Predictive factors for simultaneous distant metastasis in head and neck cancer patients during the diagnostic work-up

2021 ◽  
Author(s):  
Carlos Miguel Chiesa-Estomba ◽  
Maria Soriano-Reixach ◽  
Ekhiñe Larruscain-Sarasola ◽  
Jon Alexander Sistiaga-Suarez ◽  
Jose Angel González-García ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Predictive Factors ◽  
Distant Metastasis ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

scholarly journals Incidental findings during the diagnostic work-up in the head and neck cancer pathway: Effects on treatment delay and survival

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 105350
Author(s):  
R.C. Schoonbeek ◽  
F.F.S. Bult ◽  
B.E.C. Plaat ◽  
M.J.H. Witjes ◽  
A. van der Hoorn ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Incidental Findings ◽  
Treatment Delay ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

P-228 Impact of Incidental Findings during Diagnostic Work-up for newly diagnosed Head and Neck Cancer patients on Delay in Treatment Initiation

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 8
Author(s):  
Rosanne C. Schoonbeek ◽  
Frederike F.S. Bult ◽  
Boudewijn E.C. Plaat ◽  
Max J.H. Witjes ◽  
Anouk van der Hoorn ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Incidental Findings ◽  
Treatment Initiation ◽  
Newly Diagnosed ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
Delay In Treatment

Re: Pre‐treatment wait time for head and neck cancer patients in Western Australia: description of a new metric and examination of predictive factors

2019 ◽  
Vol 89 (11) ◽  
pp. 1525-1526
Author(s):  
Rebecca L. Venchiarutti ◽  
Jonathan R. Clark ◽  
Carsten E. Palme ◽  
Jane M. Young
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Western Australia ◽  
Predictive Factors ◽  
Wait Time ◽  
Pre Treatment

scholarly journals EP-1170 Predictive factors of chemoradiation induced oral mucositis in head and neck cancer patients.

2019 ◽  
Vol 133 ◽  
pp. S647-S648
Author(s):  
F. Arcadipane ◽  
E. Olimpo ◽  
R. Ragona ◽  
G.C. Iorio ◽  
S. Martini ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Predictive Factors

Advances in imaging in the work-up of head and neck cancer patients

Oral Oncology ◽  
2009 ◽  
Vol 45 (11) ◽  
pp. 930-935 ◽  
Author(s):  
Remco de Bree ◽  
Jonas A. Castelijns ◽  
Otto S. Hoekstra ◽  
C. René Leemans
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Work Up

scholarly journals Clinical and histopathological risk factors for distant metastasis in head and neck cancer patients

2021 ◽  
Vol 41 (1) ◽  
pp. 6-17
Author(s):  
Carlos Miguel Chiesa-Estomba ◽  
Jerome R. Lechien ◽  
Tareck Ayad ◽  
Christian Calvo-Henriquez ◽  
José Ángel González-García ◽  
...  
Keyword(s):  
Risk Factors ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Distant Metastasis

scholarly journals miR-551a and miR-551b target GLIPR2 and promote tumor growth in High-Risk Head and Neck Cancer by modulating autophagy

2015 ◽  
Author(s):  
Narasimha Kumar Karanam ◽  
Michael D Story ◽  
◽  
◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
High Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Distant Metastasis ◽  
Mirna Expression ◽  
Migration And Invasion

Distant metastasis (DM) and local-regional recurrence (LR) after radiation and chemo therapy are major cause of treatment failure for patients with head and neck squamous cell carcinoma. However, detailed underlying mechanisms leading to DM and LR in patients are not fully understood yet. MiRNA have been proposed as biomarkers in a variety of biological and medical conditions such as cancer and stress response. The advantages of miRNA as a biomarker lies in its stability in tissues as well as body fluids, hence the potential for non-invasive diagnosis and prognosis. In this study, towards understanding the molecular mechanism causing DM and LR in HN cancer patients we performed miRNA expression profiling using tumor samples from 118 head and neck cancer patients treated by post-operative radiotherapy (PORT) at M.D. Anderson Cancer Center from 1992 to 1999. All patients were considered to be at high-risk for recurrence having histologically proven advanced squamous cell carcinoma. Amongst these samples, 41 found to have distant metastasis (DM), 53 responded without relapse (no evidence of disease (NED)) to PORT. Comparison of miRNA expression between DM and NED specimens using two-way ANOVA identified 28 miRNAs that were differentially expressed with statistical significance (FDR < 0.2 and fold change > 1.5). Amongst these 28 miRNAs seen in the DM and NED outcome groups, miRNAs 551a and 551b are significantly associated with the DM group. Interestingly these two miRNAs share same seed sequence. Moreover Kaplan-Meir survival analysis in our data set and two other data sets suggested that miR-551a and miR-551b expressions are associated with poor survival in patients. We further performed cell proliferation, migration and invasion assays using the HN5 and UMSCC- 17B head and neck cancer cell lines by transfection of either mimic or an inhibitor of miR-551a and miR-551b. The results suggested that miR-551a and miR-551b mimics promote proliferation, migration and invasion whereas the inhibitor decreased. Further studies indicated that these miRNAs target GLIPR2 expression and miR-551a, miR-551b and GLIPR2 axis at least in part plays an important role in tumor progression. Hence we need to further explore miR-551a and miR-551b-3p role in HN cancer progression in detail in in-vivo models to use them as therapeutic targets in future.

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