Study on the interaction between polyelectrolytes and oppositely charged ionic surfactants. Solubilized state of the complexes in the postprecipitation region

Catanionic vesicles are emerging interesting structures for bioapplications. They self-generate by a pairing of oppositely charged ionic surfactants that assemble into hollow structures. Specifically, the anionic-cationic surfactant pair assumes a double-tailed zwitterionic behavior. In this work, the multilamellar-to-unilamellar thermal transition of several mixed aqueous systems, with a slight excess of the anionic one, were investigated. Interestingly, it was found that the anionic counterion underwent a dissociation as a consequence of a temperature increase, leading to the mentioned thermal transition. The present work proposed the spectroscopic techniques, specifically multinuclear NMR and PGSTE (pulsed gradient stimulated echo), as a key tool to study such systems, with high accuracy and effectiveness, while requiring a small amount of the sample. The results presented herein evidence encouraging perspectives, forecasting the application of the studied vesicular nanoreservoirs, for e.g., drug delivery.

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Adsorption of ionic and non-ionic surfactants by wool charring waste

Journal of Chemical Technology & Biotechnology ◽

10.1002/jctb.280310154 ◽

1981 ◽

Vol 31 (1) ◽

pp. 395-400 ◽

Cited By ~ 7

Author(s):

Francis Perineau ◽

Antoine Gaset

Keyword(s):

Ionic Surfactants

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Artemisinin (ART) Drug Delivery Using Mixed Non-ionic Surfactants and Evaluation of Their Efficiency in Different Cancer Cell Lines

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v4i4.8861 ◽

2017 ◽

Vol 4 (4) ◽

Author(s):

Elnaz Asgharkhani ◽

Aazam Najmafshar ◽

Mohsen Chiani

Keyword(s):

Zeta Potential ◽

Cell Line ◽

Mtt Assay ◽

Therapeutic Index ◽

Stability Study ◽

Polydispersity Index ◽

Ionic Surfactants ◽

Cytotoxicity Test ◽

Molar Ratios ◽

Chemotherapy Agent

This study aims to investigate the effects of different non-ionic surfactants on physicochemical properties of ART niosomes. ART is a natural compound that is used as an antimalarial and chemotherapy agent in medicine. ART has low bioavailability, stability and solubility. In order to solve these problems and enhancing the efficiency of the drug, nanotechnology was used. In the present study, several niosomal formulations of ART prepared using different molar ratios of Span 60 : Tween 60 : PEG-600: ART in PBS. These three formulations were FI (1:1:0.5:0.5), FII (2:1:0.5:0.5) and FIII (1:2:0.5:0.5), respectively. The encapsulation efficiency was measured by HPLC and the drug release was evaluated by dialysis method. The cytotoxicity test was determined by MTT assay. The size, zeta potential and polydispersity index of the vesicles was measured by Zeta Sizer. Stability study was performed within two months. The MTT assay results showed that cytotoxicity effect of these formulations on MCF-7 cell line is better than C6 cell line and the FIII had the best results for both of them. The entrapment efficiencies of the formulations I, II and III were obtained 82.2±1.88%, 75.5±0.92% and 95.5±1.23%, respectively. The results of size, zeta potential and polydispersity index indicated that the size of the vesicles is below 200 nm, their surface charge is about -35 mV and they were monodisperse. Stability and release study indicated that the formulation III has the best stability and release pattern. Therefore, the use of PEGylated niosomal ART can effectively improve its therapeutic index, stability and solubility.

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