attitudes and practice patterns of radiotherapy for hormone-naïve prostate cancer with bone metastases in Japan. Methods An internet-based survey was distributed to board-certified radiation oncologists of the Japanese Society of Radiation Oncology. Three hypothetical cases were assumed: hormone-naïve prostate cancer with single, three or multiple non-symptomatic bone metastases. The respondents described their attitude regarding such cases, treatment methods and the radiotherapy dose fractionation that they would recommend. Results Among the 1013 board-certified radiation oncologists in Japan, 373 (36.8%) responded to the questionnaire. Most of the respondents (85.0%) believed that radiotherapy may be applicable as a primary treatment for hormone-naïve prostate cancer with bone metastases in some circumstances. For Case 1 (single bone metastasis), 55.0% of the respondents recommended radiotherapy for the prostate and bone metastasis. For Case 2 (three bone metastases), only 24.4% recommended radiotherapy for all lesions, and 31.4% recommended radiotherapy for the prostate only. For Case 3 (multiple bone metastases), 49.1% of the respondents stated that there was no indication for radiotherapy. However, 34% of the respondents still preferred to administer radiotherapy for the prostate. The radiotherapy techniques and dose fractionations varied widely among the respondents. Conclusion Most of the respondent radiation oncologists believed that radiotherapy may be beneficial for hormone-naïve prostate cancer with bone metastases.

A national survey of radiation oncologists and urologists on prediction tools and nomograms for localized prostate cancer

2019 ◽  
Vol 37 (10) ◽  
pp. 2099-2108 ◽  
Author(s):  
Boris Gershman ◽  
Paul Maroni ◽  
Jon C. Tilburt ◽  
Robert J. Volk ◽  
Badrinath Konety ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
National Survey ◽  
Localized Prostate Cancer ◽  
Prediction Tools ◽  
Radiation Oncologists

Impact of skeletal related events (SREs) on health-related quality of life (HRQoL) and healthcare resource utilization (HRU) in prostate cancer patients with bone metastases (BM).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e16046-e16046
Author(s):  
Jorge Arellano ◽  
Kristina S Chen ◽  
Carolyn Atchison ◽  
Alex Rider ◽  
Andrew Worsfold ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Negative Impact ◽  
Underlying Disease ◽  
Cord Compression ◽  
Healthcare Resource Utilization ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Cancer Disease ◽  
The Impact

e16046 Background: Advanced prostate cancer often leads to the development of BM and as a result SREs. Treatment and management of SREs, as well as the underlying disease, influences the patient’s HRQoL and HRU. We evaluated the impact of SREs on HRQoL (FACT-P) and HRU in patients with BM. Methods: Data were extracted from the Adelphi Prostate Cancer Disease-Specific Programme (DSP), a cross-sectional survey of 150 urologists and oncologists and their prostate cancer patients conducted from March to June 2012 in the US. Each specialist completed comprehensive record forms on 12 of their patients being treated for prostate cancer. Patients were invited to complete a questionnaire, which included the FACT-P HRQoL instrument. Patients were stratified by SRE experience to assess the impact of SRE on patients with BM. SRE was defined as an event of bone radiation, bone surgery, fracture, or spinal cord compression. Results: Data were collected from 1,749 prostate cancer patients, of which 941 were identified with BM; SRE status was recorded in 499 BM patients (Table). HRQoL was significantly lower in patients experiencing SREs, while the rate of consultations and likelihood of being hospitalized was significantly higher. Conclusions: SREs result in a significant economic burden on the healthcare system and negative impact on HRQoL in prostate cancer patients with BM. [Table: see text]

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