The role of central CB2 cannabinoid receptors on food intake in neonatal chicks

2011 ◽  
Vol 197 (12) ◽  
pp. 1143-1147 ◽  
Author(s):  
L. Emadi ◽  
H. Jonaidi ◽  
E. Hosseini Amir Abad
Keyword(s):  
Food Intake ◽  
Cannabinoid Receptors ◽  
Neonatal Chicks

Interaction Between Central Opioidergic and Glutamatergic Systems on Food Intake in Neonatal Chicks: Role of NMDA, AMPA and mGLU1 Receptors

2017 ◽  
Vol 24 (1) ◽  
pp. 157-169 ◽  
Author(s):  
Mahshid Torkzaban ◽  
Morteza Zendehdel ◽  
Vahab Babapour ◽  
Negar Panahi ◽  
Shahin Hassanpour
Keyword(s):  
Food Intake ◽  
Neonatal Chicks

scholarly journals Cannabinoids Modulate Food Preference and Consumption in Drosophila Melanogaster

2020 ◽  
Author(s):  
Jianzheng He ◽  
Alice Tan ◽  
Si Ng ◽  
Fengwei Yu
Keyword(s):  
Drosophila Melanogaster ◽  
Food Intake ◽  
Food Preference ◽  
Cannabinoid Receptors ◽  
Fruit Fly ◽  
Inhibitory Effect ◽  
Feeding Behaviors ◽  
Independent Manner ◽  
Inhibit Food Intake

Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of their sensory functions. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

scholarly journals Cannabinoids modulate food preference and consumption in Drosophila melanogaster

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jianzheng He ◽  
Alice Mei Xien Tan ◽  
Si Yun Ng ◽  
Menglong Rui ◽  
Fengwei Yu
Keyword(s):  
Drosophila Melanogaster ◽  
Food Intake ◽  
Food Preference ◽  
Cannabinoid Receptors ◽  
Fruit Fly ◽  
Inhibitory Effect ◽  
Feeding Behaviors ◽  
Independent Manner ◽  
Inhibit Food Intake

AbstractCannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

scholarly journals Cannabinoids modulate food preference and consumption in Drosophila melanogaster

2020 ◽  
Author(s):  
Jianzheng He ◽  
Alice Mei Xien Tan ◽  
Si Yun Ng ◽  
Fengwei Yu
Keyword(s):  
Drosophila Melanogaster ◽  
Food Intake ◽  
Food Preference ◽  
Cannabinoid Receptors ◽  
Fruit Fly ◽  
Inhibitory Effect ◽  
Feeding Behaviors ◽  
Independent Manner ◽  
Inhibit Food Intake

AbstractCannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of their sensory functions. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRF1 /CRF2 and H1/ H3 receptors

2017 ◽  
Vol 42 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Hooman Heidarzadeh ◽  
Morteza Zendehdel ◽  
Vahab Babapour ◽  
Hasan Gilanpour
Keyword(s):  
Food Intake ◽  
H3 Receptors ◽  
Neonatal Chicks

The role of GABAergic system on the inhibitory effect of ghrelin on food intake in neonatal chicks

2012 ◽  
Vol 520 (1) ◽  
pp. 82-86 ◽  
Author(s):  
H. Jonaidi ◽  
L. Abbassi ◽  
M.M. Yaghoobi ◽  
H. Kaiya ◽  
D.M. Denbow ◽  
...  
Keyword(s):  
Food Intake ◽  
Inhibitory Effect ◽  
Gabaergic System ◽  
Neonatal Chicks

scholarly journals On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors

2021 ◽  
Vol 22 (1) ◽  
pp. 398
Author(s):  
Mariangela Pucci ◽  
Elizabeta Zaplatic ◽  
Maria Vittoria Micioni Di Bonaventura ◽  
Emanuela Micioni Di Bonaventura ◽  
Paolo De Cristofaro ◽  
...  
Keyword(s):  
Food Intake ◽  
Eating Behaviors ◽  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Endocannabinoid System ◽  
Central Type ◽  
Type 1 Cannabinoid Receptor

Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.

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