Is diversion free ileal pouch-anal anastomosis a safe procedure? A meta-analysis of 4973 cases

2021 ◽  
Author(s):  
Khalid Khan ◽  
Talha Manzoor ◽  
Sarah Khan ◽  
John E. Hartley
Keyword(s):  
Ileal Pouch ◽  
Meta Analysis ◽  
Ileal Pouch Anal Anastomosis ◽  
Safe Procedure ◽  
Anal Anastomosis

Ileal Pouch Anal Anastomosis in the Elderly: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Karina E. Pedersen ◽  
Xue Jia ◽  
Stefan D. Holubar ◽  
Scott R. Steele ◽  
Amy L. Lightner
Keyword(s):  
Systematic Review ◽  
Ileal Pouch ◽  
Meta Analysis ◽  
The Elderly ◽  
Ileal Pouch Anal Anastomosis ◽  
Anal Anastomosis

808 FECAL CALPROTECTIN FOR DETECTING POUCHITIS FOLLOWING ILEAL POUCH ANAL ANASTOMOSIS IN ULCERATIVE COLITIS PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1532-S-1533
Author(s):  
Tyler McKechnie ◽  
Yung Lee ◽  
Colin Kruse ◽  
Karim Ramji ◽  
Aristithes Doumouras ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Ileal Pouch ◽  
Meta Analysis ◽  
Fecal Calprotectin ◽  
Ileal Pouch Anal Anastomosis ◽  
Anal Anastomosis

Can a Meta-Analysis Answer the Question: Is Mucosectomy and Handsewn or Double-Stapled Anastomosis Better in Ileal Pouch-Anal Anastomosis?

2006 ◽  
Vol 72 (10) ◽  
pp. 912-916 ◽  
Author(s):  
Stefanie J. Schluender ◽  
Ling Mei ◽  
Huiying Yang ◽  
Phillip R. Fleshner
Keyword(s):  
Functional Outcome ◽  
Statistical Power ◽  
Randomized Trials ◽  
Ileal Pouch ◽  
Meta Analysis ◽  
Ileal Pouch Anal Anastomosis ◽  
Postoperative Function ◽  
Significant Difference ◽  
Anal Anastomosis ◽  
Patient Groups

Although ileal pouch-anal anastomosis (IPAA) is the procedure of choice for polyposis and ulcerative colitis with medically refractory disease or dysplasia, controversy exists concerning whether mucosal preservation with double-stapled (DS) IPAA is superior to mucosectomy and handsewn (HS) IPAA anastomosis for postoperative function. Prospective studies have shown no statistically significant differences. The use of meta-analysis can strengthen statistical power by combining the data from related studies. A meta-analysis was performed to determine whether there was a significant difference in functional and manometric outcome between HS-IPAA and DS-IPAA. Prospective, randomized studies were identified using a literature search. Functional outcome variables included number of normal continence, minor incontinence, nocturnal evacuation, the ability to discriminate flatus from stool, and antidiarrheal medication. Manometric outcomes included postoperative resting and squeeze anal pressures. Four prospective, randomized trials were identified. Of the 184 total patients, the HS-IPAA group included 86 patients (48 men and 38 women) and the DS-IPAA group included 98 patients (49 men and 49 women). There were no significant differences in functional outcome between HS-IPAA and DS-IPAA. In addition, there was no significant difference in sphincter resting and squeeze pressures between the two patient groups. This meta-analysis demonstrates that DS-IPAA offers no advantage in functional or manometric outcome when compared with HS-IPAA.

