Detection of intrathrombotic endothelial progenitor cells and its application to thrombus age estimation in a murine deep vein thrombosis model

2017 ◽  
Vol 131 (6) ◽  
pp. 1633-1638 ◽  
Author(s):  
Mizuho Nosaka ◽  
Yuko Ishida ◽  
Akihiko Kimura ◽  
Hiroki Yamamoto ◽  
Takashi Kato ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Age Estimation ◽  
Endothelial Progenitor ◽  
Vein Thrombosis ◽  
Thrombosis Model ◽  
Deep Vein

Immunohistochemical detection of intrathrombotic fibrocytes and its application to thrombus age estimation in murine deep vein thrombosis model

2016 ◽  
Vol 131 (1) ◽  
pp. 179-183 ◽  
Author(s):  
Mizuho Nosaka ◽  
Yuko Ishida ◽  
Akihiko Kimura ◽  
Takashi Kawaguchi ◽  
Hiroki Yamamoto ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Age Estimation ◽  
Immunohistochemical Detection ◽  
Vein Thrombosis ◽  
Thrombosis Model ◽  
Deep Vein

miRNA-130 Promotes Migration and Angiogenesis of Endothelial Progenitor Cells Through PI3K/AKT/mTOR Pathways

2022 ◽  
Vol 12 (1) ◽  
pp. 206-214
Author(s):  
Ru-Sheng Liu ◽  
Bin Li ◽  
Wen-Dong Li ◽  
Xiao-Long Du ◽  
Xiao-Qiang Li
Keyword(s):  
Progenitor Cells ◽  
Signaling Pathway ◽  
Endothelial Progenitor Cells ◽  
Tube Formation ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Endothelial Progenitor ◽  
Vein Thrombosis ◽  
Deep Vein

<sec> <title>Aim:</title> In this study, we aimed to investigate the effects and mechanisms of miRNA-130a in human endothelial progenitor cells (EPCs) involved in Deep vein thrombosis (DVT). </sec> <sec> <title>Methods:</title> EPCs were isolated and identified by cell morphology and surface marker detection. The effect of miR-130a on the migration, invasion and angiogenesis of EPCs in vitro were also detected. In addition, whether miR-130a is involved in the MMP-1 expression and Akt/PI3K/mTOR signaling pathway was also demonstrated. </sec> <sec> <title>Results:</title> Results suggested that miRNA-130a promotes migration, invasion, and tube formation of EPCs by positively regulating the expression of MMP-1 through Akt/PI3K/mTOR signaling pathway. </sec> <sec> <title>Conclusion:</title> Thus, as a potential therapeutic target, miRNA-130a may play an important role in the treatment of DVT. </sec>

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