Intrauterine administration of human chorionic gonadotropin improves the live birth rates of patients with repeated implantation failure in frozen-thawed blastocyst transfer cycles by increasing the percentage of peripheral regulatory T cells

2019 ◽  
Vol 299 (4) ◽  
pp. 1165-1172 ◽  
Author(s):  
Xuemei Liu ◽  
Ding Ma ◽  
Wenjuan Wang ◽  
Qinglan Qu ◽  
Ning Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Live Birth ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Blastocyst Transfer ◽  
Implantation Failure ◽  
Birth Rates ◽  
Repeated Implantation Failure ◽  
Live Birth Rates

scholarly journals Customized Frozen Embryo Transfer after Identification of the Receptivity Window with a Transcriptomic Approach Improves the Implantation and Live Birth Rates in Patients with Repeated Implantation Failure

2020 ◽  
Vol 28 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Delphine Haouzi ◽  
Frida Entezami ◽  
Antoine Torre ◽  
Charlène Innocenti ◽  
Yannick Antoine ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Hormone Replacement ◽  
Control Group ◽  
Implantation Failure ◽  
Test Results ◽  
Birth Rates ◽  
Repeated Implantation Failure ◽  
Live Birth Rates ◽  
Classical Procedure

AbstractThe aim of this prospective study was to evaluate outcome benefits expected in repeated implantation failure (RIF) patients (n = 217) after customized embryo transfer based upon identification of the receptivity window by transcriptomic approach using the Win-Test. In this test, the expression of 11 endometrial genes known to be predictive of endometrial receptivity is assessed by RT-PCR in biopsies collected during the implantation window (6–9 days after the spontaneous luteinizing hormone surge during natural cycles, 5–9 days after progesterone administration during hormone replacement therapy cycles). Then, patients underwent either customized embryo transfer (cET, n = 157 patients) according to the Win-Test results or embryo transfer according to the classical procedure (control group, n = 60). Pregnancy and live birth rates were compared in the two groups. The Win-Test showed that in 78.5% of women, the receptivity window lasted less than 48 h, although it could be shorter (< 24 h, 9.5%) or longer (> 48 h, 12%). This highlighted that only in 20% of patients with RIF the endometrium would have been receptive if the classical embryo transfer protocol was followed. In the other 80% of patients, the receptivity window was delayed by 1–3 days relative to the classical timing. This suggests that implantation failure could be linked to inadequate timing of embryo transfer. In agreement, both implantation (22.7% vs. 7.2%) and live birth rates per patient (31.8% vs. 8.3%) were significantly higher in the cET group than in the control group. cET on the basis of the Win-Test results could be proposed to improve pregnancy and live birth rates.ClinicalTrials.gov ID: NCT04192396; December 5, 2019, retrospectively registered.

scholarly journals Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenjia Bo ◽  
Ning Zhang ◽  
Ling Wang ◽  
Ying Guo ◽  
Haicui Wu
Keyword(s):  
Luteinizing Hormone ◽  
Fallopian Tube ◽  
Live Birth ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Pregnancy Outcomes ◽  
Clinical Pregnancy ◽  
Birth Rates ◽  
Live Birth Rates

Abstract Background This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility. Methods We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone ≥ 1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups. Results There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p < 0.001), number of oocytes obtained (P < 0.001) were significantly different. Conclusions Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0 and 1.25 ng/ml may lead to good clinical pregnancy outcomes.

scholarly journals Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

2020 ◽  
Author(s):  
Wenjia BO ◽  
Ning Zhang ◽  
Ling Wang ◽  
Ying Guo ◽  
Haicui Wu
Keyword(s):  
Luteinizing Hormone ◽  
Fallopian Tube ◽  
Live Birth ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Pregnancy Outcomes ◽  
Clinical Pregnancy ◽  
Birth Rates ◽  
Live Birth Rates

Abstract BACKGROUND: This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility.METHODS: We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone≥1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups.RESULTS: There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p ＜0.001), number of oocytes obtained (P＜0.001) were significantly different.CONCLUSION: Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0-1.25 ng/ml may lead to good clinical pregnancy outcomes.

Sign in / Sign up

Export Citation Format

Share Document