A prospective study of corpus callosum regional volumes and neurocognitive outcomes following cranial radiation for pediatric brain tumors

2017 ◽  
Vol 33 (6) ◽  
pp. 965-972 ◽  
Author(s):  
Arif Rashid ◽  
Ashwin N. Ram ◽  
Wendy R. Kates ◽  
Kristin J. Redmond ◽  
Moody Wharam ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Corpus Callosum ◽  
Prospective Study ◽  
Pediatric Brain Tumors ◽  
Cranial Radiation ◽  
Neurocognitive Outcomes ◽  
A Prospective Study ◽  
Pediatric Brain

scholarly journals Correction to: A prospective study of corpus callosum regional volumes and neurocognitive outcomes following cranial radiation for pediatric brain tumors

2017 ◽  
Vol 33 (12) ◽  
pp. 2215-2215
Author(s):  
Arif Rashid ◽  
Ashwin N. Ram ◽  
Wendy R. Kates ◽  
Kristin J. Redmond ◽  
Moody Wharam ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Corpus Callosum ◽  
Prospective Study ◽  
Pediatric Brain Tumors ◽  
Cranial Radiation ◽  
Neurocognitive Outcomes ◽  
A Prospective Study ◽  
Pediatric Brain

Motor Dysfunction Following Cranial Irradiation for Pediatric Brain Tumors: A Prospective Study

2012 ◽  
Vol 84 (3) ◽  
pp. S66-S67
Author(s):  
K.J. Redmond ◽  
E.M. Mahone ◽  
S. Terezakis ◽  
L. Kleinberg ◽  
T. McNutt ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Prospective Study ◽  
Pediatric Brain Tumors ◽  
Cranial Irradiation ◽  
Motor Dysfunction ◽  
A Prospective Study ◽  
Pediatric Brain

scholarly journals Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study

2014 ◽  
Vol 9 (3) ◽  
pp. 216
Author(s):  
MohanaRao Patibandla ◽  
Suchanda Bhattacharjee ◽  
AniruddhKumar Purohit ◽  
MeghaS Uppin
Keyword(s):  
Brain Tumors ◽  
Prospective Study ◽  
Pediatric Brain Tumors ◽  
A Prospective Study ◽  
Pediatric Brain

Delayed cognitive, behavioral, and radiological changes related to canial irradiation for pediatric brain tumors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20023-20023
Author(s):  
M. M. Abdel Wahab ◽  
H. Hussien ◽  
K. M. Maher
Keyword(s):  
White Matter ◽  
Brain Tumors ◽  
Visual Memory ◽  
Statistical Significance ◽  
Pediatric Brain Tumors ◽  
Low Grade ◽  
White Matter Damage ◽  
Cranial Radiation ◽  
Pediatric Brain

20023 Purpose: To evaluate the delayed adverse changes in neuro-cognitive functions as well as white matter damage in radiated survivors of pediatric brain tumors. Methods: Forty two children (22 males) with primary brain tumors who were only treated with cranial radiation, were recruited. 28 patients were treated for low risk medulloblastoma, 10 patients for low grade astrocytoma, 3 patients for low grade ependymoma, and 1 patient for craniopharyngioma. Their ages ranged from 3 to 18 years (mean 10.3±3.98 years).They were subjected, initially just before radiotherapy and at follow-up 1–2 year after completion of cranial radiation, to serial clinical and neuropsychological assessments including Wechseler Intelligence Scale for Children, Vineland social maturity test, Benton Visual Memory Test, and Revised Behavior Problem Checklist. Magnetic resonance scans were also performed to detect the presence of white matter damage before radiotherapy and at follow up. Results: Initially, after surgery and before radiation, intelligence test scores were below normal scores for age and this was of high statistical significance (Total IQ: t= -3.02, P= 0.006). Visual memory test showed evidence of organicity in all cases. Social maturity showed a statistically significant decline as well (t= -2.11, P= 0.04). Follow-up after radiotherapy showed further decline with high statistical significance (Total IQ t= 3.228, P=0.003; visual memory t= 4.08, P= 0.001); An attentional problem has emerged (t= -6.12, P= 0.00). Both radiation dose and volume of radiation showed negative and statistically significant correlation with IQ. Age at diagnosis correlated positively and significantly with IQ ( r= 0.601, P=0.001). Multiple linear regression showed impaired neurocognitive function which was correlated with the degree of white matter damage. (standardized B= -0.577, P= 0.001) and young age at diagnosis (standardized B= -0.427, P= 0.014). Conclusions: Cranial radiation in pediatric brain tumors is associated with a decline in multiple neurocognitive functions including total IQ, visual memory, and attention; which are related to the toxic effect of cranial radiation on white matter of the brain especially in young age of childhood with high dose and whole cranial radiation. No significant financial relationships to disclose.

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