scholarly journals Epileptic seizures in multiple sclerosis: prevalence, competing causes and diagnostic accuracy

2020 ◽  
Author(s):  
Friederike Neuß ◽  
Felix von Podewils ◽  
Zhong Irene Wang ◽  
Marie Süße ◽  
Uwe Klaus Zettl ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Traumatic Brain Injury ◽  
Cerebral Ischemia ◽  
Epileptic Seizures ◽  
Population Based ◽  
Patient History ◽  
Population Based Study ◽  
Total Prevalence ◽  
Increased Risk ◽  
Competing Causes

Abstract Background Multiple sclerosis (MS) is accompanied by an increased risk of epileptic seizures, but data with a detailed description of the competing causes are lacking. Methods We aimed to describe a cohort of patients with both MS and epileptic seizures in a retrospective, population-based study. Results We included 59 out of 2285 MS patients who had at least one epileptic seizure. Out of them, 22 had seizures before the diagnosis of MS, whereas epileptic seizures occurred after MS diagnosis in 37 patients, resulting in a total prevalence of epileptic seizures in MS of 2.6%. Competing causes could be found in 50.8% (30/59) of all patients, with 40.9% (9/22) compared to 56.8% (21/37) of the MS patients with seizures before vs after MS diagnosis. The main alternative causes were traumatic brain injury and cerebral ischemia accounting for more than 30% of the patients, with no difference between the subgroups. 33.3% and 55.6% of MS patients with seizures before/after MS diagnosis had documented pathological EEG alterations. Conclusion A remarkable percentage of MS patients with epileptic seizures do have alternative competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG and MRI is recommended in the evaluation and choice for the best treatment.

Conjugal multiple sclerosis in Isfahan, Iran: a population-based study

2007 ◽  
Vol 13 (5) ◽  
pp. 673-675 ◽  
Author(s):  
A.H. Maghzi ◽  
M. Etemadifar ◽  
V. Shaygannejad ◽  
M. Saadatnia ◽  
M. Salehi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
General Population ◽  
Environmental Factors ◽  
Adult Life ◽  
Marital Relationship ◽  
Population Based ◽  
Rare Form ◽  
Population Based Study ◽  
Increased Risk ◽  
Estimated Risk

Conjugal multiple sclerosis (MS) is a rare form of MS in which both spouses are affected, and at least one is affected after marriage. Among 1606 definite MS patients, 1076 were in marital relationship, among whom we identified six conjugal pairs, giving the conjugal rate of 0.5%. This rate is 12.5 times higher than the estimated risk of MS for the general population (0.04%). The observed conjugal rate suggests an increased risk of developing MS for MS patients' spouses, this could be due to transmission or, more likely, to the same environmental factors shared in adult life. Multiple Sclerosis 2007; 13: 673-675. http://msj.sagepub.com

scholarly journals Increased Risk of Multiple Sclerosis Following Herpes Zoster: A Nationwide, Population-Based Study

2011 ◽  
Vol 204 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Jiunn-Horng Kang ◽  
Jau-Jiuan Sheu ◽  
Senyeong Kao ◽  
Herng-Ching Lin
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Zoster ◽  
Population Based ◽  
Population Based Study ◽  
Increased Risk

Population based study on patients with traumatic brain injury suggests increased risk of dementia

2012 ◽  
Vol 83 (11) ◽  
pp. 1080-1085 ◽  
Author(s):  
Hao-Kuang Wang ◽  
Sheng-Hsiang Lin ◽  
Pi-Shan Sung ◽  
Ming-Hsiu Wu ◽  
Kuo-Wei Hung ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Population Based ◽  
Population Based Study ◽  
Increased Risk

Have patients with oesophagitis got an increased risk of adenocarcinoma? Results from a population-based study

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
SJ Murphy ◽  
LA Anderson ◽  
BT Johnston ◽  
DA Fitzpatrick ◽  
RGP Watson ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Increased Risk

scholarly journals Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Hossein Farhadnejad ◽  
Karim Parastouei ◽  
Hosein Rostami ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi
Keyword(s):  
Metabolic Syndrome ◽  
Positive Association ◽  
Population Based ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
Confounding Variables ◽  
Adjusted Model ◽  
Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

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