Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

2015 ◽  
Vol 262 (11) ◽  
pp. 2491-2497 ◽  
Author(s):  
E. J. Lampert ◽  
M. Andorra ◽  
R. Torres-Torres ◽  
S. Ortiz-Pérez ◽  
S. Llufriu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Ganglion Cell ◽  
Color Vision ◽  
Retinal Ganglion Cell ◽  
Cell Damage ◽  
Vision Impairment ◽  
Retinal Ganglion ◽  
Color Vision Impairment

Longitudinal Study of Retinal Ganglion Cell Layer Thickness by OCT in Multiple Sclerosis (S48.003)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S48.003-S48.003
Author(s):  
E. Davies ◽  
H. Ishikawa ◽  
K. Galetta ◽  
R. Sakai ◽  
D. Feller ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Longitudinal Study ◽  
Ganglion Cell ◽  
Layer Thickness ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Layer

Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis

2006 ◽  
Vol 12 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Kenneth S Shindler ◽  
Yangtai Guan ◽  
Elvira Ventura ◽  
Jean Bennett ◽  
Abdolmohamad Rostami
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Neuronal Loss ◽  
Proteolipid Protein ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Acute Optic Neuritis ◽  
Demyelinating Lesions

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are marked by inflammatory demyelinating lesions throughout the central nervous system, including optic nerve. Neuronal loss also occurs in MS and EAE lesions, but it is not known whether neuronal loss occurs secondary to inflammation, or as a primary process. In the current study, the relationship of inflammation to retinal ganglion cell (RGC) loss during acute optic neuritis is examined. RGCs were labelled with Flourogold, and EAE was induced in SJL/J mice by immunization with proteolipid protein peptide 139- 151 (PLP). At various time points, RGCs were counted and optic nerves were examined for inflammatory cell infiltrates. No optic neuritis was detected prior to day 9 following immunization. Incidence of optic neuritis was 30% at day 9 and increased to over 70% by day 11, remaining high through day 18. In contrast, no RGC loss was detected in eyes with optic neuritis until day 14. A 43.1% reduction in RGC numbers at day 14 increased to 50.8% by day 18. No RGC loss occurred in eyes without optic neuritis. The fact that inflammation precedes RGC loss suggests that neuronal loss during optic neuritis occurs secondary to the inflammatory process.

scholarly journals Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage

2003 ◽  
Vol 43 (5) ◽  
pp. 497-503 ◽  
Author(s):  
Robert Rejdak ◽  
Tomasz Zarnowski ◽  
Waldemar A. Turski ◽  
Tomasz Kocki ◽  
Zbigniew Zagorski ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Acid Content ◽  
Kynurenic Acid ◽  
Cell Damage ◽  
Retinal Ganglion

Frequent retinal ganglion cell damage after acute optic neuritis

2018 ◽  
Vol 22 ◽  
pp. 141-147 ◽  
Author(s):  
Alexander U. Brandt ◽  
Svenja Specovius ◽  
Timm Oberwahrenbrock ◽  
Hanna G. Zimmermann ◽  
Friedemann Paul ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Damage ◽  
Retinal Ganglion ◽  
Acute Optic Neuritis

scholarly journals Toxicity testing of the VEGF inhibitors bevacizumab, ranibizumab and pegaptanib in rats both with and without prior retinal ganglion cell damage

2008 ◽  
Vol 88 (5) ◽  
pp. e170-e176 ◽  
Author(s):  
Sebastian Thaler ◽  
Michal Fiedorowicz ◽  
Tomasz J. Choragiewicz ◽  
Sylvia Bolz ◽  
Ayseguel Tura ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Damage ◽  
Toxicity Testing ◽  
Retinal Ganglion ◽  
Vegf Inhibitors
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