Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms

2002 ◽  
Vol 104 (4) ◽  
pp. 425-434 ◽  
Author(s):  
Markus Tolnay ◽  
Nicolas Sergeant ◽  
Antoine Ghestem ◽  
Sonia Chalbot ◽  
Rob A. de Vos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Protein Isoforms ◽  
Argyrophilic Grain Disease ◽  
Argyrophilic Grain ◽  
Tau Protein Isoforms

scholarly journals Argyrophilic grain disease: An underestimated tauopathy

2015 ◽  
Vol 9 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Roberta Diehl Rodriguez ◽  
Lea Tenenholz Grinberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Defense Mechanism ◽  
Neuropsychiatric Symptoms ◽  
Argyrophilic Grain Disease ◽  
Coiled Bodies ◽  
Pathologic Features ◽  
High Prevalence ◽  
Argyrophilic Grain ◽  
Argyrophilic Grains

Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer's disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer's disease. This review aims to provide an in-depth overview of the current understanding on AGD.

scholarly journals Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease

2004 ◽  
Vol 89 (1) ◽  
pp. 179-188 ◽  
Author(s):  
Chris Conrad ◽  
Cintia Vianna ◽  
Christian Schultz ◽  
Dietmar R. Thal ◽  
Estifanos Ghebremedhin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Evolution ◽  
Argyrophilic Grain Disease ◽  
Argyrophilic Grain

P3-186 Concurrent Alzheimer's disease-related pathology lowers the threshold for developing dementia in argyrophilic grain disease

2004 ◽  
Vol 25 ◽  
pp. S408-S409
Author(s):  
Dietmar R. Thal ◽  
Christian Schultz ◽  
Giovannina Botez ◽  
Mrak E. Robert ◽  
Sue T. Griffin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Argyrophilic Grain Disease ◽  
Argyrophilic Grain

scholarly journals Biochemical Analysis of τ Proteins in Argyrophilic Grain Disease, Alzheimer's Disease, and Pick's Disease

2002 ◽  
Vol 161 (4) ◽  
pp. 1135-1141 ◽  
Author(s):  
Victoria Zhukareva ◽  
Keyur Shah ◽  
Kunihiro Uryu ◽  
Heiko Braak ◽  
Kelly Del Tredici ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biochemical Analysis ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Argyrophilic Grain Disease ◽  
Argyrophilic Grain
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