Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

A unilateral tumour in the nasal cavity or paranasal sinuses is commonly caused by polyps, cysts, and mucoceles, as well as invasive tumours such as papillomas and squamous cell carcinomas. Schwannomas, in contrast, are rare lesions in this area (Minhas et al., 2013). We present a case of a 52-year-old female who presented with a 4-year progressive history of mucous hypersecretion, nasal obstruction, pain, and fullness. Imaging of the paranasal sinuses showed complete opacification of the entire left nasal cavity and sinuses by a tumour causing subsequent obstruction of the frontal and maxillary sinuses. The tumour was completely excised endoscopically. Histopathology was consistent with that of a schwannoma.

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PO-491 Frequent mTORC1 activation in head and neck squamous cell carcinomas correlates with favourable clinical outcome

10.1136/esmoopen-2018-eacr25.993 ◽

2018 ◽

Author(s):

F Hermida-Prado ◽

D Garcia-Carracedo ◽

MA Villaronga ◽

S Alvarez-Teijeiro ◽

I Santamaria ◽

...

Keyword(s):

Clinical Outcome ◽

Head And Neck ◽

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Mtorc1 Activation

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ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

Cancers ◽

10.3390/cancers11121971 ◽

2019 ◽

Vol 11 (12) ◽

pp. 1971 ◽

Cited By ~ 1

Author(s):

Eva-Leonne Göttgens ◽

Corina NAM van den Heuvel ◽

Monique C de Jong ◽

Johannes HAM Kaanders ◽

William PJ Leenders ◽

...

Keyword(s):

Dna Damage ◽

Clinical Outcome ◽

Head And Neck ◽

Cell Lines ◽

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Atp Citrate Lyase ◽

Damage Repair ◽

Citrate Lyase ◽

Hnscc Cell

Radiotherapy is an important treatment modality of head and neck squamous cell carcinomas (HNSCC). Multiple links have been described between the metabolic activity of tumors and their clinical outcome. Here we test the hypothesis that metabolic features determine radiosensitivity, explaining the relationship between metabolism and clinical outcome. Radiosensitivity of 14 human HNSCC cell lines was determined using colony forming assays and the expression profile of approximately 200 metabolic and cancer-related genes was generated using targeted RNA sequencing by single molecule molecular inversion probes. Results: Correlation between radiosensitivity data and expression profiles yielded 18 genes associated with radiosensitivity or radioresistance, of which adenosine triphosphate (ATP) citrate lyase (ACLY) was of particular interest. Pharmacological inhibition of ACLY caused an impairment of DNA damage repair, specifically homologous recombination, and lead to radiosensitization in HNSCC cell lines. Examination of a The Cancer Genome Atlas (TCGA) cohort of HNSCC patients revealed that high expression of ACLY was predictive for radiotherapy failure, as it was only associated with poor overall survival in patients who received radiotherapy (hazard ratio of 2.00, 95% CI: 1.12–3.55; p = 0.0184). These data were further validated in an independent cohort of HNSCC patients treated with chemoradiation. Furthermore, patients with poor locoregional control after radiotherapy have significantly higher nuclear ACLY protein levels. Together, we here show that ACLY affects DNA damage repair, and is a predictive factor for radiotherapy outcome in HNSCC.

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