The role of endocytosis in renal dopamine D1 receptor signaling

2005 ◽  
Vol 451 (6) ◽  
pp. 793-802 ◽  
Author(s):  
Hjalmar Brismar ◽  
Xiang Hua ◽  
Shinsuke Adachi ◽  
Ulla Holtbäck
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Signaling ◽  
Renal Dopamine

scholarly journals Diminished Role of Dopamine D1-Receptor Signaling with the Development of an Addicted Phenotype in Rats

2014 ◽  
Vol 76 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Carolina P. Ramôa ◽  
Susan E. Doyle ◽  
Matthew D. Lycas ◽  
Andrea K. Chernau ◽  
Wendy J. Lynch
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Signaling

Abstract P337: Angiotensin 1-7 Mitigates Oxidative Stress, Protects Renal Dopamine D1 Receptor Function and Prevents Development of Hypertension

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Mustafa Lokhandwala ◽  
Andrea Diaz Diaz ◽  
Anees Ahamd Banday
Keyword(s):  
Oxidative Stress ◽  
Buthionine Sulfoximine ◽  
Chronic Administration ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Sodium Reabsorption ◽  
Sodium Regulation ◽  
Renal Dopamine ◽  
Renal Sodium Reabsorption

The role of angiotensin in etiology of cardiovascular diseases especially in hypertension is well established. Renin-angiotensin-aldosterone contributes to the development and maintenance of hypertension directly by increases in vascular tone and renal sodium reabsorption or indirectly by increasing oxidative stress and inflammation. Contrary to this pathological arm, angiotensin (Ang) 1-7 via Mas receptors has been reported to protect the cardiovascular function although the exact mechanism is not yet clear. We have previously shown that oxidative stress leads to renal dopamine D1 receptor (D1R) dysfunction which could disrupt sodium regulation and subsequently lead to hypertension. In here we wanted to test whether chronic administration of Ang 1-7 in mice could mitigate oxidative stress, protect renal D1R function and prevent development of hypertension. Mice (C57BL) were implanted with telemetry probes and concomitantly treated with L-buthionine sulfoximine (BSO, in drinking water) and Ang 1-7 (via jugular vein by osmotic pumps). Control (C, no treatment) and shams (implanted with saline filled pumps) exhibited similar behavioral and physiological parameters. Mice treated with BSO alone exhibited increased oxidative stress and high BP as compared to controls. Ang 1-7 treatment did not affect oxidative stress and BP in control mice but prevented the increase in BP and oxidative milieu in BSO treated mice. Mean arterial pressure (mmHg), C: 78.5 ± 2.3*; BSO: 97.3 ± 3.8; Ang 1-7: 80.1* ± 4.1; BSO+Ang 1-7: 83.2 ± 3.4*, *P <0.05 vs BSO. SKF38393, a D1R agonist, increased urine and sodium excretion in control mice but failed to induce diuresis or natriuresis in BSO-treated mice. Treatment with Ang 1-7 protected D1R function as both natriuresis and diuresis was observed in mice treated with BSO plus Ang 1-7. Chronic Ang 1-7 had no effect on D1R function in the absence of BSO. These data show that oxidative stress leads to hypertension by disrupting renal D1R dependent sodium regulation. Ang 1-7 mitigates oxidative stress, protects renal D1R function and prevents increase in BP. This study provides a new insight on how beneficial arm of Ang system could protect renal D1R-mediated sodium regulation and prevent development of hypertension during oxidative stress.

scholarly journals Glycaemic control with insulin prevents the reduced renal dopamine D1 receptor expression and function in streptozotocin-induced diabetes

2010 ◽  
Vol 25 (9) ◽  
pp. 2945-2953 ◽  
Author(s):  
M. Moreira-Rodrigues ◽  
J. Quelhas-Santos ◽  
P. Serrao ◽  
C. Fernandes-Cerqueira ◽  
B. Sampaio-Maia ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Expression ◽  
Streptozotocin Induced Diabetes ◽  
Renal Dopamine ◽  
And Function

5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

2019 ◽  
Vol 121 ◽  
pp. 120-130 ◽  
Author(s):  
Silvia Fanni ◽  
Simona Scheggi ◽  
Francesca Rossi ◽  
Elisabetta Tronci ◽  
Francesco Traccis ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Interaction ◽  
Receptor Signaling ◽  
D3 Receptor ◽  
Reductase Inhibitors ◽  
Receptor Signaling Pathway

Effects of long-term ouabain treatment on blood pressure, sodium excretion, and renal dopamine D1 receptor levels in rats

2009 ◽  
Vol 180 (1) ◽  
pp. 117-124 ◽  
Author(s):  
Yurong Zhang ◽  
Zuyi Yuan ◽  
Heng Ge ◽  
Yanping Ren
Keyword(s):  
Blood Pressure ◽  
Sodium Excretion ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Renal Dopamine

Defective Renal Dopamine D1 Receptor Function Contributes to Hyperinsulinemia-Mediated Hypertension

2006 ◽  
Vol 28 (8) ◽  
pp. 695-705 ◽  
Author(s):  
Anees Ahmad Banday ◽  
Mustafa F. Lokhandwala
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Function ◽  
Renal Dopamine

ENHANCEMENT OF COGNITION IN SCHIZOPHRENIA VIA INHIBITION OF PHOSPHODIESTERASE-1B AND POTENTIATION OF DOPAMINE D1 RECEPTOR SIGNALING

2010 ◽  
Vol 117 (2-3) ◽  
pp. 489 ◽  
Author(s):  
Lawrence Wennogle ◽  
Gretchen Snyder ◽  
Peng Li ◽  
Kimberly Vanover ◽  
Robert Davis ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Signaling

Role of Ventral Striatal Dopamine D1 Receptor in Cigarette Craving

2007 ◽  
Vol 61 (11) ◽  
pp. 1252-1259 ◽  
Author(s):  
Fumihiko Yasuno ◽  
Miho Ota ◽  
Kiyoshi Ando ◽  
Tomomichi Ando ◽  
Jun Maeda ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Striatal Dopamine ◽  
Cigarette Craving

P.6.034 Role of dopamine D1 receptor on dopaminergic supersensitivity induced by sleep deprivation in mice

2004 ◽  
Vol 14 ◽  
pp. S371
Author(s):  
C.C. Chinen ◽  
R.R. Faria ◽  
R. Frussa Filho
Keyword(s):  
Sleep Deprivation ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Dopaminergic Supersensitivity
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