Meta-analysis of observational studies of ileorectalversus ileal pouch–anal anastomosis for familial adenomatous polyposis

2006 ◽  
Vol 93 (4) ◽  
pp. 407-417 ◽  
Author(s):  
O. Aziz ◽  
T. Athanasiou ◽  
V. W. Fazio ◽  
R. J. Nicholls ◽  
A. W. Darzi ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Observational Studies ◽  
Ileal Pouch ◽  
Meta Analysis ◽  
Ileal Pouch Anal Anastomosis ◽  
Adenomatous Polyposis ◽  
Anal Anastomosis

Outcome of Ileal Pouch-anal Anastomosis in Patients With Indeterminate Colitis: A Systematic Review and Meta-analysis

2020 ◽  
Vol 14 (7) ◽  
pp. 1010-1020
Author(s):  
Sameh Hany Emile ◽  
Hayim Gilshtein ◽  
Steven D Wexner
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Ileal Pouch ◽  
Meta Analysis ◽  
Ileal Pouch Anal Anastomosis ◽  
Pelvic Sepsis ◽  
Indeterminate Colitis ◽  
Weighted Mean ◽  
Pouch Failure ◽  
Anal Anastomosis

Abstract Background Indeterminate colitis [IC] is type of inflammatory bowel disease that exhibits features of both ulcerative colitis [UC] and Crohn’s disease [CD]. The present meta-analysis aimed to assess the outcomes of ileal pouch-anal anastomosis [IPAA] in patients with IC in comparison with patients with UC. Methods A PRISMA-compliant systematic review of the outcome of IPAA in patients with IC was conducted. Electronic databases were searched, and full-text articles were reviewed to extract essential data. Main outcome measures were pouch failure and pouch-related complications. Results A total of 17 studies were included in this meta-analysis. There were 1057 patients with IC and 6511 patients with UC. The weighted mean pouch failure rate in patients with IC was 7.5 (95% confidence interval [CI]: 4.8–10.2) and the weighted mean complication rate was 67 [95% CI: 53.5–80.5]. As compared with patients with UC, patients with IC had significantly higher odds of developing complications after IPAA (odds ratio [OR]: 2.6, p <0.001): pouch fistula [OR:4.98, p <0.001], pelvic sepsis [OR:3.98, p =0.002], pelvic or cuff abscess [OR: 4.5, p <0.001], perineal complications [OR: 5.13, p <0.001], and ultimate diagnosis of CD [OR: 2.57, p <0.001]. Patients with IC and UC had similar odds of pouch failure, pouchitis, anastomotic leak, stricture, and small bowel obstruction. Conclusions Patients with IC had similar pouch failure rates, yet higher overall complication rates than patients with UC. Complications that tend to be higher after IPAA for patients with IC include pouch fistula, pelvic sepsis, abscess, perineal complications, and ultimate diagnosis of Crohn’s disease.

Benefit of antibiotic therapy on pouchitis after ileal pouch anal anastomosis: A systematic review and meta-analysis of clinical trials

Open Medicine ◽  
2009 ◽  
Vol 4 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Behzad Elahi ◽  
Shekoufeh Nikfar ◽  
Saeed Derakhshani ◽  
Mohammad Vafaie ◽  
Mohammad Abdollahi
Keyword(s):  
Clinical Trials ◽  
Odds Ratio ◽  
Ileal Pouch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Ileal Pouch Anal Anastomosis ◽  
Current Evidence ◽  
Cochrane Library ◽  
Controlled Clinical Trials ◽  
Anal Anastomosis

AbstractThe aim of the study was to evaluate and collect current evidence on the effect of antibiotics in pretreatment of pouchitis after restorative ileal pouch anal anastomosis (IPAA). Pubmed, Embase, Web of Science, Scopus, and Cochrane Library databases were searched between 1966 and July 2008; and relevant clinical trials extracted, reviewed, and validated according to the study protocol. The outcome of interest was clinical improvement after treatment. Nine randomized, placebo-controlled clinical trials were found relevant and studied but 3 of them with 70 patients were entered into meta-analysis. Pooling of the results from these trials yielded an odds ratio of 15.96 with a 95% CI of 4.20–60.70, indicating a significant OR (p<0.0001) in treatment group in comparison to the placebo group. In conclusion, the meta-analysis confirms benefit of antibiotics in management of pouchitis after IPAA operation.

Sign in / Sign up

Export Citation Format

Share Document