Preoperative factors associated with prolonged postoperative in-hospital length of stay in patients with Crohn’s disease undergoing intestinal resection or strictureplasty

Abstract Background Postoperative complications might not be accurately registered, leading to weakness in registry data studies. Aim To investigate factors that influence postoperative in-hospital length of stay (LOS) in patients with Crohn’s disease (CD) undergoing bowel surgery. Furthermore, the study aimed to evaluate LOS as a surrogate for postoperative outcome. Methods A multicentre retrospective cohort study. Inclusion criteria were adult patients with CD who underwent bowel surgery with either anastomosis or stricturoplasty. All timings of surgeries are regardless of the method of access to the abdominal cavities. Patients with stoma were excluded. Demographic data, preoperative medications, previous operations for CD, preoperative sepsis, and operation was recorded. The primary outcome was LOS while the secondary outcome variable was postoperative complications. Results 449 patients who underwent abdominal surgery for CD were included. 265/449 (59%) were female. Median age was 37 years (IQR =20), median LOS was seven days (IQR =6). Patients with longer LOS had higher rates of re-laparotomy/re-laparoscopy (45/228 (19.7%) vs. 9/219 (4.1%) p = 0.01). In multivariate analysis, age (OR = 1.024 [CI 95% 1.007–1.041], p = 0.005), preoperative intra-abdominal abscess (OR =0.39 [CI 95% 0.185–0.821], p = 0.013), and previous laparotomy/laparoscopy (Or = 0.57 [CI 95% 0.334–0.918], p = 0.021) were associated with prolonged LOS. LOS correlated with postoperative complications after adjustment for age, gender, previous laparotomy/laparoscopy, and preoperative intra-abdominal abscesses (OR = 1.28 [CI 95% 1.199–1.366], p < 0.0001). Conclusion Age, preoperative intra-abdominal abscess, and previous laparotomy/laparoscopy significantly prolonged LOS. LOS correlated with postoperative complications and can, therefore, act as a surrogate for the postoperative outcome.

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Su1892 - Factors Associated with Intestinal Resection in Crohn's Disease Patients with Bowel Damage Progression as Assessed by Lemann Index

Gastroenterology ◽

10.1016/s0016-5085(18)32238-8 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-622-S-623

Author(s):

Petros Zezos ◽

Tanya P. Chawla ◽

Adam Weizman ◽

Geoffrey C. Nguyen ◽

Raquel Milgrom ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Intestinal Resection ◽

Factors Associated ◽

Damage Progression

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Perioperative Factors Associated with Prolonged Intensive Care Unit and Hospital Length of Stay after Pediatric Neurosurgery

Pediatric Neurosurgery ◽

10.1159/000339312 ◽

2011 ◽

Vol 47 (6) ◽

pp. 423-429 ◽

Cited By ~ 5

Author(s):

Eduardo Mekitarian Filho ◽

Werther Brunow de Carvalho ◽

Sérgio Cavalheiro ◽

Nelson Kazunobu Horigoshi ◽

Norberto Antonio Freddi

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Length Of Stay ◽

Pediatric Neurosurgery ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Factors Associated

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FACTORS ASSOCIATED WITH INPATIENT ENDOSCOPY DELAY AND ITS IMPACT ON HOSPITAL LENGTH-OF-STAY AND 30-DAY READMISSION

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2021.06.009 ◽

2021 ◽

Author(s):

Chelsea C. Jacobs ◽

Johnny F. Jaber ◽

Michael Ladna ◽

Sandeep Ponniah ◽

Ishaan Madhok ◽

...

Keyword(s):

Length Of Stay ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Factors Associated

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Medicaid payer status and other factors associated with hospital length of stay in patients undergoing primary lumbar spine surgery

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2019.105570 ◽

2020 ◽

Vol 188 ◽

pp. 105570 ◽

Cited By ~ 3

Author(s):

Jose F. Dominguez ◽

Piyush Kalakoti ◽

Xintong Chen ◽

Kaisen Yao ◽

Nam K. Lee ◽

...

Keyword(s):

Lumbar Spine ◽

Length Of Stay ◽

Spine Surgery ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Lumbar Spine Surgery ◽

Factors Associated

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A population-based study of the epidemiology of acute adult burn injuries in the Calgary Health Region and factors associated with mortality and hospital length of stay from 1995 to 2004

Burns ◽

10.1016/j.burns.2008.10.003 ◽

2009 ◽

Vol 35 (4) ◽

pp. 572-579 ◽

Cited By ~ 46

Author(s):

Kirsteen R. Burton ◽

Vishal K. Sharma ◽

Robertson Harrop ◽

Robert Lindsay

Keyword(s):

Length Of Stay ◽

Population Based ◽

Hospital Length ◽

Burn Injuries ◽

Hospital Length Of Stay ◽

Population Based Study ◽

Factors Associated ◽

Health Region ◽

Calgary Health Region

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Correction: Risk factors associated with prolonged hospital length-of-stay: 18-year retrospective study of hospitalizations in a tertiary healthcare center in Mexico

PLoS ONE ◽

10.1371/journal.pone.0209944 ◽

2018 ◽

Vol 13 (12) ◽

pp. e0209944

Author(s):

Keyword(s):

Risk Factors ◽

Retrospective Study ◽

Length Of Stay ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Factors Associated ◽

Healthcare Center ◽

Tertiary Healthcare ◽

Prolonged Hospital

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Infusion-related angioedema associated with infliximab-abda: Case report

American Journal of Health-System Pharmacy ◽

10.1093/ajhp/zxaa321 ◽

2020 ◽

Vol 78 (2) ◽

pp. 108-112

Author(s):

Kyle Herndon ◽

Alexandra Dewitt ◽

Amanda Gillion ◽

Debendra Pattanaik

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Supportive Care ◽

White Male ◽

General Medicine ◽

Hospital Length ◽

Hospital Length Of Stay ◽

Tongue Swelling ◽

Medical Intensive Care ◽

Time Of Presentation

Abstract Purpose A case of infusion-related angioedema associated with the use of an infliximab biosimilar (infliximab-abda) is reported in order to bring awareness that this adverse effect is still highly possible in biosimilars, similar to the reference infliximab biologic. Summary A 37-year-old white male with a past medical history significant for ileocolonic fistulizing Crohn’s disease, depression, and gastroesophageal reflux disease (GERD) presented to an emergency department with shortness of breath, urticaria, and tongue swelling that had developed shortly after initiation of an infusion of infliximab-abda. The patient had no documented allergies at the time of presentation. The patient was taking oral budesonide 9 mg daily and oral azathioprine 50 mg daily for treatment of Crohn’s disease. Other medications included oral omeprazole 40 mg every morning for GERD and oral sertraline 100 mg daily for depression. The patient’s tongue swelling worsened, and he was intubated for airway protection. The patient received supportive care treatment for angioedema with intravenous (IV) dexamethasone 8 mg every 8 hours, IV diphenhydramine 50 mg every 8 hours, and IV famotidine 20 mg every 12 hours. He was extubated approximately 43 hours later and observed overnight in a medical intensive care unit. He was transferred to a general medicine unit the next day for further care. The total hospital length of stay was 4 days. Conclusion A 37-year-old man developed infusion-related angioedema with use of infliximab-abda. Discontinuation of the biosimilar product along with supportive care brought about resolution of angioedema. There are no prior published reports of infusion-related angioedema reactions secondary to infliximab-abda use.

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