The reduced myofilament responsiveness to calcium contributes to the negative force-frequency relationship in rat cardiomyocytes: role of reactive oxygen species and p-38 map kinase

2017 ◽  
Vol 469 (12) ◽  
pp. 1663-1673 ◽  
Author(s):  
María Sofía Espejo ◽  
Ignacio Aiello ◽  
Marisa Sepúlveda ◽  
Martín G. Vila Petroff ◽  
Ernesto A. Aiello ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Map Kinase ◽  
Reactive Oxygen ◽  
Force Frequency ◽  
Oxygen Species ◽  
Rat Cardiomyocytes ◽  
Frequency Relationship

scholarly journals Effects of Organochlorine Insecticides on MAP Kinase Pathways in Human HaCaT Keratinocytes: Key Role of Reactive Oxygen Species

2005 ◽  
Vol 86 (2) ◽  
pp. 444-452 ◽  
Author(s):  
Nathalie Ledirac ◽  
Sebastien Antherieu ◽  
Anne Dupuy d'Uby ◽  
Jean-Claude Caron ◽  
Roger Rahmani
Keyword(s):  
Reactive Oxygen Species ◽  
Map Kinase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Hacat Keratinocytes ◽  
Organochlorine Insecticides ◽  
Map Kinase Pathways

The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis

2020 ◽  
Vol 21 (5) ◽  
pp. 477-498
Author(s):  
Yongfeng Chen ◽  
Xingjing Luo ◽  
Zhenyou Zou ◽  
Yong Liang
Keyword(s):  
Reactive Oxygen Species ◽  
Bone Marrow ◽  
Oxidative Damage ◽  
Tumor Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
Normal Cells ◽  
Treatment And Prevention

Reactive oxygen species (ROS), an important molecule inducing oxidative stress in organisms, play a key role in tumorigenesis, tumor progression and recurrence. Recent findings on ROS have shown that ROS can be used to treat cancer as they accelerate the death of tumor cells. At present, pro-oxidant drugs that are intended to increase ROS levels of the tumor cells have been widely used in the clinic. However, ROS are a double-edged sword in the treatment of tumors. High levels of ROS induce not only the death of tumor cells but also oxidative damage to normal cells, especially bone marrow hemopoietic cells, which leads to bone marrow suppression and (or) other side effects, weak efficacy of tumor treatment and even threatening patients’ life. How to enhance the killing effect of ROS on tumor cells while avoiding oxidative damage to the normal cells has become an urgent issue. This study is a review of the latest progress in the role of ROS-mediated programmed death in tumor treatment and prevention and treatment of oxidative damage in bone marrow induced by ROS.

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