scholarly journals Correction to: Bone mineral density in high-level endurance runners: part A—site-specific characteristics

2021 ◽  
Author(s):  
A. J. Herbert ◽  
A. G. Williams ◽  
S. J. Lockey ◽  
R. M. Erskine ◽  
C. Sale ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Site Specific ◽  
Endurance Runners ◽  
High Level ◽  
A Site

scholarly journals Bone mineral density in high-level endurance runners: part A—site-specific characteristics

2021 ◽  
Author(s):  
A. J. Herbert ◽  
A. G. Williams ◽  
S. J. Lockey ◽  
R. M. Erskine ◽  
C. Sale ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Mechanical Loading ◽  
Bone Mineral ◽  
Small Sample ◽  
Energy Availability ◽  
Mineral Density ◽  
Site Specific ◽  
Endurance Runners ◽  
High Level

Abstract Purpose Physical activity, particularly mechanical loading that results in high-peak force and is multi-directional in nature, increases bone mineral density (BMD). In athletes such as endurance runners, this association is more complex due to other factors such as low energy availability and menstrual dysfunction. Moreover, many studies of athletes have used small sample sizes and/or athletes of varying abilities, making it difficult to compare BMD phenotypes between studies. Method The primary aim of this study was to compare dual-energy X-ray absorptiometry (DXA) derived bone phenotypes of high-level endurance runners (58 women and 45 men) to non-athletes (60 women and 52 men). Our secondary aim was to examine the influence of menstrual irregularities and sporting activity completed during childhood on these bone phenotypes. Results Female runners had higher leg (4%) but not total body or lumbar spine BMD than female non-athletes. Male runners had lower lumbar spine (9%) but similar total and leg BMD compared to male non-athletes, suggesting that high levels of site-specific mechanical loading was advantageous for BMD in females only and a potential presence of reduced energy availability in males. Menstrual status in females and the number of sports completed in childhood in males and females had no influence on bone phenotypes within the runners. Conclusion Given the large variability in BMD in runners and non-athletes, other factors such as variation in genetic make-up alongside mechanical loading probably influence BMD across the adult lifespan.

scholarly journals Bone mineral density in high-level endurance runners: Part B—genotype-dependent characteristics

2021 ◽  
Author(s):  
A. J. Herbert ◽  
A. G. Williams ◽  
S. J. Lockey ◽  
R. M. Erskine ◽  
C. Sale ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Mechanical Loading ◽  
Bone Mineral ◽  
Genetic Interaction ◽  
Association Studies ◽  
Individual Variability ◽  
Mineral Density ◽  
Lower Lumbar Spine ◽  
Endurance Runners ◽  
High Level

Abstract Purpose Inter-individual variability in bone mineral density (BMD) exists within and between endurance runners and non-athletes, probably in part due to differing genetic profiles. Certainty is lacking, however, regarding which genetic variants may contribute to BMD in endurance runners and if specific genotypes are sensitive to environmental factors, such as mechanical loading via training. Method Ten single-nucleotide polymorphisms (SNPs) were identified from previous genome-wide and/or candidate gene association studies that have a functional effect on bone physiology. The aims of this study were to investigate (1) associations between genotype at those 10 SNPs and bone phenotypes in high-level endurance runners, and (2) interactions between genotype and athlete status on bone phenotypes. Results Female runners with P2RX7 rs3751143 AA genotype had 4% higher total-body BMD and 5% higher leg BMD than AC + CC genotypes. Male runners with WNT16 rs3801387 AA genotype had 14% lower lumbar spine BMD than AA genotype non-athletes, whilst AG + GG genotype runners also had 5% higher leg BMD than AG + GG genotype non-athletes. Conclusion We report novel associations between P2RX7 rs3751143 genotype and BMD in female runners, whilst differences in BMD between male runners and non-athletes with the same WNT16 rs3801387 genotype existed, highlighting a potential genetic interaction with factors common in endurance runners, such as high levels of mechanical loading. These findings contribute to our knowledge of the genetic associations with BMD and improve our understanding of why some runners have lower BMD than others.

Site-specific effects of trunk fat mass on bone mineral density in a group of adolescent girls

2012 ◽  
Vol 27 (3) ◽  
pp. 175-179
Author(s):  
R. El Hage ◽  
C. Jacob ◽  
E. Moussa ◽  
R. Baddoura
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Adolescent Girls ◽  
Fat Mass ◽  
Mineral Density ◽  
Site Specific ◽  
Specific Effects

scholarly journals Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs

2017 ◽  
Vol 8 ◽  
Author(s):  
Matthias C. Schulz ◽  
Jan Kowald ◽  
Sven Estenfelder ◽  
Roland Jung ◽  
Eberhard Kuhlisch ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Site Specific

Site-specific differences in bone mineral density in black and white premenopausal South African women

2011 ◽  
Vol 23 (2) ◽  
pp. 533-542 ◽  
Author(s):  
S. Chantler ◽  
K. Dickie ◽  
J. H. Goedecke ◽  
N. S. Levitt ◽  
E. V. Lambert ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
South African ◽  
Bone Mineral ◽  
African Women ◽  
Mineral Density ◽  
Site Specific ◽  
Black And White ◽  
South African Women

Low lumbar spine bone mineral density in both male and female endurance runners

Bone ◽  
2006 ◽  
Vol 39 (4) ◽  
pp. 880-885 ◽  
Author(s):  
K. Hind ◽  
J.G. Truscott ◽  
J.A. Evans
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Male And Female ◽  
Endurance Runners
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